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Outcomes included technical success, complications, histopathology, and local recurrence during follow-up. En bloc resection reached 99.3% with R0 in 93.9%. Complications occurred in 3.4% intra-procedurally and 4.7% post-procedurally, managed conservatively, with rare recurrence.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/endoscopic-submucosal-dissection-in-gastrointestinal-lesions-clinical-outcomes-from-a-single-center/356573/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/endoscopic-submucosal-dissection-in-gastrointestinal-lesions-clinical-outcomes-from-a-single-center/356573.png","ImageObject",300,407,{"name":42,"@type":43},"\tCallum ","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study objective regarding ESD in Turkiye?","Question",{"text":63,"@type":64},"To retrospectively analyze clinical parameters including technical success, complication rates, histopathological findings, and local recurrence after ESD performed at a single center in Turkiye.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What were the main effectiveness outcomes reported?",{"text":68,"@type":64},"En bloc resection was achieved in 99.3% of cases, and R0 resection was reported in 93.9%.",{"name":70,"@type":61,"acceptedAnswer":71},"How often did complications occur and how were they managed?",{"text":72,"@type":64},"Intra-procedural complications occurred in 3.4% (mainly bleeding) and post-procedural complications in 4.7% (postESD coagulation syndrome or microperforation). 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Despite its widespread use in Eastern Asia, clinical data from Turkiye remain limited. In this study, we aimed to retrospectively analyze clinical parameters such as technical success, complication rates, histopathological findings and local recurrence rates observed during follow-up in ESD procedures performed at our center.  \nMETHODS: We retrospectively analyzed 147 patients who underwent ESD or hybrid ESD at a tertiary center between January 2020 and January 2025. Demographic characteristics, lesion features, procedural outcomes, complications, and followup results were evaluated.  \nRESULTS: En bloc resection was achieved in 99.3% of cases, with R0 resection in 93.9% . Invasive adenocarcinoma was detected in 7 patients; 3 patients with invasive adenocarcinoma and 1 patient with incomplete resection were referred for surgery. Intra-procedural complications (mainly bleeding) occurred in 3.4%, while post-procedural complications (postESD coagulation syndrome or microperforation) occurred in 4.7% . All complications were managed conservatively, and none required surgery. Median hospital stay was 1 day. Recurrence was rare and successfully managed either endoscopically or surgically.  \nCONCLUSION: ESD is a safe and effective treatment for superficial gastrointestinal neoplasms in appropriately selected patients when performed by an experienced team. High technical success and low complication rates can be achieved inexperienced centers. Future prospective, multicenter studies are warranted to establish standardized ESD practice in Turkiye.  \nKeywords: En bloc resection; endoscopic submucosal dissection; endoscopy; superficial gastrointestinal neoplasms; Turkiye.  \nCite this article as: Aykut H, Pala E, Sayar S, Ozturk O, Kahraman R, Ozdil K. Endoscopic submucosal dissection in gastrointestinal lesions: Clinical outcomes from a single center. North Clin Istanb 2026;13(1):19–27.  \nEndoscopic  \nimportant plastic lesions  \ntreatment methods are becoming more in the management of superficial neoin the gastrointestinal tract [1]. Among  \nthese approaches, Endoscopic Submucosal Dissection (ESD) stands out for enabling en bloc resection of earlystage malignancies, particularly in the stomach, esoph-  \nReceived: November 17, 2025 Accepted: December 22, 2025 Online: February 11, 2026  \nCorrespondence: Huseyin AYKUT, MD. Umraniye Egitim ve Arastirma Hastanesi, Saglik Bilimleri Universitesi, Gastroenteroloji Klinigi, Istanbul, Turkiye.  \nTel: +90 505 631 09 18 e-mail: [huseyin.ayk@gmail.com](huseyin.ayk@gmail.com)  \nIstanbul Provincial Directorate of Health-Available online [at www.northclinist.com](at www.northclinist.com)  \nagus, and colorectal regions, optimizing histopathological staging, and offering potentially curative treatment [2–4]. Initially developed in Japan for the treatment of early gastric c","cbCaida5h9nbld8a","https://ap.wps.com/l/cbCaida5h9nbld8a","pdf",248298,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Keywords\n# Introduction\n## Rationale for ESD\n## Comparison with EMR\n## Factors affecting outcomes","[{\"question\":\"What was the study objective regarding ESD in Turkiye?\",\"answer\":\"To retrospectively analyze clinical parameters including technical success, complication rates, histopathological findings, and local recurrence after ESD performed at a single center in Turkiye.\"},{\"question\":\"What were the main effectiveness outcomes reported?\",\"answer\":\"En bloc resection was achieved in 99.3% of cases, and R0 resection was reported in 93.9%.\"},{\"question\":\"How often did complications occur and how were they managed?\",\"answer\":\"Intra-procedural complications occurred in 3.4% (mainly bleeding) and post-procedural complications in 4.7% (postESD coagulation syndrome or microperforation). All were managed conservatively, and none required surgery.\"}]","Endoscopic submucosal dissection in gastrointestinal lesions - Clinical outcomes from a single center | PDF",1790126019,23]