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Hybrid ESD shortened procedure time without compromising en bloc, R0 resection, perforation, delayed bleeding, or recurrence during follow-up.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/endoscopic-submucosal-dissection-and-hybrid-endoscopic-submucosal-dissection-for-stage-1-rectal-neuroendocrine-tumors/406276/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/endoscopic-submucosal-dissection-and-hybrid-endoscopic-submucosal-dissection-for-stage-1-rectal-neuroendocrine-tumors/406276.png","ImageObject",300,407,{"name":42,"@type":43},"Melati","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the goal of this study comparing ESD and hybrid ESD?","Question",{"text":63,"@type":64},"To examine the results of endoscopic submucosal dissection (ESD) and hybrid ESD for stage 1 rectal neuroendocrine tumors (NETs).","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How many patients and lesions were included, and how were treatments allocated?",{"text":68,"@type":64},"Seventy-nine patients with 84 lesions were reviewed retrospectively; 58 patients received ESD and 21 received hybrid ESD.",{"name":70,"@type":61,"acceptedAnswer":71},"Did hybrid ESD improve procedure duration and were efficacy and safety similar?",{"text":72,"@type":64},"Hybrid ESD had a shorter median procedure duration (32.00 minutes vs 46.00 minutes, P \u003C 0.001). En bloc and R0 resection rates, perforation, delayed bleeding, and recurrence were comparable with no recurrence observed in either group after median follow-up.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},406276,1790667860,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":113,"preview_page_count":4},962085570644,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2025 December 24; 16(12): 112871  \nDOI: 10.5306/wjco.v16.i12.112871 ISSN 2218-4333 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nEndoscopic submucosal dissection and hybrid endoscopic submucosal dissection for stage 1 rectal neuroendocrine tumors  \nXue-Yan Qiao, Xiu-Jiao Shen, Yan-Hua Lv, Ruo-Bing Chen, Jun Weng, Guo-Liang Xu, Ge Wen, Kun-Hao Bai  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade C  \nNovelty: Grade A, Grade C  \nCreativity or Innovation: Grade B, Grade C  \nScientific Significance: Grade B, Grade C  \nP-Reviewer: Fuentes-Valenzuela E, MD, Academic Fellow, Spain; Toyoshima O, MD, PhD, Japan  \nReceived: August 8, 2025  \nRevised: September 14, 2025  \nAccepted: November 13, 2025  \nPublished online: December 24, 2025  \nProcessing time: 137 Days and 15.4 Hours  \nXue-Yan Qiao, Ge Wen, Department of Medical Imaging, Nanfang Hospital, Southern Medical University Nanfang Hospital, Guangzhou 510515, Guangdong Province, China  \nXue-Yan Qiao, Department of Ultrasound, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China  \nXiu-Jiao Shen, Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China  \nYan-Hua Lv, Ruo-Bing Chen, Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China  \nJun Weng, Guo-Liang Xu, Kun-Hao Bai, Department of Endoscopy, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China  \nKun-Hao Bai, Department of Epidemiology, School of Public Health, Sun Yat-sen University,  \nGuangzhou 510060, Guangdong Province, China Co-first authors: Xue-Yan Qiao and Xiu-Jiao Shen.  \nCo-corresponding authors: Ge Wen and Kun-Hao Bai.  \nCorresponding author: Kun-Hao Bai, MD, Department of Endoscopy, Sun Yat-sen University Cancer Center, No. 651 Dongfengdong Street, Yuexiu District, Guangzhou 510060, Guangdong Province, [China.](China. baikh@sysucc.org.cn)[ baikh@sysucc.org.cn](China. baikh@sysucc.org.cn)  \nAbstract  \nBACKGROUND  \nThe technical complexity and potential for complications associated with endoscopic submucosal dissection (ESD) pose limitations on the widespread use of this procedure for stage 1 rectal neuroendocrine tumors (NETs), despite its high success rate in achieving complete resection (R0) .  \nAIM  \nTo examine the results of ESD and hybrid ESD, a simpler adaptation of the ESD technique, for stage 1 rectal NETs.  \nMETHODS  \nSeventy-nine patients with 84 lesions of clinical stage 1 rectal NETs who received  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 24, 2025  Volume 16  Issue 12   \nQiao XY et al. ESD and hybrid ESD for rectal NETs  \ntreatment at Sun Yat-sen University Cancer Center from January 2010 to June 2021 were reviewed retrospectively.  \nRESULTS  \nSixty-one lesions in 58 patients were treated with ESD, while 23 in 21 patients were treated with hybrid ESD. The 84 rectal NETs had a median diameter of 8 (5) mm (range, 3-20 mm), with the median lesion size 8 (5) mm for ESD and 8 (4) mm for hybrid ESD (P = 0.359) . For ESD, the median duration of procedure was 46.00 (14.00) minutes, while for hybrid ESD, it was 32.00 (15.00) minutes (P \u003C 0.001) . Both the ESD and hybrid ESD groups had identical rates of en bloc resection (100.00% vs 100.00%, P = 1.000), R0 resection (86.89% vs 86.96%, P = 1.000), perforation (1.64% vs 0.00%, P = 1.000), and delayed bleeding (1.64% vs 4.35%, P = 0.475) . After a median of 27.50 (30.00) months of observation, neither group had recurrence.  \nCONCLUSION  \nFor endoscopic excision of stage 1 rectal NETs, both ESD and hybrid ESD","cbCaitaQsgusUKlN","https://ap.wps.com/l/cbCaitaQsgusUKlN","pdf",512143,12,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the goal of this study comparing ESD and hybrid ESD?\",\"answer\":\"To examine the results of endoscopic submucosal dissection (ESD) and hybrid ESD for stage 1 rectal neuroendocrine tumors (NETs).\"},{\"question\":\"How many patients and lesions were included, and how were treatments allocated?\",\"answer\":\"Seventy-nine patients with 84 lesions were reviewed retrospectively; 58 patients received ESD and 21 received hybrid ESD.\"},{\"question\":\"Did hybrid ESD improve procedure duration and were efficacy and safety similar?\",\"answer\":\"Hybrid ESD had a shorter median procedure duration (32.00 minutes vs 46.00 minutes, P \\u003c 0.001). En bloc and R0 resection rates, perforation, delayed bleeding, and recurrence were comparable with no recurrence observed in either group after median follow-up.\"}]","Endoscopic submucosal dissection and hybrid endoscopic submucosal dissection for stage 1 rectal neuroendocrine tumors | PDF",1790564568]