[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-340785-105":59,"doc-detail-340785-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","endoscopic-diagnosis-of-early-gastric-cancer-and-high-risk-gastritis","Endoscopic Diagnosis of Early Gastric Cancer and High-Risk Gastritis","","Endoscopic Diagnosis of Early Gastric Cancer and High-Risk Gastritis reviews how Helicobacter pylori infection drives gastric carcinogenesis through stepwise mucosal changes, emphasizing the Correa pathway from chronic gastritis to atrophy, intestinal metaplasia, and cancer. It highlights early diagnostic strategies for primary and secondary prevention, using endoscopic risk assessment based on Kyoto classification and recognition of characteristic mucosal findings. It also discusses emerging artificial intelligence–assisted endoscopic image evaluation to enhance diagnostic performance and reduce interobserver variability.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endoscopic-diagnosis-of-early-gastric-cancer-and-high-risk-gastritis/340785/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/endoscopic-diagnosis-of-early-gastric-cancer-and-high-risk-gastritis/340785.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does H. pylori infection contribute to gastric cancer development?","Question",{"text":113,"@type":114},"H. pylori infection promotes a stepwise progression through the Correa pathway, with chronic gastritis leading to epithelial atrophy and intestinal metaplasia, eventually increasing gastric cancer risk.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why are early diagnosis and endoscopic treatment important in prevention?",{"text":118,"@type":114},"Primary prevention focuses on early identification of H. pylori gastritis and eradication of bacteria, while secondary prevention relies on early gastric cancer detection and endoscopic treatment to reduce overall mortality.",{"name":120,"@type":111,"acceptedAnswer":121},"What role do endoscopic risk scores and the Kyoto classification play?",{"text":122,"@type":114},"They support the identification of precancerous lesions and early gastric cancer by evaluating endoscopic gastric cancer risk based on the Kyoto classification of gastritis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},340785,1790079432,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","KJHUGR REVIEW  \npISSN 1738-3331 / eISSN 2671-826X [https://doi.org/10.7704/kjhugr.2024.0047](https://doi.org/10.7704/kjhugr.2024.0047) Korean J Helicobacter Up Gastrointest Res 2024;24(4):311-318  \n[https://www.helicojournal.org](https://www.helicojournal.org)  \nReceived July 15, 2024  \nAccepted August 8, 2024  \nCorresponding author  \nHidekazu Suzuki, MD, PhD, FACG, AGAF, RFF, FJGES  \nDivision of Gastroenterology and Hepatology,  \nDepartment of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan  \nE-mail: [hsuzuki@tokai.ac.jp](hsuzuki@tokai.ac.jp)  \nAvailability of Data and Material  \nData sharing not applicable to this article as no datasets were generated or analyzed during the study.  \nConflicts of Interest  \nHidekazu Suzuki, a contributing editor of the Korean Journal of Helicobacter and Upper Gastrointestinal Research, was not involved in the editorial evaluation or decision to publish this article. Hidekazu Suzuki has received research funding from Tohso Company, Ltd., Biofermin Pharmaceutical Company, Ltd., and honorarium from Astellas Pharmaceutical Company, Otsuka  \nPharmaceutical Company, Ltd., Takeda  \nPharmaceutical Company, Ltd. Other authors have no conflict of interest to declare.  \nFunding Statement  \nNone  \nAcknowledgements  \nNone  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://creativecommons.org/licenses/](https://creativecommons.org/licenses/)[ ](https://creativecommons.org/licenses/)[by-nc/4.0](by-nc/4.0)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nEndoscopic Diagnosis of Early Gastric Cancer and High-Risk Gastritis  \nHidekazu Suzuki1, Masaya Sano1, Toshihiro Nishizawa2, and Osamu Toyoshima3  \n1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan  \n2Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital, Tokyo, Japan  \n3Toyoshima Endoscopy Clinic, Tokyo, Japan  \nMany differentiated and undifferentiated gastric cancers are associated with Helicobacter pylori infection. Therefore, as a primary prevention method, the early diagnosis of H. pylori gastritis and eradication of these bacteria can prevent gastric cancer. As a secondary prevention method, the early diagnosis of gastric cancer and endoscopic treatment can also contribute to reducing overall mortality. Gastric mucosal atrophy and intestinal metaplasia are important findings in patients with H. pylori gastritis. The accurate diagnosis of other characteristic findings is also important to comprehensively assess gastric cancer risk. The identification of precancerous lesions and early gastric cancer by evaluating endoscopic gastric cancer risk scores, based on the Kyoto classification of gastritis, is similarly important. Recently, endoscopic image evaluation systems equipped with artificial intelligence have been developed to complement the diagnostic abilities of individual endoscopists and reduce interobserver variability; future developmentsin this area are highly anticipated.  \nKeywords Gastric cancer; Gastritis; Helicobacter pylori; Diagnosis; Infection.  \nHELICOBACTER PYLORI AND GASTRIC CANCER  \nHelicobacter pylori is an important cause of non-cardia gastric cancer and is the most prevalent carcinogenic infectious  \nagent, worldwide, especially in East Asia.1,2 The development of intestinal-type gastric cancer has long been hypothesized to involve a stepwise transformation from normal gastric epithelium to malignancy. During this transformation, intestinal epithelial properties are acquired at an intermediate stage. This  \nCopyright © 2024 Korean College of Helicobacter and Upper Gastrointestinal Research 311  \n KJHUGR  \nstepwise progression from a normal gastric epithelium t","cbCaim4QxJKp4Mni","https://ap.wps.com/l/cbCaim4QxJKp4Mni","pdf",1198492,"English","# Endoscopic diagnosis and prevention strategy\n## Helicobacter pylori infection and the Correa pathway\n## Endoscopic risk scores and Kyoto classification\n## Artificial intelligence in endoscopic image evaluation","[{\"question\":\"How does H. pylori infection contribute to gastric cancer development?\",\"answer\":\"H. pylori infection promotes a stepwise progression through the Correa pathway, with chronic gastritis leading to epithelial atrophy and intestinal metaplasia, eventually increasing gastric cancer risk.\"},{\"question\":\"Why are early diagnosis and endoscopic treatment important in prevention?\",\"answer\":\"Primary prevention focuses on early identification of H. pylori gastritis and eradication of bacteria, while secondary prevention relies on early gastric cancer detection and endoscopic treatment to reduce overall mortality.\"},{\"question\":\"What role do endoscopic risk scores and the Kyoto classification play?\",\"answer\":\"They support the identification of precancerous lesions and early gastric cancer by evaluating endoscopic gastric cancer risk based on the Kyoto classification of gastritis.\"}]","Endoscopic Diagnosis of Early Gastric Cancer and High-Risk Gastritis | PDF",1790038887]