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Six participants wore the gloves, with adherence recorded, and underwent functional testing at baseline and at 1 and 2 weeks. Adverse events were rare (\u003C5%) and mild, with no major safety concerns. 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Phys. Ther. Sci. 38: 14–18, 2026  \nThe Journal of Physical Therapy Science  \nOriginal Article  \nEnhancing hand function in patients with hematologic malignancies: a novel knitted glove approach  \nHaruki Mori1)a, Tomoo Mano1, 2)a*, Saho Nakajima1), Moeko Sei1), Takashi Masuda1)  \n1) Department of Rehabilitation, Nara Prefecture General Medical Center, Japan  \n2) Department of Neurology, Nara Medical University: 840 Shijo-cho, Kashihara, Nara 634-8521, Japan  \nAbstract. [Purpose] Patients with hematologic malignancies frequently experience hand function decline due to disease progression and adverse effects of chemotherapy and hematopoietic stem cell transplantation. Given the critical importance of daily hand function, effective rehabilitation strategies are essential. This study evaluated the feasibility and safety of a novel knitted hand function enhancement glove designed for routine use. [Participants and Methods] Six hospitalized patients undergoing chemotherapy or bone marrow transplantation voluntarily participated by wearing gloves and recording wear time. Functional assessments, including grip strength, pinch strength, and the Box and Block Test, were performed at baseline and at 1 and 2 weeks post-intervention. [Results] Adverse events occurred in less than 5% of patients and comprised mild skin irritation and temporary numbness. A significant improvement was observed in the Box and Block Test after wearing hand function enhancement gloves, whereas grip strength and pinch strength showed no significant changes. Compliance was strongly correlated with functional improvement, suggesting a potential role of the glove in passive rehabilitation. [Conclusion] This knitted glove may serve as a practical, low-impact rehabilitation tool for safely maintaining finger dexterity during hospitalization. Further investigation is warranted to evaluate its long-term efficacy.  \nKey words: Hand function, Hand function enhancement glove, Novel knitted glove  \n(This article was submitted Jun. 23, 2025, and was accepted Oct. 17, 2025)  \nINTRODUCTION  \nPatients with hematologic malignancies are known to experience a decline in hand strength due to underlying primary diseases and side effects of treatments, such as hematopoietic stem cell transplantation and chemotherapy. Hand function is associated with daily activities and is essential for tasks such as opening bottles or fastening buttons; therefore, functional changes in the hands can markedly affect the quality of life. Rehabilitation exercises, such as hand grip training, are commonly prescribed for patients with diminished hand function. However, these approaches require active patient participation, which may be challenging for individuals experiencing treatment-related side effects from procedures such as hematopoietic stem cell transplantation and chemotherapy.  \nAlthough wearable devices for independent training exist, most are made of metals and require a considerable time commitment. Their long-term use has been associated with adverse effects, such as tingling sensations, numbness, and discoloration of the fingertips, raising concerns about their safety and sustainability. Moreover, because these devices are metallic, users often find it difficult to perform daily activities without being constantly conscious, highlighting the need for training methods that can be safely implemented over extended periods.  \naCo-first authors, contributed equally.  \n*Corresponding author. Tomoo Mano ([E-mail: manoneuro@naramed-u.ac.jp](E-mail: manoneuro@naramed-u.ac.jp))©2026 The Society of Physical Therapy Science. Published by IPEC Inc.  \nThis is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: [https://creativecommons.org/licenses/by-nc-nd/4.0/](https://creativecommons.org/licenses/by-nc-nd/4.0/))  \nFig. 1. A glove designed to enhance hand functionality, sewn togeth  \ner with stretch","cbCailR6Jio1xPPn","https://ap.wps.com/l/cbCailR6Jio1xPPn","pdf",892844,"English","# Abstract\n# Introduction\n# Participants and Methods","[{\"question\":\"What was the purpose of using the knitted glove in this study?\",\"answer\":\"To evaluate feasibility and safety of a novel knitted glove intended to enhance hand function during hospitalization for patients with hematologic malignancies.\"},{\"question\":\"How were participants and interventions structured?\",\"answer\":\"Six hospitalized patients wore the gloves and recorded wear time; grip strength, pinch strength, and the Box and Block Test were assessed at baseline and at 1 and 2 weeks.\"},{\"question\":\"What improvements and safety outcomes were observed?\",\"answer\":\"Adverse events occurred in less than 5% of patients and were mild (e.g., skin irritation, temporary numbness). Box and Block Test improved significantly, while grip strength and pinch strength showed no significant changes; higher compliance correlated with functional improvement.\"}]","Enhancing hand function in patients with hematologic malignancies - a novel knitted glove approach | PDF",1790663622,13]