[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-362127-105":59,"doc-detail-362127-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-roles-of-pseudogene-derived-lncrnas-in-cancer-stem-cells-non-coding-clues-and-therapeutic-targets-in-cancer-medicine","Emerging roles of pseudogene-derived lncRNAs in cancer stem cells - Non-coding clues and therapeutic targets in cancer medicine","","Cancer stem cells (CSCs) are progenitor tumor cells with stemness traits that drive cancer onset, progression, metastasis, relapse, and resistance to chemotherapy. Although the precise molecular basis of CSC development remains incompletely understood, evidence highlights regulatory pathways in which non-coding RNAs play major roles. This review focuses on how pseudogene-derived lncRNAs dysregulation influences CSC formation across cancers and how these RNAs can guide biomarker, diagnostic, and therapeutic target discovery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-roles-of-pseudogene-derived-lncrnas-in-cancer-stem-cells-non-coding-clues-and-therapeutic-targets-in-cancer-medicine/362127/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-roles-of-pseudogene-derived-lncrnas-in-cancer-stem-cells-non-coding-clues-and-therapeutic-targets-in-cancer-medicine/362127.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are cancer stem cells (CSCs) and what roles do they play in cancer?","Question",{"text":112,"@type":113},"CSCs are a tumor cell subpopulation whose stemness-related behaviors contribute to cancer growth, metastasis, relapse, and chemotherapy resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do pseudogene-derived lncRNAs relate to CSC development?",{"text":117,"@type":113},"Some pseudogenes are transcribed into lncRNAs that can functionally and structurally resemble typical lncRNAs, affecting CSC development mainly through miRNA sponge mechanisms and modulation of CSC-related signaling pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic and diagnostic potential does this review emphasize?",{"text":121,"@type":113},"Dysregulated pseudogene-derived lncRNAs may reveal hidden aspects of CSC development and support the development of novel therapeutic and diagnostic targets, including biomarker-based approaches.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},362127,1790197829,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Genes & Diseases (2026) 13, 101793  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \nScienceDirect  \njournal [homepage:](homepage: www . keaipublishing. com/en/journals/genes-diseases)[ www . keaipublishing. com/en/journals/genes-diseases](homepage: www . keaipublishing. com/en/journals/genes-diseases)  \nREVIEW ARTICLE  \nEmerging roles of pseudogene-derived lncRNAs in cancer stem cells: Non-coding clues and therapeutic targets in  \ncancer medicine  \nSeyed Taha Nourbakhsh a, Fatemeh Mohamadhashem b, Elahe Soltani Fard c,d, Faezeh Mohamadhashem e,** , Abdolreza Daraei f,g,*  \na Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord 8815713471, Iran  \nb Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran 1461884513, Iran  \nc Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord 8815713471, Iran  \nd Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord 8815713471, Iran  \ne Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 8815713471, Iran  \nf Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol 47176-47745, Iran  \ng Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol 47176-47745, Iran  \nReceived 16 January 2025; accepted 11 April 2025 Available online 7 August 2025  \nKEYWORDS  \nCancer stem cells (CSCs);  \nceRNA network; Pseudogene-derived  \nAbstract Cancer stem cells (CSCs), progenitor tumor cells with stemness characteristics, play key roles in cancer’s onset, progression, metastasis, relapse, and chemotherapy resistance. While the exact molecular mechanisms of CSC development are not fully understood, recent research has revealed regulatory pathways of their generation with the weighty involvement of non-coding RNAs. It has been found that some pseudogenes are transcribed to long non-coding RNAs (lncRNAs), which are functionally and structurally similar to typical  \n* Corresponding author. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol 47176-47745, Iran.  \n** Corresponding author.  \nE-mail addresses: [faezeh.mohamadhashem@gmail.com](faezeh.mohamadhashem@gmail.com) (F. Mohamadhashem), [a.daraei@mubabol.ac.ir](a.daraei@mubabol.ac.ir) (A. Daraei).  \nPeer review under the responsibility of Chongqing Medical University.  \n[https://doi.org/10.1016/j.gendis.2025.101793](https://doi.org/10.1016/j.gendis.2025.101793)  \n2352-3042/© 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. , Ltd. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)).  \nlncRNAs;  \nSignalingpathways; Tumorigenesis  \nlncRNAs with biological functions including sponge miRNAs, antisense RNA, and interactions with proteins. Outstandingly, various in vitro and in vivo evidence have demonstrated that dysregulation of pseudogene-derived lncRNAs is directly involved in the development of CSCs indifferent cancers, mainly through functioning as miRNA sponges for modulating CSC-related signaling pathways. Therefore, researchers have suggested that research in this field can reveal hidden aspects of CSC development and can also open a new window for developing novel cancer therapeutic and diagnostic targets. In this review, we comprehensively address the recent findings of previous studies on the dysregulated roles of pseudogene-derived lncRNAs in directing and generating CSCs in various cancers. Also, their clinical capacities in terms of biomarkers, diagnosis, and treatment for cancer will be discussed.  \n© 2025 The Authors. Publishing services by Elsevier B.V.","cbCaivaecA3wJ7G0","https://ap.wps.com/l/cbCaivaecA3wJ7G0","pdf",4307285,16,"English","# Introduction\n## Non-coding RNAs and CSC regulation\n## Pseudogene-derived lncRNAs in cancer stem cells\n## Clinical implications: biomarkers, diagnosis, and treatment","[{\"question\":\"What are cancer stem cells (CSCs) and what roles do they play in cancer?\",\"answer\":\"CSCs are a tumor cell subpopulation whose stemness-related behaviors contribute to cancer growth, metastasis, relapse, and chemotherapy resistance.\"},{\"question\":\"How do pseudogene-derived lncRNAs relate to CSC development?\",\"answer\":\"Some pseudogenes are transcribed into lncRNAs that can functionally and structurally resemble typical lncRNAs, affecting CSC development mainly through miRNA sponge mechanisms and modulation of CSC-related signaling pathways.\"},{\"question\":\"What therapeutic and diagnostic potential does this review emphasize?\",\"answer\":\"Dysregulated pseudogene-derived lncRNAs may reveal hidden aspects of CSC development and support the development of novel therapeutic and diagnostic targets, including biomarker-based approaches.\"}]","Emerging roles of pseudogene-derived lncRNAs in cancer stem cells - Non-coding clues and therapeutic targets in cancer medicine | PDF",1790146538]