[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375883-105":59,"doc-detail-375883-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","enabling-tumor-specific-drug-delivery-by-targeting-the-warburg-effect-of-cancer","Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer","","Cancer therapies often fail because drugs struggle to reach tumor tissue effectively while harming healthy organs. This study develops a lactate-responsive drug delivery platform that targets the Warburg effect, a metabolic hallmark marked by lactate accumulation in tumor microenvironments. Janus gold/mesoporous silica nanoparticles function as gated carriers: lactate oxidase generates hydrogen peroxide, triggering arylboronate self-immolation to uncage drugs and release them. 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Targeting this feature enables drug release preferentially in tumor microenvironments.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the lactate-responsive Janus nanoparticle system work?",{"text":118,"@type":114},"The system uses Janus gold/mesoporous silica nanoparticles where lactate oxidase produces hydrogen peroxide in the presence of lactate. 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With Janus nanoparticles, drugs can be released by elevated lactate levels in the tumor microenvironment, enhancing delivery specificity and therapeutic efficacy. This system provides a promising approach for targeted cancer therapy by leveraging cancer metabolism.  \nd The Warburg effect (lactate accumulation) is a key feature of cancer cells  \nd A lactate-responsive drug delivery system is developed to target this feature  \nd It uses Janus nanoparticles with lactate-triggered drug release  \nd It improves drug delivery specificity and effectiveness for cancer treatment  \nZhang et al., 2025, Cell Reports Medicine 6, 101920  \nJanuary 21, 2025 ª 2024 The Author(s) . Published by Elsevier Inc.  \n[https://doi.org/10.1016/j.xcrm.2024.101920](https://doi.org/10.1016/j.xcrm.2024.101920)  \nll  \nll  \nOPEN ACCESS  \nArticle  \nEnabling tumor-specific drug delivery by targeting the Warburg effect of cancer  \nJian Zhang,1,2,9 Tony Pan,3,9 Jimmy Lee,2,4,9 Sanja Goldberg,5 Sarah Ann King,2 Erting Tang,3 Yifei Hu,3 Lifeng Chen,2 Alex Hoover,3 Linyong Zhu,6 Oliver S. Eng,7 Benjamin Dekel,5,8 Jun Huang,3,* and Xiaoyang Wu2,10,*  \n1Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA  \n2Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA  \n3Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA  \n4Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan  \n5Pediatric Stem Cell Research Institute, Safra Children’s Hospital, Sheba Medical Center, Tel Aviv, Israel  \n6Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China  \n7Department of Surgery, University of California, Irvine, Orange, CA 92868, USA  \n8Division of Pediatric Nephrology and Pediatric Stem Cell Research Institute, Safra Children’s Hospital, Sheba Medical Center, Tel Hasomer, Sago Center for Regenerative Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel  \n9These authors contributed equally  \n10Lead contact  \n*Correspondence: [huangjun@uchicago.edu](huangjun@uchicago.edu) (J.H.), [xiaoyangwu@uchicago.edu](xiaoyangwu@uchicago.edu) (X.W.) [https://doi.org/10.1016/j.xcrm.2024.101920](https://doi.org/10.1016/j.xcrm.2024.101920)  \nSUMMARY  \nMetabolic reprogramming of tumor cells is an emerging hallmark of cancer. Among all the changes in cancer metabolism, increased glucose uptake and the accumulation of lactate under normoxic conditions (the ‘‘Warburg effect’’) is a common feature of cancer cells. In this study, we develop a lactate-responsive drug delivery platform by targeting the Warburg effect. We design and test a gold/mesoporous silica Janus nanoparticle system as a gated drug carrier, in which the gold particles are functionalized with lactate oxidase and the silica particles are capped with a-cyclodextrin through surface arylboronate modification. In the presence of lactate, the lactate oxidase generates hydrogen peroxide, which induces the selfimmolation reaction of arylboronate, leading to uncapping and drug release. Our results demonstrate greatly improved drug delivery specificity and therapeutic efficacy with this platform for the treatment of different cancers. Our findings present an effective approach for drug","cbCaikya5ZH0hrW4","https://ap.wps.com/l/cbCaikya5ZH0hrW4","pdf",7723006,27,"English","# Summary\n# Key platform concept\n# Introduction\n# Tumor microenvironment and metabolic targeting","[{\"question\":\"What is the Warburg effect and why is it targeted for drug delivery?\",\"answer\":\"The Warburg effect refers to lactate accumulation in cancer cells under normoxic conditions. Targeting this feature enables drug release preferentially in tumor microenvironments.\"},{\"question\":\"How does the lactate-responsive Janus nanoparticle system work?\",\"answer\":\"The system uses Janus gold/mesoporous silica nanoparticles where lactate oxidase produces hydrogen peroxide in the presence of lactate. Hydrogen peroxide triggers arylboronate self-immolation, causing uncapping and drug release.\"},{\"question\":\"What results does the platform aim to improve for cancer treatment?\",\"answer\":\"The platform is designed to greatly improve drug delivery specificity and therapeutic efficacy, supporting targeted therapy based on cancer metabolism.\"}]","Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer | PDF",1790216451,68]