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\nBerlin Heidelberg New York Barcelona Hong Kong London Milan Paris Tokyo  \nManfred Schwab (Ed. )  \nEncyclopedic Reference of  \nCancer  \nWith 261 Figures and 64 Tables  \n1 3  \nManfred Schwab Professor for Genetics,  \nDirector, Division Cytogenetics -H-0400 German Cancer Research Center  \nIm Neuenheimer Feld 280 69120 Heidelberg Germany  \nISBN 3-540-66527-7 Springer-Verlag Berlin Heidelberg New York  \nLibrary of Congress Cataloging-in-Publication Data Schwab, M. (Manfred), 1945-  \nEncyclopedic reference of cancer / Manfred Schwab.  \n[p. cm](p. cm).  \nISBN 3540665277  \n1. Cancer±Encyclopedias. I. Title.  \nRC254 .5 .S393 2001  \n616.99'4'003±dc21 2001049122  \nThis work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.  \nSpringer-Verlag Berlin Heidelberg New York  \na member of BertelsmannSpringer Science+Business Media GmbH [http://www.springer.de](http://www.springer.de)  \nÓ Springer-Verlag Berlin Heidelberg 2001 Printed in Italy  \nThe use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.  \nProduct liability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant literature.  \nProduction Editor: Andreas Gsling, Heidelberg  \nTypesetting: Mitterweger & Partner Kommunikationsgesellschaft mbH, Plankstadt  \nCover design: Erich Kirchner, Heidelberg  \nPrinted on acid-free paper SPIN: 10731831 14/3130/ag 5 4 3 2 1 0  \nPreface  \nCancer, although a dreadful disease, is at the same time a fascinating biological phenotype. Around 1980, cancer was first attributed to malfunctioning genes and, subsequently, cancer research has become a major area of scientific research supporting the foundations of modern biology to a great extent. To unravel the human genome sequence was one of those extraordinary tasks, which has largely been fuelled by cancer research, and many of the fascinating insights into the genetic circuits that regulate developmental processes have also emerged from research on cancer. Diverse biological disciplines such as cytogenetics, virology, cell biology, classical and molecular genetics, epidemiology, biochemistry, together with the clinical sciences, have closed ranks in their search of how cancer develops and to find remedies to stop the abnormal growth that is characteristic of cancerous cells. In the attempt to establish how, why and when cancer occurs, a plethora of genetic pathways and regulatory circuits have been discovered that are necessary to maintain general cellular functions such as proliferation, differentiation and migration. Alterations ofthis fine-tuned network of cascades and interactions, due to endogenous failure or to exogenous challenges by environmental factors, may disable any member of such regulatory pathways. This could, for example, induce the death of the affected cell, may mark it for cancerous development or may immediately provide it with a growth advantage within a particular tissue.  \nRecent developments have seen the merger of basic and clinical science. Of the former, particularly genetics has provided instrumental and analytical tools with which to assess the role of enviro","cbCaiuVoJj4jJ6pq","https://ap.wps.com/l/cbCaiuVoJj4jJ6pq","pdf",10887477,1017,"English","# Preface\n## Cancer as a biological phenotype\n## Advances from basic and clinical science\n## Encyclopedia aims and audience\n## Multi-author coverage and editorial approach","[{\"question\":\"What perspective does the preface use to describe cancer research?\",\"answer\":\"It describes cancer as both a dreadful disease and a fascinating biological phenotype, and it emphasizes how cancer research has advanced modern biology through genetics and molecular insights.\"},{\"question\":\"How does the work intend to bridge basic and clinical science?\",\"answer\":\"It calls for a comprehensive reference source that serves both as a tool to close the language gap between investigators and as an information platform for students and informed lay readers.\"},{\"question\":\"Why is the encyclopedia presented as a multi-author effort?\",\"answer\":\"The preface explains that no single individual can cover the field with undisputed authority, so many expert authors contribute keyword definitions and in-depth essays, allowing broad coverage in one publication.\"}]","Encyclopedic Reference of Cancer - Preface | PDF",1789974039,2563]