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A genomic network connecting NR-driven tumor development and progression has been highlighted through advanced genomic technologies. Expression of a specific NR in a tumor subtype reflects a broader transcriptional machinery controlled by multiple NRs and transcription factors. NRs are also regulated by non-coding RNAs, including microRNAs and long non-coding RNAs. This review outlines reciprocal interactions between key NRs and lncRNAs across tumors, aiming to identify diagnostic biomarkers and therapeutic strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endocrine-nuclear-receptors-and-long-non-coding-rnas-reciprocal-regulation-in-cancer-review/380706/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/endocrine-nuclear-receptors-and-long-non-coding-rnas-reciprocal-regulation-in-cancer-review/380706.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main relationship discussed between nuclear receptors and long non-coding RNAs?","Question",{"text":112,"@type":113},"The review describes reciprocal regulation, where nuclear receptors can be regulated by non-coding RNAs (including microRNAs and long non-coding RNAs) and can also regulate lncRNAs. This crosstalk is linked to oncogenic processes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do nuclear receptors influence gene expression in cells?",{"text":117,"@type":113},"Nuclear receptors are ligand-activated transcription factors that interact with DNA sequences in promoter and enhancer regions of target genes. They modulate transcription through co-binding to co-factors/coregulators involved in transcription initiation.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic and diagnostic directions does the review propose?",{"text":121,"@type":113},"By outlining interactions between main NRs and long non-coding RNAs across tumor diseases, the review aims to suggest new diagnostic biomarkers and therapeutic strategies for these cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380706,1790333440,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","INTERNATIONAL JOURNAL OF ONCOLOGY 64: 7, 2024  \nEndocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review)  \nMONICA CANTILE 1* , MARGHERITA CERRONE2* , MAURIZIO DI BONITO2 , PASQUALE MOCCIA2 , MAURA TRACEY3 , GERARDO FERRARA2 and ALFREDO BUDILLON 1  \n1Scientific Directorate; 2Pathology Unit and 3Rehabilitation Medicine Unit, National Cancer Institute INT‑IRCCS Fondazione G. Pascale, I‑80131 Naples, Italy  \nReceived April 20, 2023; Accepted September 26, 2023  \nDOI: 10.3892/ijo.2023.5595  \nAbstract. Nuclear receptors (NRs) are transcriptional regula‑ tors involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR in a given cancer subtype is only one component of a larger transcriptional machinery that is controlled by multiple asso‑ ciated NRs and transcription factors. Additionally, their ability to regulate and to be regulated by molecules of non‑coding RNAs, microRNAs as well as long non‑coding RNAs, is opening new scenarios for understanding the role of NRs in cancer initiation and progression. In the present review, the authors aimed to outline the reciprocal interactions that exist between the main NRs and long non‑coding RNAs in different tumor diseases, to suggest new diagnostic biomarkers as well as therapeutic strategies for these tumors.  \nContents  \n1. Introduction  \n2. Crosstalk between estrogen receptor (ER) α and long non‑coding RNAs (lncRNAs) in cancer  \n3. Crosstalk between ERβ and lncRNAs in cancer  \nCorrespondence to: Dr Monica Cantile, Scientific Directorate, National Cancer Institute INT‑IRCCS Fondazione G. Pascale, 53 Via Mariano Semmola, I‑80131 Naples, Italy  \nE‑[mail: m.cantile@istitutotumori.na.it](mail: m.cantile@istitutotumori.na.it)[ ](mail: m.cantile@istitutotumori.na.it)*Contributed equally  \nKey words: nuclear receptors, long non‑coding RNAs, cancer progression  \n4. Crosstalk between androgen receptors and lncRNAs in cancer  \n5. Crosstalk between other nuclear receptors and lncRNAs in cancer  \n6. Conclusions  \n1. Introduction  \nNuclear receptors (NRs) are ligand‑activated transcrip‑ tion factors involved in main cellular processes including homeostasis, metabolism, growth, differentiation and development (1) . These receptors interact with specific DNA sequences in the promoter and enhancer regions of their target genes modulating their transcription by co‑binding to a series of co‑factors/coregulators belonging to transcription initiation machinery (2) . The NR superfamily can be divided into three classes based on the type of ligand: Endocrine, metabolic and orphan NRs (3) . The endocrine NR subfamily includes estrogen receptors (ERs) αlpha (ERα or ESR1) and ERβ (ERβ or ESR2), androgen receptors (AR), progesterone receptors, glucocorticoid receptors, mineralocorticoid receptors, vitamin D receptors (VDRs), retinoic acid receptors (RARs), as well as thyroid hormone receptors (THRs) (1) .  \nNumerous factors contribute to the regulation of NRs, especially the recruitment of coregulatory proteins, post‑trans‑ lational modifications and interactions with other transcription factors.  \nDysregulated NR signaling can promote a large series of pathological processes . In particular, mutation or aberrant expression of NR and/or of their coregulators may influence both the development and progression of several human diseases including cancer (4) . Moreover, epigenetic regula‑ tion, especially by activation of non‑coding RNA molecules (ncRNAs), represents an element of complexity in the modula‑ tion of NR‑dependent gene expression.  \nLong non‑codi","cbCaiidC68bC6JDI","https://ap.wps.com/l/cbCaiidC68bC6JDI","pdf",934116,14,"English","# Introduction\n# Crosstalk between estrogen receptor (ER) α and long non-coding RNAs (lncRNAs) in cancer\n# Crosstalk between ERβ and lncRNAs in cancer\n# Crosstalk between androgen receptors and lncRNAs in cancer\n# Crosstalk between other nuclear receptors and lncRNAs in cancer\n# Conclusions","[{\"question\":\"What is the main relationship discussed between nuclear receptors and long non-coding RNAs?\",\"answer\":\"The review describes reciprocal regulation, where nuclear receptors can be regulated by non-coding RNAs (including microRNAs and long non-coding RNAs) and can also regulate lncRNAs. This crosstalk is linked to oncogenic processes.\"},{\"question\":\"How do nuclear receptors influence gene expression in cells?\",\"answer\":\"Nuclear receptors are ligand-activated transcription factors that interact with DNA sequences in promoter and enhancer regions of target genes. They modulate transcription through co-binding to co-factors/coregulators involved in transcription initiation.\"},{\"question\":\"What therapeutic and diagnostic directions does the review propose?\",\"answer\":\"By outlining interactions between main NRs and long non-coding RNAs across tumor diseases, the review aims to suggest new diagnostic biomarkers and therapeutic strategies for these cancers.\"}]","Endocrine nuclear receptors and long non-coding RNAs reciprocal regulation in cancer - Review | PDF",1790241395,35]