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A retrospective investigation analyzed 50 hospitalized cases diagnosed between 2009 and 2019 in a single institution to define a clinical-morphological profile in the served geographical area. Men over 50 predominated, with the tongue most frequently affected, followed by lips and oral floor. Histopathology showed conventional OSCC as most common, with TNM distribution concentrated in stages II and IV, and muscle invasion and perineural invasion occurring in a substantial proportion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/epidemiological-and-histopathological-features-of-oral-squamous-cell-carcinoma-a-retrospective-study/329447/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/epidemiological-and-histopathological-features-of-oral-squamous-cell-carcinoma-a-retrospective-study/329447.png","ImageObject",300,407,{"name":92,"@type":93},"Seraphina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What study design and time period were used to evaluate OSCC cases?","Question",{"text":112,"@type":113},"The study used a retrospective design analyzing 50 oral squamous cell carcinoma cases diagnosed between 2009 and 2019 at the institution.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which patient and tumor characteristics were highlighted in the epidemiological findings?",{"text":117,"@type":113},"Epidemiological results showed predominance of cases in men over 50 years old, mainly involving the tongue, then the lips and oral floor.",{"name":119,"@type":110,"acceptedAnswer":120},"What histopathological patterns and staging results were reported?",{"text":121,"@type":113},"Histopathology showed conventional OSCC as the majority, with additional rarer forms; differentiation was often moderately differentiated, and most cases were diagnosed in TNM stages II and IV.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329447,1790193948,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Original Paper  \nEpidemiological and Histopathological Features of Oral Squamous Cell Carcinoma-A Retrospective Study  \nIONUŢ-OCTAVIAN I LIE 1 , OTILIA CLARA MĂRGĂRITESCU2 , ALEX EMILIAN STEPAN3 , RALUCA NICULINA CIUREA3 , MIRELA MARINELA FLORESCU3 , CRISTINA MUNTEANU4 , MIRCEA-SEBASTIAN ŞERBĂNESCU5 , CLAUDIU MĂRGĂRITESCU2  \n1PhD student, Department of Morphopathology, University of Medicine and Pharmacy of Craiova, Romania  \n2Department of Neurosurgery, University of Medicine and Pharmacy of Craiova, Romania  \n3Department of Morphopathology, University of Medicine and Pharmacy of Craiova, Romania  \n4Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, Romania  \n5Medical Informatics and Biostatistics Department, University of Medicine and Pharmacy of Craiova, Romania  \nABSTRACT: Oral Squamous Cell Carcinoma (OSCC) it was reported to be the 6th on the list of human malignant neoplasms responsible for high morbidity and mortality worldwide. We conducted a retrospective study between 2009-2019, investigating 50 such cancers hospitalized and diagnosed during this period in our institution. The purpose of the study was to establish a clinical-morphological profile of this type of cancer developed in the geographical area served by our institution. The epidemiological study highlighted the predominance of cases in men over 50 years old, mainly affecting the tongue, followed by the lips and oral floor. The histopathological study showed the prevalence of conventional cases of OSCC (70%) and the rest of the cases belonging to rarer forms (acantholytic-18%, verrucous-6%, basaloid-4% and sarcomatoid-2%) . In terms of the degree of differentiation, the moderately differentiated cases prevailed (64%) and according to the TNM clinical stage, most cases were diagnosed in stage II (36%) and IV (26%) . 70% of investigated cases presented muscle invasion and 38% perineural invasion. Our investigation highlighted the existence of particular morpho-clinical profiles depending on the tumor topography. Thus , tumors developed at the tongue level reached the maximum frequency in the 6th decade of life, being absent in the 8th decade and most often associated muscle invasion and perineural invasion, being diagnosed in advanced pTNM stages.  \nKEYWORDS: Epidemiology, Histopathology, Oral cavity, Oral squamous cell carcinomas.  \nIntroduction  \nIn the European demographic space, malignant neoplasms of the head and neck amount to 4% of all cancers. In 2012, there were approximately 140,000 new cases of oralsquamous cell carcinoma and around 63,500 deaths due to this form of oral malignancy [1] .  \nAccording to the latest statistics provided by GLOBOCAN regarding malignant neoplasms of the oral cavity and lips, this form of cancer is the sixth most common worldwide, reporting for the year 2020, approximately 377,713 new cases of oral squamous cell carcinoma and around 177,757 deaths due to them [2] .  \nSquamous cell carcinoma of the mucosa of the oral cavity has an exceptional morbidity and mortality considering the many functions in which this mucosa participates. Thus, the 5-year survival in localized clinical forms of the disease is between 75-84% . In advanced clinical forms accompanied by metastasis, the survival over the same period of time is 20%(location: floor of the oral cavity) and 36%(location: tongue) [3] .  \nDespite the progress achieved in the last period of time, the showing up of improved diagnostic techniques, the discovery of new therapies, as well as new management protocols for head and neck cancer, the prognosis of these patients still remains reserved, not changing significantly in the last three decades, the 5-year survival rate remains around 50-60%[4] .  \nOver time, numerous studies have been carried out regarding the identification of the most feasible prognostic, clinical and histopathological parameters of oral squamous cell carcinomas, highlighting as more important: tumor size, lymph ","cbCaicEg4vPjTfXR","https://ap.wps.com/l/cbCaicEg4vPjTfXR","pdf",1439044,"English","# Abstract\n# Introduction\n# Materials and Methods","[{\"question\":\"What study design and time period were used to evaluate OSCC cases?\",\"answer\":\"The study used a retrospective design analyzing 50 oral squamous cell carcinoma cases diagnosed between 2009 and 2019 at the institution.\"},{\"question\":\"Which patient and tumor characteristics were highlighted in the epidemiological findings?\",\"answer\":\"Epidemiological results showed predominance of cases in men over 50 years old, mainly involving the tongue, then the lips and oral floor.\"},{\"question\":\"What histopathological patterns and staging results were reported?\",\"answer\":\"Histopathology showed conventional OSCC as the majority, with additional rarer forms; differentiation was often moderately differentiated, and most cases were diagnosed in TNM stages II and IV.\"}]","Epidemiological and Histopathological Features of Oral Squamous Cell Carcinoma - A Retrospective Study | PDF",1789984159,25]