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Altered miRNA expression can arise from epigenetic mechanisms, chromosomal changes, genetic polymorphisms, or defects in miRNA processing proteins. Epigallocatechin-3-gallate (EGCG), a phytochemical, shows epigenetic anticancer actions, influencing processes such as apoptosis, proliferation, angiogenesis, and metastasis by silencing specific miRNAs including let-7, miR-16, and miR-210. Differential miRNA responses to EGCG suggest therapeutic potential, motivating this review to summarize current evidence for EGCG as a miRNA modulator to enhance existing cancer treatments.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/epigallocatechin-3-gallate-and-cancer-focus-on-the-role-of-micrornas/381748/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/epigallocatechin-3-gallate-and-cancer-focus-on-the-role-of-micrornas/381748.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What are microRNAs and why are they important in cancer?","Question",{"text":113,"@type":114},"MicroRNAs are small non-coding RNAs that regulate gene expression. 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Cancer Cell International (2023) 23:241  \n[https://doi.org/10.1186/s12935-023-03081-8](https://doi.org/10.1186/s12935-023-03081-8)  \nCancer Cell International  \n REVIEW Open Access  \nEpigallocatechin-3-gallate and cancer: focus on the role of microRNAs  \nChunguang Wang1, Meiling Bai2*, Zhiguang Sun1, Nan Yao1, Aiting Zhang1, Shengyu Guo1 and Zatollah Asemi3*  \nAbstract  \nMicroRNAs (miRNAs) are a group of small non-coding RNAs that affect gene expression. The role of miRNAs in different types of cancers has been published and it was shown that several miRNAs are inappropriately expressed in different cancers. Among the mechanisms that can cause this lack of proper expression are epigenetics, chromosomal changes, polymorphisms or defects in processing proteins. Recent research shows that phytochemicals, including epigallocatechin-3-gallate (EGCG), exert important epigenetic-based anticancer effects such as pro-apoptoticor anti proliferative through miRNA gene silencing. Given that EGCG is able to modulate a variety of cancer-related process i. e., angiogenesis, proliferation, metastasis and apoptosis via targeting various miRNAs such as let-7, miR-16, and miR-210 . The discovery of new miRNAs and the differences observed in their expression when exposed to EGCG provides evidence that targeting these miRNAs may be beneficial as a form of treatment. In this review, we aim to provide an overview, based on current knowledge, on how phytochemicals, including epigallocatechin-3-gallate, can be considered as potential miRNAs modulator to improve efficacy of current cancer treatments.  \nKeywords Cancer, Epigallocatechin-3-gallate, Epigenetic, MicroRNAs, Molecular pathways  \nIntroduction  \nThe World Health Organization’s Global Cancer Report suggests that, in addition to breast and lung cancer posing a considerable risk to human life and health, we may also be seeing an upswing in the number of gastric, colorectal, liver, and prostate cancer cases. It is predicted that by 2040, the global burden of cancer will be 50% higher than it is today, with 30 million new cases annually  \n*Correspondence: Meiling Bai [blxiaobai2022@126.com](blxiaobai2022@126.com)[ ](blxiaobai2022@126.com)Zatollah Asemi [asemi_r@yahoo.com](asemi_r@yahoo.com)  \n1 The First Affiliated Hospital of Hebei North University, Zhang Jiakou 075000, Hebei, China  \n2 Basic Medical College of Hebei North University, Zhang Jiakou 075000, Hebei, China  \n3 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran  \n[1–3]. Although there are various treatments available for cancer, the results are far from satisfactory [4]. Chemotherapy drugs such as cisplatin, doxorubicin and even radiotherapy are frequently used in the management of many cancer cases, often causing negative side effects and severe toxicity. Radiotherapy furthermore has the risk of leading to impairments in memory, learning, and cognitive abilities, and may result in decreased brain functioning later in life [5]. In addition to the risk of developing a secondary tumor due to chemotherapy, there are also potential side effects resulting from damage to healthy tissues. In response to this, plant-derived compounds, such as alkaloids, terpenoids, phenols, flavonoids, and more, have proven to be effective in preventing and treating certain cancers, such as breast cancer lung cancer, and ovarian cancer. These compounds influence the inflammatory processes, cause cell apoptosis, inhibit the invasion and metastasis of cancer cells, and reduce the immune system’s tolerance of tumors [6].  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to","cbCaipBsbk0Hpk8M","https://ap.wps.com/l/cbCaipBsbk0Hpk8M","pdf",1618357,"English","# Abstract\n# Introduction\n# EGCG and green tea polyphenols\n# miRNAs and gene regulation","[{\"question\":\"What are microRNAs and why are they important in cancer?\",\"answer\":\"MicroRNAs are small non-coding RNAs that regulate gene expression. In cancers, some miRNAs are inappropriately expressed, which can contribute to altered cellular processes.\"},{\"question\":\"How does epigallocatechin-3-gallate (EGCG) act against cancer?\",\"answer\":\"EGCG exerts epigenetic-based anticancer effects and can influence multiple cancer-related processes. It modulates pathways by targeting and silencing various miRNAs.\"},{\"question\":\"Which miRNAs are mentioned as being targeted by EGCG?\",\"answer\":\"The document cites miRNAs such as let-7, miR-16, and miR-210 as examples that EGCG can target through miRNA-related gene silencing.\"}]","Epigallocatechin-3-gallate and cancer - focus on the role of microRNAs | PDF",1790246873,33]