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A single-center retrospective review used a prospectively maintained database to identify lesions diagnosed as local residual/recurrent cancer and treated with endoscopic resection between 2012 and 2019. Associations of endoscopic R0 resection with conventional endoscopy findings and endoscopic ultrasonography were evaluated across 98 lesions. Results show higher R0 rates for flat lesions and suggest interrupted fifth-layer findings on EUS as favorable candidates.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endoscopic-resection-for-local-residual-or-recurrent-cancer-after-definitive-chemoradiotherapy-or-radiotherapy-for-esophageal-squamous-cell-carcinoma/382524/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/endoscopic-resection-for-local-residual-or-recurrent-cancer-after-definitive-chemoradiotherapy-or-radiotherapy-for-esophageal-squamous-cell-carcinoma/382524.png","ImageObject",300,407,{"name":92,"@type":93},"Jake","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address after chemoradiotherapy or radiotherapy for ESCC?","Question",{"text":112,"@type":113},"Local residual or recurrent cancer remains a major problem after definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma, and complete endoscopic removal is difficult to guarantee.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What was the study design and study period?",{"text":117,"@type":113},"The research used a single-center, retrospective design and identified eligible lesions treated by endoscopic resection between January 2012 and December 2019.",{"name":119,"@type":110,"acceptedAnswer":120},"Which lesion characteristics were associated with better endoscopic R0 resection?",{"text":121,"@type":113},"Endoscopic R0 resection was higher for flat lesions, and for non-flat lesions, R0 outcomes were achieved more often when the fifth layer on EUS was uninterrupted.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382524,1790709706,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nEndoscopic resection for local residual or recurrent cancer  \nafter definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma  \nYasuhiro Tani1, Ryu Ishihara1*, Noriko Matsuura1,2, Yuki Okubo1, Yushi Kawakami1, Hirohisa Sakurai1, Takahiko Nakamura1, Katsunori Matsueda1, Muneaki Miyake1, Satoki Shichijo1, Akira Maekawa1, Takashi Kanesaka1, Sachiko Yamamoto1, Yoji Takeuchi1, Koji Higashino1, Noriya Uedo1 & Tomoki Michida1  \nChemoradiotherapy (CRT) and radiotherapy (RT) are treatment options for esophageal squamous cell carcinoma (ESCC), but local residual/recurrent cancer after CRT/RT is a major problem. Endoscopic resection (ER) is an effective treatment option for local residual/recurrent cancer. To ensure the efficacy of ER, complete removal of endoscopically visible lesions with cancer-free vertical margins is desired. This study aimed to identify the endoscopic parameters associated with the complete endoscopic removal of local residual/recurrent cancer. In this single-center, retrospective study, we used a prospectively maintained database to identify esophageal lesions that were diagnosed as local residual/recurrent cancer after CRT/RT and treated by ER between January 2012 and December  \n2019. We evaluated the associations of endoscopic R0 resection with findings on conventional endoscopy and endoscopic ultrasonography (EUS) . In total, 98 lesions (83 cases) were identified from our database. The rate ofendoscopic R0 resection was higher for flat lesions (100% versus 77%, P = 0.00014). EUS was performed for 24 non-flat lesions, and endoscopic R0 resection was achieved for 94% of lesions with an uninterrupted fifth layer. Flat lesions on conventional endoscopy and lesions with an uninterrupted fifth layer on EUS are good candidates for ER.  \nEsophageal cancer is the seventh most common cancer and sixth most common cause of cancer-related mortality worldwide1, and squamous cell carcinoma is the predominant type of esophageal cancer in Asia2. Chemoradiotherapy (CRT) is a treatment option for esophageal squamous cell carcinoma (ESCC), and radiotherapy (RT) is applied for patients who are not suitable for CRT, such as elderly patients and patients with complications. Although CRT/RT can preserve the esophagus and is expected to achieve a complete response, local residual/ recurrent cancer after CRT/RT remains a major problem3. Although esophagectomy is a promising treatment for local residual/recurrent cancer, it is associated with high mortality and morbidity rates4,5. Endoscopic resection (ER) is an alternative to esophagectomy that is minimally invasive and effective if complete resection of local residual/recurrent cancer is achieved6,7.  \nThe major limitation of ER is difficulty in achieving en bloc R0 resection. Low R0 resection rates have been reported for ER of local residual/recurrent cancer because of its technical difficulty7,8. Even if pathological examination of the resected specimen reveals a positive horizontal margin, the outcome after ER is usually favorable if the endoscopically visible lesion is removed9. However, the outcome after ER with pathological evidence of a positive vertical margin has not been thoroughly evaluated. To ensure the efficacy of ER, complete removal of the endoscopically visible lesion with a cancer-free vertical margin is desired.  \nTo completely remove the lesion with a cancer-free vertical margin, accurate preoperative assessment of the cancer invasion depth is essential. However, this is sometimes difficult for local residual/recurrent cancer,  \n1Department of Gastrointestinal Oncology, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka 541-8567, Japan. 2Division of Research and Development for Minimally Invasive Treatment, Cancer Center,  \nKeio University School of Medicine, Tokyo, Japan.* email: [ryu1486@gmail.com](ryu1486@gmail.com)  \n[www. nature.com/scient","cbCaigDsFJLeZM9x","https://ap.wps.com/l/cbCaigDsFJLeZM9x","pdf",1284022,"English","# Methods\n## Study design and patients\n## Pretreatment evaluation and treatment strategy","[{\"question\":\"What problem does the study address after chemoradiotherapy or radiotherapy for ESCC?\",\"answer\":\"Local residual or recurrent cancer remains a major problem after definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma, and complete endoscopic removal is difficult to guarantee.\"},{\"question\":\"What was the study design and study period?\",\"answer\":\"The research used a single-center, retrospective design and identified eligible lesions treated by endoscopic resection between January 2012 and December 2019.\"},{\"question\":\"Which lesion characteristics were associated with better endoscopic R0 resection?\",\"answer\":\"Endoscopic R0 resection was higher for flat lesions, and for non-flat lesions, R0 outcomes were achieved more often when the fifth layer on EUS was uninterrupted.\"}]","Endoscopic resection for local residual or recurrent cancer after definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma | PDF",1790250864]