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Non-coding RNAs (ncRNAs) regulate cancer-related pathways, and abnormal cross-talk between histone modifications and ncRNAs is reported across diverse cancer types. This review systematically examines how histone modifications and ncRNAs drive the pathogenesis of digestive system cancers, including effects on proliferation, migration, angiogenesis, and other tumor-cell behaviors. It also highlights diagnostic and prognostic markers, therapeutic targets, and chemoradiation-resistance insights from an epigenetic perspective.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/epigenetic-modifications-involving-ncrnas-in-digestive-system-cancers-focus-on-histone-modification/332772/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/epigenetic-modifications-involving-ncrnas-in-digestive-system-cancers-focus-on-histone-modification/332772.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-11","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How do histone modifications contribute to digestive system cancers?","Question",{"text":113,"@type":114},"Histone modifications represent a key epigenetic mechanism and are strongly linked to tumor development. 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Clinical Epigenetics (2024) 16:162 [https://doi.org/10.1186/s13148-024-01773-0](https://doi.org/10.1186/s13148-024-01773-0)  \nClinical Epigenetics  \n REVIEW Open Access  \nEpigenetic modifications involving ncRNAsin digestive system cancers: focus on histone modification  \nXiaodi Yin1†, Jingyi Li2†, Jiahui Zhao1, Weihan Zheng1, Aohua Zhang1 and Jun Ma 1*  \nAbstract  \nIn recent years, epigenetic modifications have been strongly linked to tumor development, with histone modifications representing a key epigenetic mechanism. In addition, non-coding RNAs (ncRNAs) play a critical role in regulating cancer-related pathways. The abnormal interaction between histone modifications and ncRNAs, both pivotal epigenetic regulators, has been widely observed across various cancer types. Here, we systematically explore the molecular mechanisms through which histone modifications and ncRNAs contribute in the pathogenesis of digestive system cancers, and aberrant ncRNA-mediated histone modifications manipulate various biological behaviors of tumor cells including proliferation, migration, angiogenesis, etc. In addition, we provide new insights into diagnostic, prognostic markers, therapeutic targets and chemoradiation resistance for digestive system cancers from the epigenetic perspective.  \nIntroduction  \nDigestive system cancers (DSCs) represent a substantial proportion of all cancers, and continue to be a major global public health concern. As stated by Global Cancer Statistics 2020, DSCs account for approximately 50% of all cancers worldwide, including nearly 6 million cases of malignant tumors of the digestive system [1]. DSCs include hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), gastric carcinoma (GC), pancreatic carcinoma (PC), esophageal carcinoma (EC), head and neck squamous cell carcinoma (HNSCC), tongue and oral squamous cell carcinoma (TSCC), and gallbladder cancer. The primary treatment options for DSCs are  \n†Xiaodi Yin and Jingyi Li contributed equally to this work.  \n*Correspondence: Jun Ma[majun@zzu.edu.cn](majun@zzu.edu.cn)  \n1 Department of Clinical Laboratory, The Second Affiliated Hospital of Zhengzhou University, \\#2 Jingba Road, Zhengzhou 450014, China  \n2 Intensive Care Medicine, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China  \nradiotherapy and chemotherapy [2], while the insidious onset of digestive system tumors and the lack of specific symptoms and signs often result in poor treatment outcomes [3], Consequently, recurrence and metastasis rates remain high, and the overall prognosis for patients is unfavorable [4]. Thus, the development of new treatment methods for patients with digestive system cancers is an urgent and unmet clinical need.  \nIn the last 30 years, numerous forms of RNA have been identified by researchers, but ncRNA—the kind that isn’t involved in creating proteins—is one of the most important types [5]. Many ncRNAs have been verified to take crucial parts in transcriptional regulation, and regulation of proteins or RNA molecules [6]. The main classes of ncRNAs include long non-coding RNAs (lncRNA), microRNAs (miRNA), circular RNAs (circRNA), and Piwi-interacting RNAs (piRNA). NcRNAs can influence the health of the digestive system in terms of regulating gene expression, cell signaling pathways and epigenetic mechanisms. For example, ncRNAscan play a pro-inflammatory or anti-inflammatory role in the pathogenesis of IBD by modulating the function of  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived ","cbCaiqgRIy2OOdtA","https://ap.wps.com/l/cbCaiqgRIy2OOdtA","pdf",3848528,22,"English","# Abstract\n# Introduction","[{\"question\":\"How do histone modifications contribute to digestive system cancers?\",\"answer\":\"Histone modifications represent a key epigenetic mechanism and are strongly linked to tumor development. They influence tumor-cell behaviors through epigenetic regulation within cancer-related pathways.\"},{\"question\":\"What role do non-coding RNAs (ncRNAs) play in these cancers?\",\"answer\":\"ncRNAs regulate cancer-related pathways and can act as oncogenes or tumor suppressor genes in digestive system cancers. They participate in transcriptional regulation and also affect protein or RNA-related regulatory processes.\"},{\"question\":\"How are histone modifications and ncRNAs connected in cancer mechanisms?\",\"answer\":\"Abnormal interactions between histone modifications and ncRNAs are widely observed across cancer types. ncRNA-mediated histone modifications can manipulate multiple biological behaviors of tumor cells and may contribute to processes such as progression and resistance.\"}]","Epigenetic modifications involving ncRNAs in digestive system cancers - focus on histone modification | PDF",1789999455,55]