[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338359-105":59,"doc-detail-338359-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","enhancing-prognostic-accuracy-in-predicting-rectal-neuroendocrine-neoplasms","Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms","","The editorial discusses the clinical value of the GATIS score introduced by a newly published retrospective study on rectal neuroendocrine neoplasms. Using data from a large Chinese multicenter cohort, the score integrates tumor grade, T stage, tumor size, age, and prognostic nutritional index to improve prediction of overall survival and progression-free survival compared with traditional WHO grading and TNM staging. 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It is highlighted as improving prognostic accuracy for overall survival and progression-free survival compared with traditional grading and staging systems.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which variables are incorporated into the GATIS score?",{"text":117,"@type":113},"The editorial notes that the score includes tumor grade, T stage, tumor size, age, and prognostic nutritional index (PNI). These components are used to estimate survival and disease progression outcomes.",{"name":119,"@type":110,"acceptedAnswer":120},"What limitations does the editorial identify and what future work is suggested?",{"text":121,"@type":113},"The editorial points to limitations such as relatively short follow-up durations and the exclusion of molecular and genetic factors. 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By analyzing data from a large Chinese multicenter cohort, the study shows that the GATIS score, incorporating tumor grade, T stage, tumor size, age, and prognostic nutritional index, demonstrates superior predictive power for overall survival and progression-free survival compared to traditional World Health Organization grade and tumor, nodes and metastases staging systems. This editorial aims to discuss the importance of the GATIS score, its potential impact on clinical practice, and the strengths and limitations of the study. Finally, it explores the significance, methodology, and clinical implications of these findings.  \nKey Words: Rectal neuroendocrine neoplasm; Nomogram; Random forest; Prognosis; Overall survival; Progression-free survival  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: The GATIS score, developed from a 12-year study of 1408 patients with rectal neuroendocrine neoplasms (R-NENs) across 17 major Chinese centers, predicts overall survival and progression-free survival more accurately than World Health Organization grade and tumor-node-metastasis staging. This score offers improved personalized patient management and treatment planning. However, the study includes limitations such as short follow-up durations and exclusion of molecular and genetic factors. Addressing these in future research could further enhance treatment strategies for RNENs.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 4087 October 7, 2024  Volume 30  Issue 37   \nRaj RPA et al. GATIS score for R-NENs  \nCitation: Raj RPA, Nashwan AJ. Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms. World JGastroenterol 2024; 30(37): 4087-4089  \nURL: [https://www.wjgnet.com/1007-9327/full/v30/i37/4087.htm](https://www.wjgnet.com/1007-9327/full/v30/i37/4087.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v30.i37.4087](https://dx.doi.org/10.3748/wjg.v30.i37.4087)  \nINTRODUCTION  \nNeuroendocrine neoplasms (NENs) are a diverse group of cancers originating from neuroendocrine cells. According to the 2022 World Health Organization (WHO) classification of endocrine and neuroendocrine tumors (NETs), NENs are classified into three groups: Well-differentiated NETs, poorly differentiated neuroendocrine carcinomas (commonly referred to as NECs), and mixed neuroendocrine-non-NENs. NETs are generally graded as G1, G2, and G3 based on thei","cbCaioCbXalK84c3","https://ap.wps.com/l/cbCaioCbXalK84c3","pdf",337896,"English","# Abstract\n## Core Tip\n# Introduction","[{\"question\":\"What is the GATIS score and why is it important for rectal neuroendocrine neoplasms?\",\"answer\":\"The GATIS score is a predictive model developed from clinical and pathological factors for rectal neuroendocrine neoplasms. It is highlighted as improving prognostic accuracy for overall survival and progression-free survival compared with traditional grading and staging systems.\"},{\"question\":\"Which variables are incorporated into the GATIS score?\",\"answer\":\"The editorial notes that the score includes tumor grade, T stage, tumor size, age, and prognostic nutritional index (PNI). These components are used to estimate survival and disease progression outcomes.\"},{\"question\":\"What limitations does the editorial identify and what future work is suggested?\",\"answer\":\"The editorial points to limitations such as relatively short follow-up durations and the exclusion of molecular and genetic factors. It suggests that addressing these issues in future research could refine treatment strategies for rectal neuroendocrine neoplasms.\"}]","Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms | PDF",1790023238]