[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-127189-en":3,"doc-seo-127189-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},127189,549768072016,"River Wang","https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",8,"Research & Report","Enhancing Kidney Transplantation Outcomes Through Precision Immunosuppressive Therapy - A Machine Learning Approach","This dissertation develops and evaluates a machine learning approach to enhance kidney transplantation outcomes through more precise immunosuppressive therapy. It addresses clinical challenges in tailoring immunosuppression, motivating a data-driven treatment strategy aligned with transplant needs. The work defines the study problem, purpose, research questions, and significance, then reviews immunosuppressive therapies and desensitization strategies to establish context. It combines computational science methods with translational transplant considerations to support improved therapeutic decision-making.","ENHANCING KIDNEY TRANSPLANTATION OUTCOMES THROUGH PRECISION IMMUNOSUPPRESSIVE THERAPY: A MACHINE LEARNING  \nAPPROACH  \nby  \nKunle Timothy Apanisile  \nA Dissertation  \nSubmitted to the  \nGraduate Faculty  \nof  \nGeorge Mason University  \nin Partial Fulfillment of  \nThe Requirements for the Degree  \nof  \nDoctor of Philosophy  \nComputational Sciences and Informatics  \nCommittee:  \n  Dr. Jason Kinser, Dissertation Director   Dr. Naoru Koizumi, Committee Member   Dr. Ali Andalibi Committee Member   Dr. Anamaria Berea, Committee Member   Dr. Jason Kinser, Department Chairperson  \n  Dr. Gerald L. R. Weatherspoon, Associate  \nDean for Undergraduate and Graduate Affairs, College of Science  \n  Dr. Fernando R. Miralles-Wilhelm, Dean,  \nCollege of Science  \nDate:   Spring Semester 2024  \nGeorge Mason University  \nFairfax, VA  \nEnhancing Kidney Transplantation Outcomes Through Precision Immunosuppressive  \nTherapy: A Machine Learning Approach  \nA Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at George Mason University  \nby  \nKunle Timothy Apanisile  \nMaster of Arts  \nEastern Illinois University, 2019  \nBachelor of Science  \nLagos State University, 2011  \nDirector: Jason Kinser, Associate Professor  \nChair, Computational and Data Sciences  \nSpring Semester 2024  \nGeorge Mason University  \nFairfax, VA  \nCopyright 2024 Kunle Timothy Apanisile All Rights Reserved  \nDEDICATION  \nI dedicate this work to the Almighty God, the ultimate source of inspiration and divine wisdom. I extend my deepest gratitude to my wife and siblings for their unwavering support, which has been instrumental in ensuring the successful completion of this research work.  \nACKNOWLEDGMENTS  \nI extend my sincere gratitude to my advisor, Dr. Koizumi, for her unwavering guidance and support throughout this journey. I am also immensely thankful to the members of my committee, Dr. Kinser, Dr. Berea, and Dr. Andalibi, for their invaluable input and boundless patience. Additionally, I would like to express my appreciation to the Department of Computational and Data Sciences for granting me a graduate research assistantship, which has greatly facilitated my academic pursuits.  \nTABLE OF CONTENTS  \nPage  \nList of Tables ................................................................................................................... viii  \nList of Figures .................................................................................................................... ix  \nList of Equations ................................................................................................................. x  \nList of Abbreviations ......................................................................................................... xi  \nAbstract ............................................................................................................................ xiv  \nChapter One ........................................................................................................................ 1  \n1.1 Background and Motivation...................................................................................... 1  \n1.2 Statement of the Problem .......................................................................................... 8  \n1.3 Purpose of the Study ................................................................................................. 8  \n1.4 Research Questions ................................................................................................... 9  \n1.5 Significance of the Study .......................................................................................... 9  \nChapter Two...................................................................................................................... 10  \n2.1 The Need for Immunosuppressive Therapies in Kidney Transplantation............... 10  \n2.2 Desensitization Therapy Strategy..............................................","cbCainN3wvnCZcDR","https://ap.wps.com/l/cbCainN3wvnCZcDR","pdf",2978555,1,183,"English","en",105,"# List of Tables\n# List of Figures\n# List of Equations\n# List of Abbreviations\n# Abstract\n# Chapter One\n## Background and Motivation\n## Statement of the Problem\n## Purpose of the Study\n## Research Questions\n## Significance of the Study\n# Chapter Two\n## The Need for Immunosuppressive Therapies in Kidney Transplantation\n## Desensitization Therapy Strategy\n## Immunosuppressive Therapy","[{\"question\":\"What is the study’s main goal?\",\"answer\":\"The dissertation aims to enhance kidney transplantation outcomes by using a machine learning approach to support precision immunosuppressive therapy decisions.\"},{\"question\":\"What motivates the research?\",\"answer\":\"The work highlights the need for immunosuppressive therapy in kidney transplantation and the challenge of selecting appropriate strategies, leading to the stated background and motivation.\"},{\"question\":\"Which therapy areas are covered in the dissertation?\",\"answer\":\"The document reviews desensitization therapy strategies (including intravenous immunoglobulins, rituximab, plasmapheresis and immunoadsorption, and complement inhibitors) and broader immunosuppressive therapy options for maintenance and induction.\"}]","Enhancing Kidney Transplantation Outcomes Through Precision Immunosuppressive Therapy - 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