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CircRNAs and miRNAs often show aberrant expression in multiple cancers; circRNAs can act as miRNA sponges, shaping proliferation, apoptosis, invasion, autophagy, EMT, radiotherapy and chemotherapy responses, and immune evasion. The review highlights their biomarker potential for prognosis and diagnosis and discusses circRNA-miRNA circuits to inform targeted strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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\nContents lists available at ScienceDirect  \nNon-coding RNA Research  \njournal [homepage:](homepage: www.keaipublishing.com/en/journals/non-coding-rna-research)[ www.keaipublishing.com/en/journals/non-coding-rna-research](homepage: www.keaipublishing.com/en/journals/non-coding-rna-research)  \n| Emerging roles of CircRNA-miRNA networks therapeutic response |  |  | in cancer development and | |\n| --- | --- | --- | --- | --- |\n| Mehrdad Hashemi a,b, Elaheh Mohandesi Khosroshahi b, Pouria Daneii b, Aria Hassanpoor b, Maedeh Eslami b, Zeinab Khazaei Koohparc, Saba Asadib, Abbas Zabihid, Behdokht Jamalie, Amin Ghorbanib, Noushin Nabavif, Mohammad Reza Memarkashanig,\u003Cbr>Shokooh Salimimoghadam h, Afshin Taheriazamb,i,**, Shing Cheng Tanj, Maliheh Entezaria,b,*, Najma Farahanib,***, Kiavash Hushmandik\u003Cbr>a Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran b Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran c Department of Cell and Molecular Biology, Faculty of Biological Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran d Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Hamedan Branch, Hamedan, Iran\u003Cbr>e Department of Microbiology and Genetics, Kherad Institute of Higher Education, Bushehr, Iran f Independent Researcher, Victoria, British Columbia, V8V 1P7, Canada\u003Cbr>g Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran\u003Cbr>h Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University ofAhvaz, Ahvaz, Irani Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran\u003Cbr>j UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia k Department of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran |  |  |  |  |\n| A R T I C L E I N F O |  | A B S T R A C T |  |  |\n| Keywords: CircRNA miRNA\u003Cbr>Cancer therapy Chemoresistance\u003Cbr>Non-coding RNA |  | The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression. Circular RNAs (circRNAs), known for their covalently closed loop structures, are non-coding RNA molecules exceptionally resistant to enzymatic degradation, which enhances their stability and regulatory functions in cancer. Similarly, microRNAs (miRNAs) are endogenous noncoding RNAs with linear structures that regulate cellular biological processes akin to circRNAs. Both miRNAs and circRNAs exhibit aberrant expressions in various cancers. Notably, circRNAs can function as sponges for miRNAs, influencing their activity. The circRNA/miRNA interaction plays a pivotal role in the regulation of cancer progression, including in brain, gastrointestinal, gynecological, and urological cancers, influencing key processes such as proliferation, apoptosis, invasion, autophagy, epithelial-mesenchymal transition (EMT), and more. Additionally, this interaction impacts the response of tumor cells to radiotherapy and chemotherapy and contributes to immune evasion, a significant challenge in cancer therapy. Both circRNAs and miRNAs hold potential as biomarkers for cancer prognosis and diagnosis. In this review, we delve into the circRNA-miRNA circuit within human cancers, emphasizing their role in regulating cancer hallmarks and treatment responses. This discussion aims to provide insights for future research to better understand their functions and potentially guide targeted treatments for cancer patients using circRNA/miRNA-based strategies. |  |  |\n\n* Corresponding author. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islam","cbCaibC3nnbQx5Pt","https://ap.wps.com/l/cbCaibC3nnbQx5Pt","pdf",6909675,18,"English","# Introduction\n## CircRNAs and miRNAs in cancer progression\n## CircRNA/miRNA interactions and treatment response\n## Biomarker potential and future research directions","[{\"question\":\"What role do circRNAs and miRNAs play in cancer progression?\",\"answer\":\"CircRNAs and miRNAs are non-coding RNAs with aberrant expression in cancers and regulate tumor progression by influencing key molecular processes such as proliferation, apoptosis, invasion, autophagy, and EMT.\"},{\"question\":\"How do circRNA-miRNA interactions affect therapeutic response?\",\"answer\":\"CircRNA/miRNA interactions influence how tumor cells respond to radiotherapy and chemotherapy and can contribute to immune evasion, a major obstacle in cancer therapy.\"},{\"question\":\"Why are circRNAs and miRNAs considered potential biomarkers?\",\"answer\":\"Because both circRNAs and miRNAs show aberrant expression patterns in cancers, they can serve as biomarkers to support cancer prognosis and diagnosis.\"}]","Emerging roles of CircRNA-miRNA networks - therapeutic response in cancer development | PDF",1789982294,45]