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This study develops a non-invasive home-based intervention that rehabilitates theta (4–8 Hz) and gamma (30–50 Hz) neural oscillations using self-selected music combined with synchronized light pulses. A Phase I clinical trial in mild cognitive impairment and early-stage AD compares gMBI with a health-education podcast control, using pre/post EEG, MRI, DTI, fMRI, blood draws, and cognitive testing. After 8 weeks, neural oscillations strengthen, hippocampal activation increases, and memory and cognition are better preserved in the treatment group.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/entrain-in-the-brain-with-music-and-synchronized-light-to-improve-memory-and-preserve-cognitive-function-phase-i-clinical-trial/424719/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/entrain-in-the-brain-with-music-and-synchronized-light-to-improve-memory-and-preserve-cognitive-function-phase-i-clinical-trial/424719.png","ImageObject",300,407,{"name":92,"@type":93},"jay","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are non-invasive interventions being explored for Alzheimer’s disease?","Question",{"text":112,"@type":113},"Pharmacological treatments have not produced significant effects on memory, cognition, and behavior, and they can cause potentially dangerous side effects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the music-and-light intervention work in this study?",{"text":117,"@type":113},"The approach targets theta (4–8 Hz) and gamma (30–50 Hz) neural oscillations using self-selected music together with synchronized light pulses.",{"name":119,"@type":110,"acceptedAnswer":120},"What tests are conducted before and after the 8-week therapy?",{"text":121,"@type":113},"Participants undergo EEG, structural MRI, diffusion tensor imaging, functional MRI, blood draws, and cognitive and memory assessments before and after the intervention.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},424719,1791045915,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},3985747858866,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Innovation in Aging, 2025, Vol. 9, No. S2 1285  \nBiosciences, Willington, Connecticut, United States,  \n3. Northeastern University, Boston, Massachusetts, United States Worldwide at least 57 million individuals are currently living  \nwith Alzheimer’s disease (AD), and by 2050 nearly 13 million Americans are projected to have AD. Pharmacological interventions have not been successful in producing significant effects on memory, cognition and behavior, and all pharmaceuticals carry some risk of potentially dangerous side effects. Recent research suggests that rehabilitation of neural oscillations supporting memory and cognition may provide effective treatments for neurological disorders such as AD. However, there are significant challenges in developing non-invasive, feasible, effective and scalable methods for human intervention. We have developed an intervention to rehabilitate theta (4-8Hz) and gamma (30-50Hz) neural oscillations using self-selected music and synchronized light pulses. We are currently running a Phase I Clinical Trial (NCT05984524) in individuals with Mild Cognitive impairment (MCI) and early-stage AD. Our gamma-enhanced music-based intervention (gMBI) is administered in the patient’s home 30 minutes/day for 8 weeks; the control intervention includes listening to a health education podcast (the health-education intervention, HEI). Before and after the therapy patients undergo a battery of tests, including electroencephalography (EEG), structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI), functional MRI (fMRI), blood draws, and tests of cognition and memory. Patient usage data in both conditions is monitored. We find that patients comply better with the treatment protocol than with the control protocol. After 8 weeks, neural oscillations are strengthened, hippocampal activation increases, memory improves, and cognitive function is preserved in the treatment group relative to controls. Patient recruitment is ongoing.  \nAbstract citation ID: igaf122.4286  \nENTRAINING THE BRAIN WITH MUSIC AND  \nSYNCHRONIZED LIGHT TO IMPROVE MEMORY AND  \nPRESERVE COGNITIVE FUNCTION  \nEdward Large1, Ji Chul Kim2, and Psyche Loui3, 1. Oscillo Biosciences, Storrs, Connecticut, United States, 2. Oscillo","cbCaigYbkVVVxLDg","https://ap.wps.com/l/cbCaigYbkVVVxLDg","pdf",1126366,"English","# Study Rationale\n## Limitations of pharmacological interventions\n# Intervention Design\n## Theta and gamma neural oscillation rehabilitation\n## Home-based synchronized music and light\n# Phase I Clinical Trial\n## Participants: MCI and early-stage AD\n## Control condition: health education podcast\n# Outcome Measures\n## EEG, MRI, DTI, fMRI, blood draws, cognition tests\n# Results and Ongoing Recruitment\n## Compliance, neural and hippocampal changes, cognitive preservation","[{\"question\":\"Why are non-invasive interventions being explored for Alzheimer’s disease?\",\"answer\":\"Pharmacological treatments have not produced significant effects on memory, cognition, and behavior, and they can cause potentially dangerous side effects.\"},{\"question\":\"How does the music-and-light intervention work in this study?\",\"answer\":\"The approach targets theta (4–8 Hz) and gamma (30–50 Hz) neural oscillations using self-selected music together with synchronized light pulses.\"},{\"question\":\"What tests are conducted before and after the 8-week therapy?\",\"answer\":\"Participants undergo EEG, structural MRI, diffusion tensor imaging, functional MRI, blood draws, and cognitive and memory assessments before and after the intervention.\"}]","Entrain in the Brain with Music and Synchronized Light to Improve Memory and Preserve Cognitive Function - Phase I Clinical Trial | PDF",1790635161]