[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382145-105":59,"doc-detail-382145-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","endoplasmic-reticulum-stress-in-renal-cell-carcinoma-review","Endoplasmic Reticulum Stress in Renal Cell Carcinoma - Review","","The endoplasmic reticulum is essential for protein production, metabolic homeostasis, and cell signaling. Endoplasmic reticulum stress emerges when cellular damage reduces the organelle’s ability to function normally, triggering unfolded protein response signaling that can reshape cell fate. In renal cells, these pathways help resolve injury or induce cell death, making pathway modulation a proposed cancer therapy. However, renal cancer cells repurpose these stress signals to support survival via metabolic rewiring, oxidative stress responses, autophagy, and apoptosis inhibition, with a stress threshold shifting outcomes toward pro-apoptosis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endoplasmic-reticulum-stress-in-renal-cell-carcinoma-review/382145/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/endoplasmic-reticulum-stress-in-renal-cell-carcinoma-review/382145.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is endoplasmic reticulum (ER) stress and how is it linked to cell fate?","Question",{"text":113,"@type":114},"ER stress occurs when cell damage reduces the endoplasmic reticulum’s capacity to perform its normal functions. 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Endoplasmic Reticulum Stress in Renal Cell Carcinoma. Int. J. Mol. Sci. 2023, 24, 4914. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms24054914  \nAcademic Editor: Giuseppe Lucarelli  \nReceived: 18 January 2023  \nRevised: 22 February 2023  \nAccepted: 23 February 2023  \nPublished: 3 March 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland  \n* Correspondence: michelangelo.foti@unige.ch (M.F.); [monika.gjorgjieva@unige.ch](monika.gjorgjieva@unige.ch) (M.G.)† These authors contributed equally to this work.  \nAbstract: The endoplasmic reticulum is an organelle exerting crucial functions in protein production, metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and the capacity of this organelle to perform its normal functions is reduced. Subsequently, specific signaling cascades, together forming the so-called unfolded protein response, are activated and deeply impact cell fate. In normal renal cells, these molecular pathways strive to either resolve cell injury or activate cell death, depending on the extent of cell damage. Therefore, the activation of the endoplasmic reticulum stress pathway was suggested as an interesting therapeutic strategy for pathologies such as cancer. However, renal cancer cells are known to hijack these stress mechanismsand exploit them to their advantage in order to promote their survival through rewiring of their metabolism, activation of oxidative stress responses, autophagy, inhibition of apoptosis and senescence. Recent data strongly suggest that a certain threshold of endoplasmic reticulum stress activation needs to be attained in cancer cells in order to shift endoplasmic reticulum stress responses from a pro-survival to a pro-apoptotic outcome. Several endoplasmic reticulum stress pharmacological modulators of interest for therapeutic purposes are already available, but only a handful were tested in the case of renal carcinoma, and their effects in an in vivo setting remain poorly known. This review discusses the relevance of endoplasmic reticulum stress activation or suppression in renal cancer cell progression and the therapeutic potential of targeting this cellular process for this cancer.  \nKeywords: renal cell carcinoma (RCC); chronic kidney disease (CKD); endoplasmic reticulum (ER) stress  \n1. The Kidney and Renal Cell Carcinoma  \nThe kidney carries out key physiological functions in the organism including blood filtration and pressure regulation, drug metabolism and glycemia control, as well as excretion of toxic metabolites. Tubular cells are the most abundant cell type of the kidney, and are major actors in the filtration/reabsorption processes and glycaemia control exerted by the kidney [1–3] . These cells are thus highly metabolically active and have high energetic requirements, usually satisfied by lipid 􀀌-oxidation but also through glycolysis in pathological conditions [3,4] . This variety of functions renders tubular cells particularly susceptible to stress-induced cell injury associated with drugs/metabolites toxicity and ischemic episodes, which with chronicity can lead to the development of renal cancer.  \n1.1. Renal Cell Carcinoma Epidemiology and Mutational Profiles  \nRenal cell carcinoma (RCC) mostly arises from tubular ce","cbCaivk6l3klmWiz","https://ap.wps.com/l/cbCaivk6l3klmWiz","pdf",3291634,26,"English","# The Kidney and Renal Cell Carcinoma\n## Renal Cell Carcinoma Epidemiology and Mutational Profiles","[{\"question\":\"What is endoplasmic reticulum (ER) stress and how is it linked to cell fate?\",\"answer\":\"ER stress occurs when cell damage reduces the endoplasmic reticulum’s capacity to perform its normal functions. It activates signaling cascades that form the unfolded protein response, which can lead to injury resolution or cell death depending on damage extent.\"},{\"question\":\"How do renal cancer cells use ER stress pathways to promote survival?\",\"answer\":\"Renal cancer cells hijack stress mechanisms to gain advantage, supporting survival through metabolic rewiring, activation of oxidative stress responses, stimulation of autophagy, and inhibition of apoptosis and senescence.\"},{\"question\":\"Why might ER stress activation need to reach a specific threshold in cancer cells?\",\"answer\":\"The review suggests that cancer cells must attain a certain threshold of ER stress activation to shift responses from a pro-survival outcome toward a pro-apoptotic one.\"}]","Endoplasmic Reticulum Stress in Renal Cell Carcinoma - Review | PDF",1790249291,66]