[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327430-105":59,"doc-detail-327430-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-roles-of-circular-rnas-in-regulating-the-hallmarks-of-thyroid-cancer","Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer","","Thyroid cancer is a prevalent endocrine malignancy with rising incidence and significant mortality when tumors recur, metastasize, resist radioiodine therapy, or lose differentiation. While the mechanisms behind these malignant traits remain incompletely understood, circular RNAs are closed-loop non-coding RNAs implicated in multiple aspects of cancer biology. This review consolidates circular RNAs reported in thyroid cancer over the past decade through the framework of the 14 hallmarks of cancer. Eight of the 14 hallmarks are shown to be regulated by circular RNAs, whereas six lack reported correlations. The synthesis aims to clarify circRNA functions, support mechanism research, and accelerate therapeutic strategy development.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-roles-of-circular-rnas-in-regulating-the-hallmarks-of-thyroid-cancer/327430/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-roles-of-circular-rnas-in-regulating-the-hallmarks-of-thyroid-cancer/327430.png","ImageObject",300,407,{"name":92,"@type":93},"Ava Thompson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is understanding thyroid cancer mechanisms important?","Question",{"text":112,"@type":113},"Thyroid cancer can become refractory and leads to high mortality when it recurs, metastasizes, resists radioiodine therapy, or loses differentiation. The review highlights that the underlying mechanisms for these malignant characteristics are still unclear, motivating further investigation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do circular RNAs play in cancer biology?",{"text":117,"@type":113},"Circular RNAs are closed-loop non-coding RNAs generated through alternative splicing and are widely found in cancers. The text notes that circRNAs can promote or inhibit cancer development through multiple molecular mechanisms, including miRNA sponging, interaction with RNA-binding proteins, and protein encoding.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the review connect circular RNAs to the hallmarks of cancer?",{"text":121,"@type":113},"The review summarizes circRNAs identified in thyroid cancers over the past decade using the 14-hallmark cancer framework. It reports that eight of the 14 hallmarks are regulated by circular RNAs, while the other six currently have no reported association.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327430,1790930176,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1649267921044,"https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345","Cancer Gene [Therapy](Therapy www.nature.com/cgt)[ www.nature.com/cgt](Therapy www.nature.com/cgt)  \nREVIEW ARTICLE OPEN   \nEmerging roles of circular RNAs in regulating the hallmarks of thyroid cancer  \nTianjiao Zhou 1,2,3, Zheng Li 4, Yumeng Jiang 1,2,3, Kaiming Su1,2,3, Chuan Xu 4 ✉ and Hongliang Yi 1,2,3 ✉  \n© The Author(s) 2024  \n|  |  |  |\n| --- | --- | --- |\n|  | Thyroid cancer is a prevalent endocrine malignancy with increasing incidence in recent years. Although most thyroid cancers grow slowly, they can become refractory, leading to a high mortality rate once they exhibit recurrence, metastasis, resistance to radioiodine therapy, or a lack of differentiation. However, the mechanisms underlying these malignant characteristics remain unclear. Circular RNAs, a type of closed-loop non-coding RNAs, play multiple roles in cancer. Several studies have demonstrated that circular RNAs significantly influence the development of thyroid cancers. In this review, we summarize the circular RNAsidentified in thyroid cancers over the past decade according to the hallmarks of cancer. We found that eight of the 14 hallmarks of thyroid cancers are regulated by circular RNAs, whereas the other six have not been reported to be correlated with circular RNAs. This review is expected to help us better understand the roles of circular RNAs in thyroid cancers and accelerate research on the |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| mechanisms and cure strategies for thyroid cancers. |  |  |\n|  | Cancer Gene Therapy (2024) 31:507–516; [https://doi.org/10.1038/s41417-024-00736-0](https://doi.org/10.1038/s41417-024-00736-0) |  |\n|  |  |  |\n\nINTRODUCTION  \nThyroid cancer (TC) is a prevalent endocrine malignancy affecting approximately 586,000 individuals, resulting in 44,000 fatalities globally in 2020 [1] . Radiation is an environmental factor that elevates the risk of developing TC [2] . TC affects mostly females, and most thyroid cancers are discovered through ultrasound without specific clinical symptoms. After surgical treatment also, thyroid cancers have a recurrence rate as high as 10% [3] . Metastatic, locally advanced, and iodine-refractory thyroid cancers present formidable clinical challenges [4] . For instance, the median overall survival of patients with anaplastic TC (ATC) is only 0.79 years [5] . Therefore, a thorough investigation of the fundamental mechanisms underlying the pathogenesis of thyroid cancers is imperative to elucidate the intricate factors contributing to the varied clinical prognostic outcomes.  \n“The Hallmarks of Cancer” thoroughly explores the progress and discoveries in cancer research, spanning nearly a century, presenting a coherent framework for comprehending the varied phenotypes of cancers [6] . The third edition in 2022 expanded the number of cancer hallmarks to 14, from the previous eight presented in the second edition in 2011 [7], by introducing four new hallmarks: “unlocking phenotypic plasticity,” “non-mutant epigenetic reprogramming,” “polymorphic microbiome,c” and“senescent cells.” [8] Most of these hallmarks have been validated, inspiring investigations into their underlying mechanisms.  \nNon-coding RNAs (ncRNAs), once regarded as “non-functional,”have now been established as both oncogenic drivers and tumor suppressors across various major cancer types, providing a novel  \ndirection for understanding the diverse phenotypic manifestations of cancer [9–12] . Circular RNAs (circRNAs), a distinct subtype of ncRNAs, are generated by alternative splicing and occurs widely found in cancers. For instance, the CSCD-2 .0 database has unveiled over a million circRNAs in human cancers [13] .  \nCircRNAs play significant regulatory roles in cancers [13–15], promoting or inhibiting cancer development. Notable examples include circRHOBTB3, circCDYL, and circLRFN, which have been implicated in promoting colorectal cancer [14–16], breast cancer [17–19], and glioma [17,","cbCaic72jj5O69xA","https://ap.wps.com/l/cbCaic72jj5O69xA","pdf",3052550,"English","# Introduction\n## Thyroid cancer background and clinical challenges\n## The Hallmarks of Cancer framework\n## Non-coding RNAs and circular RNAs in cancer\n# Overview of functional circRNAs in thyroid cancer","[{\"question\":\"Why is understanding thyroid cancer mechanisms important?\",\"answer\":\"Thyroid cancer can become refractory and leads to high mortality when it recurs, metastasizes, resists radioiodine therapy, or loses differentiation. The review highlights that the underlying mechanisms for these malignant characteristics are still unclear, motivating further investigation.\"},{\"question\":\"What role do circular RNAs play in cancer biology?\",\"answer\":\"Circular RNAs are closed-loop non-coding RNAs generated through alternative splicing and are widely found in cancers. The text notes that circRNAs can promote or inhibit cancer development through multiple molecular mechanisms, including miRNA sponging, interaction with RNA-binding proteins, and protein encoding.\"},{\"question\":\"How does the review connect circular RNAs to the hallmarks of cancer?\",\"answer\":\"The review summarizes circRNAs identified in thyroid cancers over the past decade using the 14-hallmark cancer framework. It reports that eight of the 14 hallmarks are regulated by circular RNAs, while the other six currently have no reported association.\"}]","Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer | PDF",1789977188,25]