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Data from NHANES (2003–2012) were used, with urinary BPA measured by LC–MS. Multivariable Cox proportional hazards models and constrained cubic splines assessed relationships with all-cause and cancer mortality. Among 8,035 participants followed for 7.5 years, urinary BPA showed no independent association with all-cause mortality, while cancer mortality exhibited a U-shaped pattern with a lower level (\u003C1.99 ng/mL) linked to higher cancer mortality risk.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/endocrine-disrupting-chemical-bisphenol-a-and-its-association-with-cancer-mortality-a-prospective-cohort-study-of-nhanes/331978/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/endocrine-disrupting-chemical-bisphenol-a-and-its-association-with-cancer-mortality-a-prospective-cohort-study-of-nhanes/331978.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What dataset and exposure measure were used to study BPA and mortality?","Question",{"text":113,"@type":114},"The study used NHANES data from 2003–2012. Urinary BPA was measured using liquid chromatography-mass spectrometry (LC–MS).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the relationship between urinary BPA and mortality analyzed?",{"text":118,"@type":114},"The analysis used multivariable Cox proportional hazard regressions and constrained cubic splines to assess associations with all-cause and cancer mortality, including checks for nonlinearity.",{"name":120,"@type":111,"acceptedAnswer":121},"What was the main finding regarding cancer mortality risk?",{"text":122,"@type":114},"Cancer mortality risk showed a U-shaped association with urinary BPA. 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Public Health 12:1341789.  \ndoi: 10.3389/fpubh.2024.1341789  \nCOPYRIGHT  \n© 2024 Yuan, Chen, Ding, Zhong and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEndocrine disrupting chemical Bisphenol A and its association with cancer mortality: a prospective cohort study of NHANES  \nYing Yuan, Qian Chen, Xiaorong Ding, Qin Zhong and Xiaomin Zhong *  \nDepartment of Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, China  \nIntroduction: There is evidence suggesting that Bisphenol A (BPA) is associated with increased all-cause mortality in adults. However, the specific nature of the relationship between BPA exposure and cancer mortality remains relatively unexplored.  \nMethods: The National Health and Nutrition Examination Survey (NHANES) dataset was used to recruit participants. Urinary BPA was assessed using liquid chromatography-mass spectrum (LC–MS) . Through the use of multivariable Cox proportional hazard regressions and constrained cubic splines, the relationships between urine BPA and death from all causes and cancer were investigated.  \nResults: This study has a total of 8,035 participants, and 137 died from cancers after a 7. 5-year follow-up. The median level of BPA was 2.0 g/mL. Urinary BPA levels were not independently associated with all-cause mortality. For cancer mortality, the second quartile’s multivariable-adjusted hazard ratio was 0.51 (95% confidence interval: 0.30 to 0. 86; p = 0.011) compared to the lowest quartile. The restricted cubic splines showed that the association was nonlinear (p for nonlinearity = 0.028) and the inflection point was 1.99 ng/mL.  \nConclusion: Urinary BPA exposure was U-shaped associated with the risk of cancer mortality, and a lower level of BPA less than 1.99 ng/mL was associated with a higher risk of cancer mortality.  \nKEYWORDS  \nenvironmental phenols, Bisphenol A, cancer mortality, all-cause mortality, NHANES  \nIntroduction  \nBisphenol A (BPA) is a kind of environmental phenols utilized in baby bottles, food containers, and dentistry ( 1). The exposure of humans to BPA is pervasive, originating from various sources such as consumer products, food, water, and dust (2) . National biological monitoring data in the United States reveals that BPA is detectable in more than 90% of urine samples in the general population (3). Currently, 12 states have enforced regulations to restrict the use of BPA in the United States. While BPA is known to undergo rapid metabolism and is primarily eliminated through urine, its cumulative exposure in everyday items could lead to  \nFrontiers in Public Health 01 [frontiersin.org](frontiersin.org)  \nconcerns regarding potential long-term health consequences (4) . The potential pathways underlying BPA-induced adverse health outcomes include endocrine disruption (5), oxidative stress (6) and inflammation (7) .  \nExposure to bisphenol A starts ","cbCaiouwLoc10KJd","https://ap.wps.com/l/cbCaiouwLoc10KJd","pdf",709972,"English","# Introduction\n# Methods\n## Study participants\n## Covariates collection\n# Results\n# Conclusion","[{\"question\":\"What dataset and exposure measure were used to study BPA and mortality?\",\"answer\":\"The study used NHANES data from 2003–2012. Urinary BPA was measured using liquid chromatography-mass spectrometry (LC–MS).\"},{\"question\":\"How was the relationship between urinary BPA and mortality analyzed?\",\"answer\":\"The analysis used multivariable Cox proportional hazard regressions and constrained cubic splines to assess associations with all-cause and cancer mortality, including checks for nonlinearity.\"},{\"question\":\"What was the main finding regarding cancer mortality risk?\",\"answer\":\"Cancer mortality risk showed a U-shaped association with urinary BPA. A lower BPA level below 1.99 ng/mL was associated with a higher risk of cancer mortality.\"}]","Endocrine disrupting chemical Bisphenol A and its association with cancer mortality: a prospective cohort study of NHANES | PDF",1789996109]