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This single-center retrospective study evaluated mucosal and endoscopic characteristics that may indicate risk in early gastric cancer (EGC) after eradication. Data from 133 patients with 139 EGCs were compared with 158 patients with 170 Hp-positive EGCs, and 107 non-EGC controls after eradication were analyzed. Key risks included moderate/severe gastric atrophy, corpus intestinal metaplasia, severe diffuse redness, and map-like redness, with depressed erosion independently linked to IIc-type EGC.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endoscopic-characteristics-and-high-risk-background-mucosa-factors-of-early-gastric-cancer-after-helicobacter-pylori-eradication-single-center-retrospective-study/382947/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/endoscopic-characteristics-and-high-risk-background-mucosa-factors-of-early-gastric-cancer-after-helicobacter-pylori-eradication-single-center-retrospective-study/382947.png","ImageObject",300,407,{"name":92,"@type":93},"Mabel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main purpose of the study on EGC after Helicobacter pylori eradication?","Question",{"text":113,"@type":114},"To explore endoscopic characteristics and identify mucosal factors associated with high risk for early gastric cancer after successful Helicobacter pylori eradication.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients grouped in the study?",{"text":118,"@type":114},"The study compared EGC after eradication (139 EGCs in 133 patients) with Hp-positive EGC (170 EGCs in 158 patients) and included a Hp-eradication non-EGC group (107 patients without EGC after eradication).",{"name":120,"@type":111,"acceptedAnswer":121},"Which endoscopic and mucosal factors were associated with higher EGC risk after eradication?",{"text":122,"@type":114},"Lower stomach location, yellowish color, and smaller size were endoscopic features linked to EGC after eradication. Risk background mucosal factors included moderate/severe gastric atrophy, intestinal metaplasia in the corpus, severe diffuse redness, and map-like redness.",{"name":124,"@type":111,"acceptedAnswer":125},"What findings relate to IIc-type EGC after eradication?",{"text":126,"@type":114},"Depressed erosion was found as an independent risk factor for IIc-type EGC after Helicobacter pylori eradication, and EGC after eradication with IIc-type should be cautioned when depressed erosion is present.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},382947,1790376413,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":144,"language":145,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":146,"faqs":147,"seo_title":148,"seo_description":67,"update_tm":149,"read_time":150},7971474920318,"https://ap-avatar.wpscdn.com/avatar/74000ee537e6b0ca360?x-image-process=image/resize,m_fixed,w_180,h_180&k=1788430171632181674","TYPE Original Research PUBLISHED 02 October 2023 DOI 10.3389/fonc.2023.1272187  \nOPEN ACCESS  \nEDITED BY Qun Zhang,  \nNanjing Medical University, China  \nREVIEWED BY Zhuang Kun,  \nXi’an Central Hospital, China Hui Li,  \nThe Second Affiliated Hospital of Harbin Medical University, China  \n*CORRESPONDENCE Xiaoyan Yin  \n[yxy4503@163.com](yxy4503@163.com)  \nRECEIVED 03 August 2023  \nACCEPTED 30 August 2023  \nPUBLISHED 02 October 2023  \nCITATION  \nWei Y, Min C, Zhao C, Li Y, Wang X, Jing X, Yu Y, Li X and Yin X (2023) Endoscopic characteristics and high-risk background mucosa factors of early gastric cancer after helicobacter pylori eradication: a singlecenter retrospective study.  \nFront. Oncol. 13:1272187 .  \ndoi: 10.3389/fonc.2023.1272187  \nCOPYRIGHT  \n© 2023 Wei, Min, Zhao, Li, Wang, Jing, Yu, Li and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEndoscopic characteristics and high-risk background mucosa factors of early gastric cancer after helicobacter pylori eradication: a single-center retrospective study  \nYali Wei 1, Congcong Min 1, Chongguang Zhao 2, Yubei Li 1, Xiaowei Wang 1, Xue Jing 1, Yanan Yu 1, Xiaoyu Li 1 and Xiaoyan Yin 1*  \n1 Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, 2 Department of Clinical Medicine, Qingdao University Medical College, Qingdao, Shandong, China  \nPurpose: Gastric cancer still develops after successful Helicobacter pylori(Hp) eradication. In this study, we aimed to explore the characteristics and risks of mucosal factors.  \nMethods: A total of 139 early gastric cancers (EGC) diagnosed in 133 patients after successful eradication from January 2016 to December 2021 were retrospectively included in the Hp-eradication EGC group and 170 EGCs diagnosed in 158 patients were included in the Hp-positive EGC group. We analyzed the clinical, pathological, and endoscopic characteristics between the two groups to identify the features of EGC after Hp eradication. Another 107 patients with no EGC after Hp eradication were enrolled in a Hp-eradication non-EGC group. The background mucosal factors between the Hp-eradication EGC group and the Hp-eradication non-EGC group were compared to analyze the high-risk background mucosal factors of EGC after eradication. In addition, we divided the EGC group after Hp eradication into IIc type and non-IIc type according to endoscopic gross classification to assess the high-risk background factors of IIc-type EGC after Hp eradication.  \nResults: The endoscopic features of EGC after Hp eradication included location in the lower part of the stomach (p=0.001), yellowish color (p= 0.031), and smaller size (p=0 . 001) . The moderate/severe gastric atrophy (GA), intestinal metaplasia (IM) in the corpus, severe diffuse redness, and map-like redness were risk factors for EGC after eradication (p=0 . 001, p=0 . 001, p=0 . 001, and p= 0 . 005, respectively) . The Kyoto classification total score in the EGC group was higher than the non-EGC group (4 vs.3 p\u003C0 . 001) . A multivariate analysis revealed that depressed erosion (OR=3 . 42, 95% CI 1 .35-8. 65, p= 0 . 009) was an independent risk factor for IIc-type EGC after Hp eradication.  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nConclusion: EGC after eradication are smaller and yellowish lesions located in the lower part of the stomach. The risk background mucosal factors include moderate/severe GA, IM in the corpus, severe diffuse redness, and map-like redness. The Kyoto classification total score of 4 or more after successful eradication treatment might in","cbCaipB5BS4wXYFi","https://ap.wps.com/l/cbCaipB5BS4wXYFi","pdf",2224622,13,"English","# Purpose\n# Methods\n# Results\n## Endoscopic features after eradication\n## Background mucosal risk factors\n# Conclusion","[{\"question\":\"What was the main purpose of the study on EGC after Helicobacter pylori eradication?\",\"answer\":\"To explore endoscopic characteristics and identify mucosal factors associated with high risk for early gastric cancer after successful Helicobacter pylori eradication.\"},{\"question\":\"How were patients grouped in the study?\",\"answer\":\"The study compared EGC after eradication (139 EGCs in 133 patients) with Hp-positive EGC (170 EGCs in 158 patients) and included a Hp-eradication non-EGC group (107 patients without EGC after eradication).\"},{\"question\":\"Which endoscopic and mucosal factors were associated with higher EGC risk after eradication?\",\"answer\":\"Lower stomach location, yellowish color, and smaller size were endoscopic features linked to EGC after eradication. Risk background mucosal factors included moderate/severe gastric atrophy, intestinal metaplasia in the corpus, severe diffuse redness, and map-like redness.\"},{\"question\":\"What findings relate to IIc-type EGC after eradication?\",\"answer\":\"Depressed erosion was found as an independent risk factor for IIc-type EGC after Helicobacter pylori eradication, and EGC after eradication with IIc-type should be cautioned when depressed erosion is present.\"}]","Endoscopic characteristics and high-risk background mucosa factors of early gastric cancer after helicobacter pylori eradication - single-center retrospective study | PDF",1790253172,33]