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Understanding tumorigenesis is essential for early prevention and treatment. Epigenetic modification—including DNA methylation, histone changes, non-coding RNA alterations, and m6A—regulates key proteins that govern programmed cell death. Beyond apoptosis, distinct modalities such as pyroptosis, ferroptosis, cuproptosis, and disulfidptosis have emerged. The review examines how epigenetic mechanisms control these deaths in tumor cells, identifies possible triggering factors, and highlights targets for tumor therapy and future antitumor drug development or combination regimens.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/epigenetic-regulation-of-diverse-cell-death-modalities-in-cancer-a-focus-on-pyroptosis-ferroptosis-cuproptosis-and-disulfidptosis/330474/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/epigenetic-regulation-of-diverse-cell-death-modalities-in-cancer-a-focus-on-pyroptosis-ferroptosis-cuproptosis-and-disulfidptosis/330474.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the role of epigenetic modifications in regulating cancer cell death?","Question",{"text":112,"@type":113},"Epigenetic regulation affects cancer cell death mainly by upregulating or downregulating key cell death proteins, thereby influencing the expression levels of critical regulators.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cell death modalities are emphasized beyond classic programmed death?",{"text":117,"@type":113},"The document focuses on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis, describing them as newly recognized modes with increasing attention for their effects on tumor progression.",{"name":119,"@type":110,"acceptedAnswer":120},"What main mechanisms are linked to ferroptosis and cuproptosis?",{"text":121,"@type":113},"Ferroptosis and cuproptosis are attributed to disrupted metal homeostasis, Fe2+ and Cu+ imbalance, which alters signaling pathways relevant to cancer development.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330474,1790790012,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Zhou et al. Journal of Hematology & Oncology (2024) 17:22 [https://doi.org/10.1186/s13045-024-01545-6](https://doi.org/10.1186/s13045-024-01545-6)  \nJournal of Hematology & Oncology  \nREVIEW Open Access  \nEpigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis  \nShimeng Zhou 1,2†, Junlan Liu 1,2†, Andi Wan 1,2, Yi Zhang 1,2* and Xiaowei Qi 1,2*  \nAbstract  \nTumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by upregulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies. Keywords Epigenetic modification, Pyroptosis, Ferroptosis, Cuproptosis, Disulfidptosis  \nIntroduction  \nCancer, the leading cause of global human death, refers to the proliferation of local histiocytes caused by some tumorigenic factors. The whole process is generally divided into four stages: precancerous lesion, carcinoma in situ, invasive carcinoma and metastasis [1, 2]. Cancer represents a complex ecosystem, including cancer cells  \n†Shimeng Zhou and Junlan Liu contributed equally to this work.  \n*Correspondence: Yi Zhang [ZY53810@163.com](ZY53810@163.com)[ ](ZY53810@163.com)Xiaowei Qi [qxw9908@foxmail.com](qxw9908@foxmail.com)  \n1Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China  \n2Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China  \nand non-cancer cells. Various cell-cell interactions form the tumor microenvironment (TME), which includes immune cells, cancer-associated fibroblasts, and endothelial cells [2]. TME is involved in biological functions of cancer, such as maintaining proliferation, inducing angiogenesis, activating invasion and metastasis, and promoting inflammation [3]. Non-physiological death of cancer cells affects tumor progression.  \nCell death has physiological and pathological functions. However, infection, chronic inflammation and tissue damage lead to sudden death of a large number of cells and then the release of large amount of cellular content into the extracellular space causes damage to the organ [4]. Cell death can be induced by genetically programmed suicide mechanisms such as apoptosis, necrotic apoptosis and pyroptosis, or it can be attributed to metabolic dysregulation, such as ferroptosis,  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If mate","cbCaieRC19VBPkkn","https://ap.wps.com/l/cbCaieRC19VBPkkn","pdf",5201524,"English","# Introduction\n## Epigenetic modification and programmed cell death\n## New cell death modalities in cancer\n# Tumor microenvironment and death-related mechanisms\n## Roles of inflammation and damage in cell death\n## Balance between cell death and proliferation\n# Focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis\n## Mechanistic characteristics of each modality","[{\"question\":\"What is the role of epigenetic modifications in regulating cancer cell death?\",\"answer\":\"Epigenetic regulation affects cancer cell death mainly by upregulating or downregulating key cell death proteins, thereby influencing the expression levels of critical regulators.\"},{\"question\":\"Which cell death modalities are emphasized beyond classic programmed death?\",\"answer\":\"The document focuses on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis, describing them as newly recognized modes with increasing attention for their effects on tumor progression.\"},{\"question\":\"What main mechanisms are linked to ferroptosis and cuproptosis?\",\"answer\":\"Ferroptosis and cuproptosis are attributed to disrupted metal homeostasis, Fe2+ and Cu+ imbalance, which alters signaling pathways relevant to cancer development.\"}]","Epigenetic regulation of diverse cell death modalities in cancer - a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis | PDF",1789989099]