[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332444-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332444-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","emp3-a-promising-biomarker-for-tumor-prognosis-and-targeted-cancer-therapy","EMP3 - A promising biomarker for tumor prognosis and targeted cancer therapy","","Epithelial membrane protein 3 (EMP3) is a member of the peripheral myelin protein 22 kDa (PMP22) gene family, featuring four transmembrane domains and broad expression across human tissues and organs. Similar PMP22-family members (EMP1, EMP2, PMP22) have been implicated in multiple cancers, yet limited work addresses EMP3’s role in tumorigenicity. EMP3 is reported to regulate immune-cell functions and to participate in signaling pathways including HER-2/PI3K/Akt, MAPK/ERK, and TGF-beta/Smad, also linking to proliferation and apoptosis. The review summarizes EMP3 structure and function and its associations with diverse cancers, highlighting its potential as a prognostic biomarker and therapeutic target.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/emp3-a-promising-biomarker-for-tumor-prognosis-and-targeted-cancer-therapy/332444/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/emp3-a-promising-biomarker-for-tumor-prognosis-and-targeted-cancer-therapy/332444.png","ImageObject",300,407,{"name":42,"@type":43},"Theodore","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-14","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is EMP3 and where is it expressed?","Question",{"text":63,"@type":64},"EMP3 (epithelial membrane protein 3) belongs to the PMP22 gene family and contains four transmembrane domains. It shows widespread expression across various human tissues and organs.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is EMP3 considered relevant to cancer development?",{"text":68,"@type":64},"EMP3 is associated with critical signaling pathways such as HER-2/PI3K/Akt, MAPK/ERK, and TGF-beta/Smad. It is also linked to cell cycle regulation, cellular proliferation, and apoptosis.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the review conclude about EMP3 in tumor prognosis and therapy?",{"text":72,"@type":64},"EMP3 is expected to serve as a significant biological marker for tumor prognosis and as a potential target in cancer therapeutics, based on its structure, function, and cancer associations.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332444,1790218476,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Cancer Biomarkers 40 (2024) 227–239 227  \nDOI 10.3233/CBM-230504 IOS Press  \nEMP3: A promising biomarker for tumor prognosis and targeted cancer therapy  \nWenjing Zhua , Shu Songb , Yangchun Xua , Hanyue Shenga and Shuang Wanga ;􀀃  \na Department of Dermatology, The Second Hospital of Jilin University, Changchun, Jilin, China  \nb Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada  \nReceived 15 November 2023 Accepted 19 July 2024  \nAbstract. Epithelial membrane protein 3 (EMP3) belongs to the peripheral myelin protein 22 kDa (PMP22) gene family, characterized by four transmembrane domains and widespread expression across various human tissues and organs. Other members of the PMP22 family, including EMP1, EMP2, and PMP22, have been linked to various cancers, such as glioblastoma, laryngeal cancer, nasopharyngeal cancer, gastric cancer, breast cancer, and endometrial cancer. However, few studies report on the function and relevance of EMP3 in tumorigenicity. Given the significant structural similarities among members of the PMP22 family, there are likely potential functional similarities as well. Previous studies have established the regulatory role of EMP3 in immune cells like T cells and macrophages. Additionally, EMP3 is found to be involved in critical signaling pathways, including HER- 2/PI3K/Akt, MAPK/ERK, and TGF-beta/Smad. Furthermore, EMP3 is associated with cell cycle regulation, cellular proliferation, and apoptosis. Hence, it is likely that EMP3 participates in cancer development through these aforementioned pathways and mechanisms. This review aims to systematically examine and summarize the structure and function of EMP3 and its association to various cancers. EMP3 is expected to emerge as a significant biological marker for tumor prognosis and a potential target in cancer therapeutics.  \nKeywords: Epithelial membrane protein 3, cancer, transmembrane protein, signaling pathway, glioma  \n1. Introduction  \nThe peripheral myelin protein 22 kDa (PMP22) gene family encompasses several members, including epithelial membrane protein1, 2, and 3 (EMP1, EMP2, EMP3), PMP22, p53 apoptosis effect related to PMP22 (PERP), lens fiber cell protein MP20 (also named LIM2), and brain cell membrane protein [1] . Genes within this family are implicated in cellular proliferation, migration, and invasion and have active roles in tumor development [2]. Members of the PMP22 family share significant structural similarities and homology, suggesting potential overlap in function and involve-  \n􀀃 Corresponding author: Shuang Wang, Department of Dermatology, The Second Hospital of Jilin University, No.218, Ziqiang street, Changchun, Jilin 130041, China. Tel.: +86 15526852052; E-mail: [swang@jlu.edu.cn](swang@jlu.edu.cn).  \nment in cancer. PMP22 proteins are hydrophobic and approximately 160 amino acids long, containing two extracellular domains, four transmembrane domains, and small intracellular regions [3] . The amino acid sequence homology of EMP3 with PMP22, EMP1, EMP2 and MP20 is 41%, 33%, 38% and 23%, respectively. EMP3, PMP22, and EMP2 share the same C-terminal residue, suggesting that this motif may have functional importance as it closely resembles the retrieval signal of endoplasmic reticulum proteins [4] . Within the EMP protein family, all members feature N-glycosylation sites and share a highly conserved transmembrane domain [3] . There are notable structural differences between EMPs. EMP3 lacks a functional site for phosphorylation by casein kinase 2, whereas EMP1 and EMP2 contain the target site. EMP2 and EMP3 share similar molecular structures, both featuring an N-terminal glycosylation site in their first hydrophilic domain and  \nISSN 1574-0153 􀀍c 2024 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4 .0) .  \n228 W. Zhu et al. / EMP3: A promising bioma","cbCaihWjjA0BCS6x","https://ap.wps.com/l/cbCaihWjjA0BCS6x","pdf",4639376,13,"English","# Introduction\n## PMP22 gene family and structural features\n## Evidence linking PMP22-family genes to cancer\n## EMP3 functions and signaling pathways","[{\"question\":\"What is EMP3 and where is it expressed?\",\"answer\":\"EMP3 (epithelial membrane protein 3) belongs to the PMP22 gene family and contains four transmembrane domains. It shows widespread expression across various human tissues and organs.\"},{\"question\":\"Why is EMP3 considered relevant to cancer development?\",\"answer\":\"EMP3 is associated with critical signaling pathways such as HER-2/PI3K/Akt, MAPK/ERK, and TGF-beta/Smad. It is also linked to cell cycle regulation, cellular proliferation, and apoptosis.\"},{\"question\":\"What does the review conclude about EMP3 in tumor prognosis and therapy?\",\"answer\":\"EMP3 is expected to serve as a significant biological marker for tumor prognosis and as a potential target in cancer therapeutics, based on its structure, function, and cancer associations.\"}]","EMP3 - A promising biomarker for tumor prognosis and targeted cancer therapy | PDF",1789998223,33]