[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31481":3,"doc-seo-31481":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31481,2336464648322,"Aria","https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488",8,"Research & Report","Engineering of Surface-Modified CuBTC-MXene Nanocarrier for Adsorption and Co-Loading of Curcumin/Paclitaxel from Aqueous Solutions for Synergistic Multi-Therapy of Cancer","Two-dimensional nanomaterials are leveraged to enhance drug delivery by lowering toxicity, improving bioavailability, and increasing therapeutic performance. This study evaluates MXenes formed from transition metal carbides/nitrides together with a Cu(II) benzene-1,3,5-tricarboxylate metal–organic framework (Cu-BTC) as nanocarriers for loading and delivering curcumin (CUR) and paclitaxel (PTX) to cancer cells. Surface termination effects (bare vs oxygen) are examined for adsorption, and co-loading behavior is assessed via interaction energy and simulation equilibrium trends, supporting strong CUR adsorption and effective adsorption of both drugs from water.","cbCaioov1A9jnBFR","https://ap.wps.com/l/cbCaioov1A9jnBFR","pdf",3217690,1,13,"English","en","# Abstract\n# Introduction\n# Keywords","[{\"question\":\"What nanocarriers are engineered for curcumin and paclitaxel delivery in this study?\",\"answer\":\"The work combines MXenes (transition metal carbides/nitrides) with a copper(II) benzene-1,3,5-tricarboxylate metal–organic framework (Cu-BTC) to form surface-modified nanocarriers for loading and delivering curcumin and paclitaxel to cancer cells.\"},{\"question\":\"How does surface termination affect drug adsorption and co-loading?\",\"answer\":\"The study compares bare and oxygen-terminated surfaces to evaluate how termination changes the adsorption efficiency of PTX and CUR and how the two drugs co-load within the Cu-BTC/MXene-based adsorbents.\"},{\"question\":\"What do the interaction energy results indicate about drug–adsorbent behavior?\",\"answer\":\"The strongest interaction energy is reported for curcumin adsorption on the MXNNO-Cu-BTC adsorbent, while PTX interaction energy in the MXNO-Cu-BTC/PTX\\u0026CUR system is lowest due to structural compatibility effects. Interaction energy between PTX and water decreases from the initial simulation to equilibrium, supporting overall adsorption performance for both drugs.\"}]",1779570094,33,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"engineering-of-surface-modified-cubtc-mxene-nanocarrier-for-adsorption-and-co-loading-of-curcuminpaclitaxel-from-aqueous-solutions-for-synergistic-multi-therapy-of-cancer","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/engineering-of-surface-modified-cubtc-mxene-nanocarrier-for-adsorption-and-co-loading-of-curcuminpaclitaxel-from-aqueous-solutions-for-synergistic-multi-therapy-of-cancer/31481/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-23",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What nanocarriers are engineered for curcumin and paclitaxel delivery in this study?","Question",{"text":73,"@type":74},"The work combines MXenes (transition metal carbides/nitrides) with a copper(II) benzene-1,3,5-tricarboxylate metal–organic framework (Cu-BTC) to form surface-modified nanocarriers for loading and delivering curcumin and paclitaxel to cancer cells.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does surface termination affect drug adsorption and co-loading?",{"text":78,"@type":74},"The study compares bare and oxygen-terminated surfaces to evaluate how termination changes the adsorption efficiency of PTX and CUR and how the two drugs co-load within the Cu-BTC/MXene-based adsorbents.",{"name":80,"@type":71,"acceptedAnswer":81},"What do the interaction energy results indicate about drug–adsorbent behavior?",{"text":82,"@type":74},"The strongest interaction energy is reported for curcumin adsorption on the MXNNO-Cu-BTC adsorbent, while PTX interaction energy in the MXNO-Cu-BTC/PTX&CUR system is lowest due to structural compatibility effects. Interaction energy between PTX and water decreases from the initial simulation to equilibrium, supporting overall adsorption performance for both drugs.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]