[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338013-105":59,"doc-detail-338013-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-role-of-sirtuins-in-non-small-cell-lung-cancer-review","Emerging role of sirtuins in non-small cell lung cancer - Review","","Non-small cell lung cancer (NSCLC) is a highly prevalent lung malignancy with insidious onset and rapid progression, often reaching advanced stages before diagnosis, which makes radical surgery difficult. Sirtuins (SIRTs) are NAD+-dependent histone deacetylases that regulate aging-related changes in protein activity and stability. By modulating key tumor processes such as energy metabolism, autophagy, and apoptosis through deacetylation of histones or non-histone proteins, SIRTs are increasingly linked to NSCLC progression. This review synthesizes the roles of multiple SIRTs, their mechanisms, and SIRT-based therapeutic agents, providing new ideas and a theoretical basis for NSCLC treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-role-of-sirtuins-in-non-small-cell-lung-cancer-review/338013/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-role-of-sirtuins-in-non-small-cell-lung-cancer-review/338013.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is NSCLC difficult to treat with radical surgery?","Question",{"text":112,"@type":113},"NSCLC often has insidious onset and rapid progression, and many patients are diagnosed at advanced stages, making radical surgery impossible.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What are sirtuins (SIRTs) and what enables their function?",{"text":117,"@type":113},"SIRTs are histone deacetylases that require NAD+ for their activity, allowing them to regulate protein functions involved in multiple cellular and pathological processes.",{"name":119,"@type":110,"acceptedAnswer":120},"How do SIRTs contribute to NSCLC progression?",{"text":121,"@type":113},"SIRTs influence pathophysiological processes in tumor cells, including energy metabolism, autophagy, and apoptosis, through deacetylation of histones or non-histone proteins. They can act as tumor promoters or suppressors depending on context.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338013,1790791127,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","ONCOLOGY REPORTS 52: 127, 2024  \nEmerging role of sirtuins in non‑small cell lung cancer (Review)  \nMIN ZHOU 1,2* , LIN WEI 1,2* and RENFU LU 1,2  \n1  \nDepartment of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, P.R. China;  \n2  \nDepartment of Cardiothoracic Surgery, Chongqing Emergency Medical Center, Chongqing 400014, P.R. China  \nReceived April 4, 2024; Accepted July 15, 2024  \nDOI: 10. 3892/or.2024.8786  \nAbstract. Non‑small cell lung cancer (NSCLC) is a highly prevalent lung malignancy characterized by insidious onset, rapid progression and advanced stage at the time of diagnosis, making radical surgery impossible. Sirtuin (SIRT) is a histone deacetylase that relies on NAD+ for its function, regulating the aging process through modifications in protein activity and stability. It is intricately linked to various processes, including glycolipid metabolism, inflammation, lifespan regulation, tumor formation and stress response. An increasing number of studies indicate that SIRTs significantly contribute to the progression of NSCLC by regulating pathophysiological processes such as energy metabolism, autophagy and apoptosis in tumor cells through the deacetylation of histones or non‑histone proteins. The present review elaborates on the roles of different SIRTsand their mechanisms in NSCLC, while also summarizing novel therapeutic agents based on SIRTs. It aims to present new ideas and a theoretical basis for NSCLC treatment.  \nContents  \n1. Introduction  \n2. Relationship between SIRTs and NSCLC  \n3. Mechanisms of SIRTs in NSCLC  \n4. SIRT‑based treatment  \n5. Conclusions and prospects  \n1. Introduction  \nSirtuins (SIRTs) are members of a highly conserved protein family characterized by adenosine monophosphate  \nCorrespondence to: Dr Renfu Lu, Department of Cardiothoracic Surgery, Chongqing University Central Hospital, 1 Health Road, Yuzhong, Chongqing 400014, P.R. China  \nE‑mail: [lurenfu_surgery@163.com](lurenfu_surgery@163.com)  \n*Contributed equally  \nKey words: sirtuins, histone deacetylase, non‑small cell lung cancer, NAD+, apoptosis, autophagy  \n(AMP)‑transferring enzyme activity and histone deacetylase (HDAC) function, both of which are dependent on NAD+ (1) . As of now, seven SIRTs (SIRT1 to SIRT7) have been identified in human cells, each located in different subcellular compart‑ ments, collectively comprising the class III HDACs (2) . SIRT1, SIRT6 and SIRT7 are situated within the nucleus, while SIRT3, SIRT4 and SIRT5 are found in the mitochondria and SIRT2 is localized in the cytoplasm but can translocate to the nucleus to participate in certain functions when needed (3,4) . Mammalian SIRTs rely on their enzymatic activities and post‑translationally modify a variety of proteins, including both histones and non‑histone proteins. The modification can either initiate or inhibit the expression of downstream target proteins, which are involved in a variety of physiological mechanisms, including adenosine triphosphate synthesis, DNA repair, fatty acid metab‑ olism, glucose metabolism, insulin secretion and regulation of the cell cycle. When an organism is subjected to endogenous or exogenous stimuli, SIRTs participate in a variety of pathological processes including apoptosis, cellular autophagy, oxidative stress and inflammatory responses (5) . Lately, multiple studies have recognized the association of the SIRT family with the pathophysiology of various diseases, encompassing Alzheimer's disease, cancer, diabetes and obesity, as well as cardiovascular, inflammatory and neurodegenerative diseases. Lung cancer stands as the most prevalent cancer worldwide and it is the leading cause of cancer‑related death. Lung cancer is categorized into small cell lung cancer (SCLC) and non‑SCLC (NSCLC) on the basis of clinical and histopathologic features. Among them, NSCLC is a common type of lung cancer, encompassing lung adenocarcinoma, large‑cell lung cancer and squamous cell carcinoma, collectiv","cbCaiiOgnlsx34iE","https://ap.wps.com/l/cbCaiiOgnlsx34iE","pdf",2410140,13,"English","# Introduction\n# Relationship between SIRTs and NSCLC\n## Mechanisms of SIRTs in NSCLC\n## SIRT-based treatment\n## Conclusions and prospects","[{\"question\":\"Why is NSCLC difficult to treat with radical surgery?\",\"answer\":\"NSCLC often has insidious onset and rapid progression, and many patients are diagnosed at advanced stages, making radical surgery impossible.\"},{\"question\":\"What are sirtuins (SIRTs) and what enables their function?\",\"answer\":\"SIRTs are histone deacetylases that require NAD+ for their activity, allowing them to regulate protein functions involved in multiple cellular and pathological processes.\"},{\"question\":\"How do SIRTs contribute to NSCLC progression?\",\"answer\":\"SIRTs influence pathophysiological processes in tumor cells, including energy metabolism, autophagy, and apoptosis, through deacetylation of histones or non-histone proteins. They can act as tumor promoters or suppressors depending on context.\"}]","Emerging role of sirtuins in non-small cell lung cancer - Review | PDF",1790021576,33]