[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333113-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-333113-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","emerging-trajectories-for-next-generation-tissue-engineers","Emerging Trajectories for Next Generation Tissue Engineers","","The perspective traces how tissue engineering has advanced from early efforts to create engineered tissue substitutes toward building human tissues for regenerative medicine and for mechanistic studies of tissue disease, injury, and regeneration. Progress in bioengineering, materials science, and stem cell biology has supported major breakthroughs. Reflecting on the September 2021 virtual Next Generation Tissue Engineering symposium and trainee workshop, the authors project developments for the next 15 years.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/emerging-trajectories-for-next-generation-tissue-engineers/333113/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/emerging-trajectories-for-next-generation-tissue-engineers/333113.png","ImageObject",300,407,{"name":42,"@type":43},"Gelato","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How has tissue engineering evolved according to the perspective?","Question",{"text":63,"@type":64},"It progressed from engineering tissue substitutes to current efforts focused on building human tissues for regenerative medicine and mechanistic studies of disease, injury, and regeneration.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which advances are highlighted as enabling key developments?",{"text":68,"@type":64},"Advances in bioengineering, materials science, and stem cell biology are described as major drivers of progress in the field.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the authors’ projection focus on for the coming years?",{"text":72,"@type":64},"The perspective reflects on the 2021 symposium and workshop and provides projections for how the field may develop over the next 15 years, including directions for clinical translation and emerging tools.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333113,1790574648,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":106,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},19241457091524,"https://us-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[pubs.acs.org/journal/abseba](pubs.acs.org/journal/abseba)  Perspective   \nEmerging Trajectories for Next Generation Tissue Engineers  \nDaniel Naveed Tavakol,† Sharon Fleischer,† Thomas Falcucci,† Pamela L. Graney,† Susan P. Halligan, David L. Kaplan,* and Gordana Vunjak-Novakovic *  \n Cite This: [https://doi.org/10.1021/acsbiomaterials.1c01428](https://doi.org/10.1021/acsbiomaterials.1c01428)  \nRead Online  \n\n| ACCESS |  Metrics & More |  Article Recommendations |\n| --- | --- | --- |\n\nDownloaded via PURDUE UNIV on January 10, 2022 at 18:10:21 (UTC) . See [https://pubs.acs.org/sharingguidelines](https://pubs.acs.org/sharingguidelines) for options on how to legitimately share published articles.  \nABSTRACT: The field of tissue engineering has evolved from its early days of engineering tissue substitutes to current efforts at building human tissues for regenerative medicine and mechanistic studies of tissue disease, injury, and regeneration. Advances in bioengineering, material science, and stem cell biology have enabled major developments in the field. In this perspective, we reflect on the September 2021 virtual Next Generation Tissue Engineering symposium and trainee workshop, as well as our projections for the field over the next 15 years.  \nKEYWORDS: tissue engineering, bioengineering, regenerative medicine, biomaterials  \n■ TISSUE ENGINEERING: THE NEXT GENERATION  \n(2005)  \nIn May 2005, the first Tissue Engineering: The Next Generation meeting was held in Boston, with cochairs Profs. Gordana Vunjak-Novakovic and David Kaplan bringing together the current and emerging leaders in the then newly developing field.1,2 From its early beginnings in the 1980s and 1990s, tissue engineering as a field was primarily focused on the use of cells as materials for replacement and regeneration of damaged organs in the body. In 2005, the majority of investigators were focused on exploiting developmental biology to control stem and progenitor cell fate and engineering functional replacements for a few key tissues, including cartilage, bone and heart muscle. In addition, emphasis was placed on advancing from monolithic and static biomaterials to more complex and dynamic biomaterials. The meeting highlighted the need for cross-disciplinary approaches to advance and inform the design of tissue systems.  \n■ TISSUE ENGINEERING: THE NEXT GENERATION  \n(2021)  \nJust over 15 years and a global pandemic later, the second major gathering was held in September 2021 virtually over Zoom, co-organized again by Profs. Gordana VunjakNovakovic and David Kaplan, with the goal to further explore the foundations of tissue engineering and its clinical translation, well past the expectations envisioned in the inaugural meeting. Since 2005, there have been major developments in related fields, including stem cell biology, molecular biology,  \nand materials science. The advent of critical new tools to manipulate cells, including induced pluripotent stem cells (iPSCs) and gene editing technologies, has provided an increased motivation for designing personalized approaches to tissue engineering, further facilitating clinical translation of patient-specific treatments.3 To that end, the field has expanded from a focus solely on engineered tissues for replacement or regeneration of human organs, to human tissue models to better understand biology, disease, and toxicity in vitro.4,5 Leaders of the field in academia, industry, and government agencies gathered together to discuss biological principles, enabling technologies, and scientific barriers for translating engineered tissues of increasing biological fidelity into products benefiting the patients.  \nOn day 1 of the symposium (September 22, 2021), the program began with a keynote lecture from MIT’s Dr. Robert Langer on technologies that enabled the development of tissue engineering as a field, from early antiangiogenic controlled therapeutics, biomaterials, and controlled delivery systems. Day 1 continued with sessions on (i) Biolo","cbCaicLcyo1Io3m0","https://ap.wps.com/l/cbCaicLcyo1Io3m0","pdf",2066628,"English","# Abstract\n# Tissue Engineering: The Next Generation (2005)\n# Tissue Engineering: The Next Generation (2021)\n# Symposium Program (September 22, 2021)\n# Symposium Program (September 23, 2021)","[{\"question\":\"How has tissue engineering evolved according to the perspective?\",\"answer\":\"It progressed from engineering tissue substitutes to current efforts focused on building human tissues for regenerative medicine and mechanistic studies of disease, injury, and regeneration.\"},{\"question\":\"Which advances are highlighted as enabling key developments?\",\"answer\":\"Advances in bioengineering, materials science, and stem cell biology are described as major drivers of progress in the field.\"},{\"question\":\"What does the authors’ projection focus on for the coming years?\",\"answer\":\"The perspective reflects on the 2021 symposium and workshop and provides projections for how the field may develop over the next 15 years, including directions for clinical translation and emerging tools.\"}]","Emerging Trajectories for Next Generation Tissue Engineers | PDF",1790000933,18]