[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-366080-en":3,"detail-sidebar-cat-0-en-105":31,"doc-seo-366080-105":82},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":28,"seo_description":14,"update_tm":29,"read_time":30},366080,962085564807,"Rizky","https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8",7,"Healthcare","Endometrioid adenofibroma of ovary - a literature review","Ovarian neoplasms are the third most common gynecological cancer and often carry a worse prognosis than breast cancer. Endometrioid borderline ovarian tumors show glandular patterns with mild to moderate atypia and no stromal invasion. A comprehensive PubMed review was conducted to identify risk factors and etiological determinants for ovarian endometrioid adenofibroma. A 27-year-old patient with a 6 cm left ovarian mass underwent successful laparoscopic adnexa removal and was discharged without complications. The review emphasizes diagnostic challenges, the role of immunohistochemistry, and fertility-preserving surgical strategy for early-stage non-invasive disease, noting potential links with fertility treatments.","REVIEW AND CASE REPORT  \nR J M E  \nRomanian Journal of Morphology & Embryology  \n[http://www.rjme.ro/](http://www.rjme.ro/)  \nEndometrioid adenofibroma of ovary – a literature review  \nLAURENŢIU AUGUSTUS BARBU1,2), LIVIU VASILE1,3), TIBERIU ŞTEFĂNIŢĂ ŢENEA-COJAN1,2), GABRIEL FLORIN RĂZVAN MOGOŞ1,2), VALERIU ŞURLIN1,3), IONICĂ DANIEL VÎLCEA1,3),  \nLILIANA CERCELARU4,5), STELIAN ŞTEFĂNIŢĂ MOGOANTĂ1,3), NICOLAE-DRAGOŞ MĂRGĂRITESCU1,3)  \n1) Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania  \n2) Department of Surgery, Railway Clinical Hospital, Craiova, Romania  \n3) Department of Surgery, Emergency County Hospital, Craiova, Romania  \n4) Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania  \n5) Department of Pathology, Emergency County Hospital, Craiova, Romania  \nAbstract  \nBackground/Objectives: Ovarian neoplasms are the third most common gynecological cancer and carry a poorer prognosis than breast cancer. Endometrioid borderline ovarian tumors (EBOTs) are intermediate epithelial lesions, histologically showing glandular patterns with mild to moderate atypia and no stromal invasion. Study selection for review: A comprehensive electronic search was conducted on PubMed to identify risk factors and etiological determinants associated with ovarian endometrioid adenofibroma (EA) . Case presentation: A 27-year-old woman with a left ovarian cyst underwent a laparoscopic procedure to remove the adnexa after imaging showed a 6 cm mass. Surgery was successful, and she was discharged without complications. Conclusions: This study highlights the diagnostic challenges of EBOTs, the essential role of immunohistochemistry, and the need for careful surgical and fertility-preserving strategies. It also draws attention to possible risks linked to fertility treatments. Fertility preservation is crucial in young patients, favoring uterine and ovarian conservation. In early-stage, small, non-invasive tumors, laparoscopy is the preferred approach. EAs are uncommon benign ovarian tumors, accounting for approximately 1% of epithelial neoplasms, and are predominantly unilateral.  \nKeywords: borderline ovarian tumors, endometrioid adenofibroma of ovary, laparoscopic ovarian resection, conservative surgery.  \n􀀕 Introduction  \nOvarian neoplasms represent the third most prevalent gynecological malignancy globally, following cervical and endometrial cancers, and are associated with the poorest prognosis among female cancers. Epidemiological projections suggest a marked increase in ovarian cancer-related mortality by 2040 [1, 2]. This unfavorable outlook is largely attributed to the frequent diagnosis at advanced stages, resulting from asymptomatic progression or the late onset of nonspecific symptoms. Furthermore, the absence of an effective population-wide screening strategy continues to hinder early detection and improved survival rates [1]. Histologically, ovarian tumors encompass a wide spectrum, with epithelial neoplasms being the most common, displaying significant heterogeneity in differentiation and biological behavior.  \nEpidemiological data indicate that ovarian cancer incidence is highest among non-Hispanic white women, with 12 cases per 100 000 population. Hispanic women have an incidence rate of 10.3 per 100 000, whereas nonHispanic Black women and Asian women exhibit lower rates of 9.4 and 9.2 per 100 000, respectively [3] . These disparities suggest the potential involvement of genetic, environmental, and socioeconomic factors in disease prevalence, warranting further investigation into populationspecific risk profiles and access to early detection strategies.  \nIn 2022, there were 324 603 newly diagnosed cases  \nof ovarian neoplasms worldwide [4] . The World Health Organization (WHO) reports over 250 000 ovarian cancerrelated deaths annually [5] . Ovarian tumors can originate from epithelial, stromal, or germ cell tissues, with recent studies suggesting that the fallopian tube epithelium","cbCaiecaVVs1Xfya","https://ap.wps.com/l/cbCaiecaVVs1Xfya","pdf",1943902,14,1,11,"English","en",105,"# Abstract\n## Background/Objectives\n## Study selection for review\n## Case presentation\n## Conclusions\n# Introduction\n## Epidemiology and prognosis\n## Incidence disparities\n## Global burden\n## Origins and symptoms","[{\"question\":\"What are the key histological features of endometrioid borderline ovarian tumors (EBOTs)?\",\"answer\":\"EBOTs are intermediate epithelial lesions with glandular patterns showing mild to moderate atypia and no stromal invasion.\"},{\"question\":\"How was the case of endometrioid adenofibroma managed in the reported patient?\",\"answer\":\"A 27-year-old woman with a left ovarian cyst and a 6 cm mass underwent laparoscopic adnexa removal, and she was discharged without complications.\"},{\"question\":\"Why are immunohistochemistry and fertility-preserving surgery emphasized?\",\"answer\":\"The study highlights diagnostic challenges of EBOTs and the essential role of immunohistochemistry, while stressing careful surgical approaches that preserve fertility in young patients, especially for early-stage small non-invasive tumors.\"}]","Endometrioid adenofibroma of ovary - 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