[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-367428-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-367428-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","epigenetic-regulation-of-ferroptosis-in-gastrointestinal-cancers-review-review","Epigenetic regulation of ferroptosisin gastrointestinal cancers (Review) - Review","","Ferroptosis is an iron-dependent form of regulated cell death marked by excessive lipid peroxidation. Research increasingly shows that epigenetic modifications strongly shape how cancer cells respond to ferroptosis, influencing the sensitivity of gastrointestinal cancers and thereby cell fate. Epigenetic mechanisms including DNA methylation, histone modifications and non-coding RNAs regulate ferroptosis-related gene expression, producing either sensitizing or inhibitory effects. The review summarizes drug strategies targeting epigenetic markers to trigger ferroptosis and reduce tumor growth, while linking epigenetic control to therapeutic opportunities.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/epigenetic-regulation-of-ferroptosis-in-gastrointestinal-cancers-review-review/367428/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/epigenetic-regulation-of-ferroptosis-in-gastrointestinal-cancers-review-review/367428.png","ImageObject",300,407,{"name":42,"@type":43},"Sophia Brooks","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is ferroptosis and why is it relevant to cancer?","Question",{"text":63,"@type":64},"Ferroptosis is an iron-dependent regulated cell death characterized by excessive lipid peroxidation and iron accumulation. It is relevant because triggering ferroptosis may help combat tumors, including overcoming therapeutic resistance.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do epigenetic modifications influence ferroptosis in gastrointestinal cancers?",{"text":68,"@type":64},"Epigenetic processes such as DNA methylation, histone modifications, and non-coding RNAs regulate the expression of ferroptosis-related genes. These changes can either enhance or inhibit the sensitivity of gastrointestinal cancer cells to ferroptosis.",{"name":70,"@type":61,"acceptedAnswer":71},"What therapeutic strategies does the review discuss regarding epigenetics and ferroptosis?",{"text":72,"@type":64},"The review explores leveraging epigenetic modifications to trigger ferroptosis in gastrointestinal cancers. It also highlights drugs targeting epigenetic markers as promising approaches for advanced-stage cancer by enhancing ferroptosis and inhibiting tumor growth.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},367428,1790197511,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":118,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":104},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 55: 93, 2025  \nEpigenetic regulation of ferroptosisin gastrointestinal cancers (Review)  \nLINQIANG GONG 1* , LINLIN WU2* , SHIYUAN ZHAO3,4 , SHUAI XIAO5 , XUE CHU3 , YAZHOU ZHANG6 , FENGFENG LI7 , SHUHUI LI 1 , HUI YANG8 and PEI JIANG3,4  \n1Department of Gastroenterology, Tengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China; 2Oncology Department,  \n3  \nTengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China; 4Institute of Translational Pharmacy,  \n5  \nJining Medical Research Academy, Jining, Shandong 272000, P.R. China; Department of Intensive Care Medicine, Tengzhou Central People's Hospital, Jining Medical University, Tengzhou, Shandong 277500, P.R. China; 6Department of Foot and Ankle Surgery, Tengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China;  \n7Neurosurgery Department, Tengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China;  \n8Department of Gynecology, Tengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China  \nReceived November 13, 2024; Accepted April 3, 2025  \nDOI: 10.3892/ijmm.2025.5534  \nAbstract. Ferroptosis is a type of iron‑dependent cell death characterized by excessive lipid peroxidation and may serve as a potential therapeutic target in cancer treatment. While the mechanisms governing ferroptosis continue to be explored and elucidated, an increasing body of research highlights the significant impact of epigenetic modifications on the sensi‑ tivity of cancer cells to ferroptosis. Epigenetic processes, such as DNA methylation, histone modifications and non‑coding RNAs, have been identified as key regulators that modulate the expression of ferroptosis‑related genes. These alterationscan either enhance or inhibit the sensitivity of gastrointestinal cancer (GIC) cells to ferroptosis, thereby affecting the fate of GICs. Drugs that target epigenetic markers for advanced‑stage cancer have shown promising results in enhancing ferroptosisand inhibiting tumor growth. This review explores the intri‑ cate relationship between epigenetic regulation and ferroptosisin GICs. Additionally, the potential of leveraging epigenetic modifications to trigger ferroptosis in GICs is investigated.  \nCorrespondence to: Professor Hui Yang, Department of Gynecology, Tengzhou Central People's Hospital, 181 Xingtan Road, Tengzhou, Shandong 277500, P.R. China  \nE‑mail: jiayu‑[1987@163.com](1987@163.com)  \nProfessor Pei Jiang, Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, 6 Jiankang Road, Jining, Shandong 272000, P.R. China  \nE‑mail: [jiangpeicsu@sina.com](jiangpeicsu@sina.com)  \n*Contributed equally  \nKey words: epigenetic, ferroptosis, gastrointestinal cancers, regulation  \nThis review highlights the importance of further research to elucidate the specific mechanisms underlying epigenetic control of ferroptosis and to advance the development of novel therapeutic approaches.  \nContents  \n1. Introduction  \n2. Ferroptosis: Mechanisms and implications  \n3. Epigenetic regulation of ferroptosis in GICs  \n4. Clinical applications  \n5. Conclusions and future perspectives  \n1. Introduction  \nGastrointestinal cancers (GICs) account for >25% of all new cancer cases worldwide and contribute to more than one‑third of cancer‑related deaths (1) . These cancers primarily include gastric cancer (GC), colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), gallbladder cancer (GBC) and pancreatic cancer. Traditional treatments for GICs, including surgery intervention, radiation therapy, chemo‑ therapy, targeted therapies and immunotherapies, have long been the primary approaches for management (2,3) . However, early diagnosis of GICs is challenging a","cbCaiaUtSVGtSF6v","https://ap.wps.com/l/cbCaiaUtSVGtSF6v","pdf",3309736,"English","# Introduction\n# Ferroptosis: Mechanisms and implications\n# Epigenetic regulation of ferroptosis in GICs\n# Clinical applications\n# Conclusions and future perspectives","[{\"question\":\"What is ferroptosis and why is it relevant to cancer?\",\"answer\":\"Ferroptosis is an iron-dependent regulated cell death characterized by excessive lipid peroxidation and iron accumulation. It is relevant because triggering ferroptosis may help combat tumors, including overcoming therapeutic resistance.\"},{\"question\":\"How do epigenetic modifications influence ferroptosis in gastrointestinal cancers?\",\"answer\":\"Epigenetic processes such as DNA methylation, histone modifications, and non-coding RNAs regulate the expression of ferroptosis-related genes. These changes can either enhance or inhibit the sensitivity of gastrointestinal cancer cells to ferroptosis.\"},{\"question\":\"What therapeutic strategies does the review discuss regarding epigenetics and ferroptosis?\",\"answer\":\"The review explores leveraging epigenetic modifications to trigger ferroptosis in gastrointestinal cancers. It also highlights drugs targeting epigenetic markers as promising approaches for advanced-stage cancer by enhancing ferroptosis and inhibiting tumor growth.\"}]","Epigenetic regulation of ferroptosisin gastrointestinal cancers (Review) - Review | PDF",1790170757]