[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-26070-105":59,"doc-detail-26070-en":107},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":100,"head_meta":102,"extra_data":104,"updated_unix":106},105,"en","endocrinology-pearls","Endocrinology pearls","","This document provides pearls of wisdom regarding endocrinology, focusing on the hypothalamic-pituitary axis. It delves into the presentation of patients with pituitary disease, emphasizing the importance of hormone assays prior to imaging to avoid overdiagnosis of pituitary incidentalomas. A key clinical pearl is presented regarding treatment. The document specifically details the clinical features of prolactinoma, outlining the recommended investigations and the interpretation of prolactin levels. A significant section is dedicated to dopamine agonist therapy, including a table (18.59) that compares bromocriptine, cabergoline, and quinagolide. Each drug is described with its oral dose, advantages, and disadvantages. Bromocriptine is available for parenteral use, has a short half-life, is useful in treating infertility, and has proven long-term efficacy, but can cause ergotamine-like side-effects, requires frequent dosing leading to poor adherence, and has rare reports of fibrotic reactions. Cabergoline is long-acting, meaning missed doses are less important, and is reported to have fewer ergotamine-like side-effects. However, it has limited data on safety in pregnancy and is associated with cardiac valvular fibrosis in Parkinson's disease. Quinagolide is a non-ergot with few side-effects in patients intolerant of the other agents, but also has limited data on safety in pregnancy. A footnote clarifies that tolerance develops for side effects, and all agents, especially bromocriptine, must be introduced at a low dose and increased slowly. If several doses of bromocriptine are missed, the process must start again. Additionally, a diagram illustrates the hypothalamic-pituitary-endocrine organ axis, showing the regulation of tropic and nontropic hormones by the hypothalamus and pituitary gland, and their effects on target tissues such as ovaries/testes, adrenal gland, thyroid, mammary gland, and liver. This includes hormones like GnRH, FSH, LH, ACTH, CRH, TRH, TSH, GRH, GH, and prolactin, and their synthesized products and ultimate effects like sex hormones, cortisol, T3/T4, lactation, and IGF-1.",{"@graph":69,"@context":99},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endocrinology-pearls/26070",{"url":83,"name":65,"@type":85,"author":86,"headline":65,"publisher":89,"fileFormat":92,"description":67,"dateModified":93,"datePublished":93,"encodingFormat":92,"isAccessibleForFree":94,"interactionStatistic":95},"DigitalDocument",{"name":87,"@type":88},"Aria","Person",{"url":74,"name":90,"@type":91},"DocShare","Organization","application/pdf","2026-05-07",true,{"@type":96,"interactionType":97,"userInteractionCount":4},"InteractionCounter",{"@type":98},"ViewAction","https://schema.org",{"og:url":83,"og:type":101,"og:title":65,"og:site_name":90,"og:description":67},"article",{"robots":103,"canonical":83},"index,follow",{"doc_id":105,"site_id":62},26070,1778196093,{"code":4,"msg":5,"data":108},{"doc_id":105,"user_id":109,"nickname":87,"user_avatar":110,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":111,"file_url":112,"file_type":113,"file_size":114,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":115,"language":116,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":117,"seo_description":67,"update_tm":106,"read_time":118},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","cbCaifgfteWVRYRl","https://ap.wps.com/l/cbCaifgfteWVRYRl","pdf",4399609,72,"English","Endocrinology pearls | PDF",181]