[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31580":3,"doc-seo-31580":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31580,8796095461610,"Oliver","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",8,"Research & Report","Environmentally Responsive Fe3O4@HKUST-1 MOF as a Platform for Synergistic Chemo-Photothermal Therapy in Cancer Treatment","Nanocarrier platforms combining photothermal and chemotherapeutic modalities offer a promising route for anti-tumor treatment by exploiting the tumor microenvironment. This work develops an Fe3O4@HKUST-1 system where the MOF HKUST-1 serves as a drug carrier and Fe3O4 provides photothermal functionality. The carrier achieves a high Doxorubicin loading rate and efficient near-infrared (980 nm) photothermal conversion. pH-sensitive release accelerates drug liberation in acidic tumor conditions. In vitro biocompatibility and cell-viability results show stronger growth inhibition with combined chemo-photothermal therapy than photothermal therapy alone.","cbCaimhDF81sw9ep","https://ap.wps.com/l/cbCaimhDF81sw9ep","pdf",9116478,1,15,"English","en","# Introduction\n## Nanocarriers and tumor microenvironment targeting\n## MOFs as drug delivery platforms\n## HKUST-1 properties and prior work\n## Photothermal therapy and Fe3O4 rationale","[{\"question\":\"What therapeutic strategy does the Fe3O4@HKUST-1 platform support?\",\"answer\":\"It supports synergistic chemo-photothermal therapy by combining chemotherapy delivery with photothermal heating under near-infrared light.\"},{\"question\":\"How is drug release triggered in the proposed nanocarrier?\",\"answer\":\"Drug release is accelerated by pH sensitivity, designed to respond to acidic conditions in the tumor microenvironment.\"},{\"question\":\"How does the combined treatment compare with photothermal therapy alone?\",\"answer\":\"Photothermal therapy alone leaves tumor cell viability around 80%, while chemo-photothermal combination reduces viability to about 30%, inhibiting proliferation more effectively.\"}]",1779742934,38,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"environmentally-responsive-fe3o4hkust-1-mof-as-a-platform-for-synergistic-chemo-photothermal-therapy-in-cancer-treatment","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/environmentally-responsive-fe3o4hkust-1-mof-as-a-platform-for-synergistic-chemo-photothermal-therapy-in-cancer-treatment/31580/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-25",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What therapeutic strategy does the Fe3O4@HKUST-1 platform support?","Question",{"text":73,"@type":74},"It supports synergistic chemo-photothermal therapy by combining chemotherapy delivery with photothermal heating under near-infrared light.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How is drug release triggered in the proposed nanocarrier?",{"text":78,"@type":74},"Drug release is accelerated by pH sensitivity, designed to respond to acidic conditions in the tumor microenvironment.",{"name":80,"@type":71,"acceptedAnswer":81},"How does the combined treatment compare with photothermal therapy alone?",{"text":82,"@type":74},"Photothermal therapy alone leaves tumor cell viability around 80%, while chemo-photothermal combination reduces viability to about 30%, inhibiting proliferation more effectively.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]