[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332458-105":59,"doc-detail-332458-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-roles-of-intratumor-microbiota-in-cancer-tumorigenesis-and-management-strategies","Emerging roles of intratumor microbiota in cancer - tumorigenesis and management strategies","","The intricate interplay between the host and its microbiota has drawn growing attention, particularly the recognition of microorganisms residing within diverse, previously presumed sterile cancer tissues. This review summarizes four proposed migratory routes for intratumoral microbial “dark matter” and explains how heterogeneous intratumor microbiota contribute to tumor initiation and progression through genetic alterations, epigenetic changes, immune dysfunction, activation of oncogenic pathways, and metastasis. It also highlights emerging microbiota-based approaches for early diagnosis and prognosis, and the impact of intratumor microbiota on therapeutic efficacy, especially immunotherapy. Finally, it outlines the developmental history, origin, carcinogenic mechanisms, predictive and intervention potential, and key challenges for personalized cancer management strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-roles-of-intratumor-microbiota-in-cancer-tumorigenesis-and-management-strategies/332458/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-roles-of-intratumor-microbiota-in-cancer-tumorigenesis-and-management-strategies/332458.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the proposed sources of intratumor microbiota in cancer tissues?","Question",{"text":112,"@type":113},"The review identifies four potential migratory routes: direct invasion of mucosal barriers, spreading from adjacent normal tissue, hematogenous spread, and lymphatic drainage.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can intratumor microbiota contribute to cancer development and progression?",{"text":117,"@type":113},"Intratumor microbiota may drive initiation and progression via genetic alterations, epigenetic modifications, immune dysfunction, activation of oncogenic pathways, and promotion of metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"How does intratumor microbiota affect cancer treatment outcomes, especially immunotherapy?",{"text":121,"@type":113},"The review states that intratumor microbiota significantly influences the efficacy of cancer therapeutics, with a particular impact on immunotherapy, making it an attractive intervention target.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332458,1790163424,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Shi et al. Journal of Translational Medicine (2024) 22:837  \n[https://doi.org/10.1186/s12967-024-05640-7](https://doi.org/10.1186/s12967-024-05640-7)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nEmerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies  \nZhuangzhuang Shi1,2, Zhaoming Li1,2* and Mingzhi Zhang1,2*  \nAbstract  \nThe intricate interplay between the host and its microbiota has garnered increasing attention in the past decade. Specifically, the emerging recognition of microorganisms within diverse cancer tissues, previously presumed sterile, has ignited a resurgence of enthusiasm and research endeavors. Four potential migratory routes have been identified as the sources of intratumoral microbial “dark matter,” including direct invasion of mucosal barriers, spreading from normal adjacent tissue, hematogenous spread, and lymphatic drainage, which contribute to the highly heterogeneous features of intratumor microbiota. Importantly, multitudes of studies delineated the roles of intratumor microbiota in cancer initiation and progression, elucidating underlying mechanisms such as genetic alterations, epigenetic modifications, immune dysfunctions, activating oncogenic pathways, and inducing metastasis. With the deepening understanding of intratumoral microbial composition, novel microbiota-based strategies for early cancer diagnosis and prognostic stratification continue to emerge. Furthermore, intratumor microbiota exerts significant influence on the efficacy of cancer therapeutics, particularly immunotherapy, making it an enticing target for intervention in cancer treatment. In this review, we present a comprehensive discussion of the current understanding pertaining to the developmental history, heterogeneous profiles, underlying originations, and carcinogenic mechanisms of intratumor microbiota, and uncover its potential predictive and intervention values, as well as several inevitable challenges as a target for personalized cancer management strategies.  \nKeywords Intratumor microbiota, Cancer, Tumorigenesis, Immunotherapy, Biomarker, Personalized cancer therapy  \nIntroduction  \nThe human microbiota encompasses a vast number of interacting microorganisms, including bacteria, viruses, fungi, and archaea, inhabiting various locations both on human surfaces and within the body [1]. Thereinto, the  \n*Correspondence: Zhaoming Li [fcclizm@zzu.edu.cn](fcclizm@zzu.edu.cn)[ ](fcclizm@zzu.edu.cn)Mingzhi Zhang [mingzhi_zhang1@163.com](mingzhi_zhang1@163.com)  \n1 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China  \n2 Lymphoma Diagnosis and Treatment Centre of Henan Province, Zhengzhou 450000, China  \ngastrointestinal tract, particularly the colon, stands out as the largest microecosystem, harboring several trillion microbial cells [2]. Moreover, the gene set among the resident microbes surpasses that of the human host by more than 100 times [3]. Once as a “forgotten organ”, the gut microflora has been extensively demonstrated over the past decade to play a pivotal role in upholding host homeostasis, which serves as a significant determinant in the variability of disease occurrence, progression, and therapeutic response [4, 5]. Thanks to advancements in modern sequencing and metagenomics techniques, it has become evident that human tissues and organs, including tumor tissues (excluding those on body surfaces or in cavities), are not entirely sterile but rather harbor  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission unde","cbCaiv3losJqudnX","https://ap.wps.com/l/cbCaiv3losJqudnX","pdf",2537143,31,"English","# Introduction\n## Human microbiota and gut microecosystem\n## Intratumor microbiota and cancer relevance\n## Oncomicrobes and carcinogenic microbes\n# Emerging roles in tumorigenesis and management strategies\n## Migratory origins and heterogeneity\n## Mechanisms in initiation and progression\n## Microbiota-based diagnosis and prognostic stratification\n## Influence on cancer therapeutics, especially immunotherapy\n## Challenges for personalized management","[{\"question\":\"What are the proposed sources of intratumor microbiota in cancer tissues?\",\"answer\":\"The review identifies four potential migratory routes: direct invasion of mucosal barriers, spreading from adjacent normal tissue, hematogenous spread, and lymphatic drainage.\"},{\"question\":\"How can intratumor microbiota contribute to cancer development and progression?\",\"answer\":\"Intratumor microbiota may drive initiation and progression via genetic alterations, epigenetic modifications, immune dysfunction, activation of oncogenic pathways, and promotion of metastasis.\"},{\"question\":\"How does intratumor microbiota affect cancer treatment outcomes, especially immunotherapy?\",\"answer\":\"The review states that intratumor microbiota significantly influences the efficacy of cancer therapeutics, with a particular impact on immunotherapy, making it an attractive intervention target.\"}]","Emerging roles of intratumor microbiota in cancer - tumorigenesis and management strategies | PDF",1789998291,78]