[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333471-105":59,"doc-detail-333471-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-role-of-rna-modification-and-long-noncoding-rna-interaction-in-cancer","Emerging role of RNA modification and long noncoding RNA interaction in cancer","","Emerging role of RNA modification and long noncoding RNA interaction in cancer reviews how nonprotein-coding regions shape cancer biology through long noncoding RNAs (lncRNAs) and diverse RNA modifications. It describes lncRNA structural variety and their regulation of gene transcription, epigenetic control, RNA processing, and signaling pathways linked to tumor proliferation, metabolism, apoptosis, and drug resistance. The article further summarizes major RNA modification types, emphasizing m6A writers, erasers and readers and highlighting their dynamic, reversible control of cancer progression. It presents dysregulated lncRNA expression and RNA epigenetic pathways as potential targets for diagnosis and therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-role-of-rna-modification-and-long-noncoding-rna-interaction-in-cancer/333471/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-role-of-rna-modification-and-long-noncoding-rna-interaction-in-cancer/333471.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What roles do long noncoding RNAs play in cancer progression?","Question",{"text":112,"@type":113},"Long noncoding RNAs regulate gene transcription, epigenetic states, RNA processing and stability, and influence signaling pathways related to tumor growth, apoptosis, and drug resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is RNA modification linked to the concept of epigenetics in cancer?",{"text":117,"@type":113},"RNA epigenetics involves changes in gene expression without altering DNA sequence, and RNA modifications—including methylation and other chemical edits—contribute to disease pathogenesis, including cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"How does m6A modification occur and why is it important?",{"text":121,"@type":113},"m6A is installed by “writers” (methylase complexes), removed by “erasers” (demethylases), and recognized by “readers.” This dynamic and reversible regulation affects RNA function and cancer progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333471,1790183536,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","[www.nature.com/cgt](www.nature.com/cgt) Cancer Gene Therapy  \nREVIEW ARTICLE OPEN   \nEmerging role of RNA modification and long noncoding RNA interaction in cancer  \nLiqiong Yang 1,2,3, Lu Tang1,2,3, Qi Min 1,2,3, Hua Tian 1,2,3, Linwei Li4, Yueshui Zhao1,2,3, Xu Wu1,2,3, Mingxing Li1,2,3, Fukuan Du1,2,3, Yu Chen1,2,3, Wanping Li1,2,3, Xiaobing Li 1,2,3, Meijuan Chen 1,2,3, Li Gu1,2,3, Yuhong Sun1,2,3, Zhangang Xiao 1,2,3 ✉ and  \nJing Shen 1,2,3 ✉  \n© The Author(s) 2024  \nINTRODUCTION  \nIn recent years, more and more researchers have focused on nonprotein-coding genomes. 70% of the transcribed human genome corresponds to noncoding RNAs (ncRNA) [1] . Long noncoding RNAs (lncRNAs) are a group of ncRNAs over 200 nucleotides in length. The structures of lncRNA are complex and diverse, including linear, circular, Y-shaped, U-shaped, and other shapes. In addition, lncRNAs tend to fold into complex secondary and tertiary structures and interact with proteins, DNA, and other RNAs, regulating the activity of multi-protein complexes and DNA targets. These special structures can not only affect the function of lncRNA, but also affect their stability and interaction [2] . The functions of lncRNA are highly diversified. For example, lncRNA can regulate gene transcription by acting as decoys or guiding chromatin modifiers. They can also function as recruiters and scaffolds for other regulatory factors involved in epigenetic modifications. In addition, they are also implicated in mRNA processing, splicing, stability, or translation. In the cytoplasm, lncRNAs may act as scaffolds to bring two or more proteins into spatial proximity to each other [3, 4] . Therefore, lncRNAs can execute a variety of molecular functions, including epigenetic regulation, transcriptional regulation, post-transcriptional regulation, miRNA regulation, and regulating the activity of proteins or altering their cellular localization [5] . LncRNAs can also participate in multiple signal pathways of cancer (such as p53, AKT, or Notch), epigenetic control, DNA damage, multiple biological functions (e.g., tumor proliferation, metabolism, and apoptosis, etc.), aerobic  \nglycolysis, and microRNA control, etc., suggesting that they are important players in cancer [6–14] . Aberrant expression of lncRNAs can affect the occurrence, progress, and drug resistance of cancer [15] . In recent years, many reviews have summarized the role of lnRNA in cancer [16, 17] . For example, lncRNA HULC promotes breast cancer metastasis and cisplatin resistance by targeting the IGF1R-PI3K-AKT axis in trans [18] . Therefore, the multifaceted functions of lncRNAs make them potential therapeutic targets or biomarkers in various cancers.  \nEpigenetics refers to the change of gene expression level without changing gene sequence, which includes DNA methylation, chromosome remodeling, protein post-translational modification, histone modification, and ncRNA regulation [19] . In animal cells, proteins and RNAs have the greatest variety of modifications, and researchers have discovered a variety of modifications over the past 50 years [20] . Modification of proteins has been extensively characterized. Research on RNA modification has also increased in recent years. The disorder of RNA epigenetic pathway is related to the pathogenesis of human diseases, including cancer. Up to now, more than 170 different types of RNA modifications have been reported to modify different RNA types, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and lncRNA [21] . As one of the important epigenetic modifications, RNA methylation is closely related to the occurrence and development of cancer. It is expected to become a new target for cancer treatment. [22, 23] . Among this RNA methylation, the most well-studied one in recent years is N6-methyladenosine  \n1Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. 2Cell Therapy & Cell","cbCail5Ds4I1G2Zl","https://ap.wps.com/l/cbCail5Ds4I1G2Zl","pdf",3398714,15,"English","# Introduction\n## Long noncoding RNAs in cancer\n## Epigenetics and RNA modifications\n## m6A regulation and key components","[{\"question\":\"What roles do long noncoding RNAs play in cancer progression?\",\"answer\":\"Long noncoding RNAs regulate gene transcription, epigenetic states, RNA processing and stability, and influence signaling pathways related to tumor growth, apoptosis, and drug resistance.\"},{\"question\":\"How is RNA modification linked to the concept of epigenetics in cancer?\",\"answer\":\"RNA epigenetics involves changes in gene expression without altering DNA sequence, and RNA modifications—including methylation and other chemical edits—contribute to disease pathogenesis, including cancer.\"},{\"question\":\"How does m6A modification occur and why is it important?\",\"answer\":\"m6A is installed by “writers” (methylase complexes), removed by “erasers” (demethylases), and recognized by “readers.” This dynamic and reversible regulation affects RNA function and cancer progression.\"}]","Emerging role of RNA modification and long noncoding RNA interaction in cancer | PDF",1790002605,38]