[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332185-105":59,"doc-detail-332185-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-paradigms-unmasking-the-role-of-oxidative-stress-in-hpv-induced-carcinogenesis","Emerging paradigms - unmasking the role of oxidative stress in HPV-induced carcinogenesis","","The contribution of the human papillomavirus (HPV) to cancer is significant but not exclusive, as carcinogenesis involves complex mechanisms, notably oxidative stress. Oxidative stress and HPV can independently cause genome instability and DNA damage, contributing to tumorigenesis. Oxidative stress-induced DNA damage, especially double-strand breaks, aids in HPV integration into the host genome and promotes overexpression of E6 and E7. Lifestyle factors, genetic and epigenetic changes, and viral oncoproteins may shape oxidative stress and influence progression of HPV-related cancers. This review details mechanisms linking oxidative stress to HPV-mediated carcinogenesis, including mitochondrial alterations and increased ROS, antioxidant enzyme modulation (SOD, GSH, GPx), chronic inflammation, and PI3K/AKT/mTOR and ERK signaling activation. The review emphasizes controlling oxidative stress and proposes dietary antioxidants and ROS-targeted strategies as potential interventions to mitigate HPV-associated malignancies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-paradigms-unmasking-the-role-of-oxidative-stress-in-hpv-induced-carcinogenesis/332185/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-paradigms-unmasking-the-role-of-oxidative-stress-in-hpv-induced-carcinogenesis/332185.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do oxidative stress and HPV contribute to genome instability and DNA damage?","Question",{"text":112,"@type":113},"Oxidative stress and HPV can independently drive genome instability and DNA damage, promoting tumorigenesis. Oxidative stress-induced DNA damage, especially double-strand breaks, supports HPV integration into the host genome.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which HPV-related viral proteins are linked to oxidative stress-driven carcinogenesis?",{"text":117,"@type":113},"Oxidative stress facilitates HPV integration, which promotes the overexpression of the viral proteins E6 and E7. These proteins contribute to HPV oncogenic effects in carcinogenesis.",{"name":119,"@type":110,"acceptedAnswer":120},"What cellular pathways and processes are highlighted as mechanisms connecting oxidative stress to HPV-induced cancers?",{"text":121,"@type":113},"The review highlights increased ROS via altered mitochondrial morphology and function, changes in antioxidant enzymes such as SOD, GSH, and GPx, chronic inflammatory environments, and activation of signaling pathways including PI3K/AKT/mTOR and ERK.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332185,1790165576,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","Letafati etal. Infectious Agents and Cancer (2024) 19:30 Infectious Agents and Cancer  \n[https://doi.org/10.1186/s13027-024-00581-8](https://doi.org/10.1186/s13027-024-00581-8)  \n REVIEW Open Access  \nEmerging paradigms: unmasking    \nthe role of oxidative stress in HPV-induced carcinogenesis  \nArash Letafati 1,2†, Zahra Taghiabadi2†, Negar Zafarian2, Roxana Tajdini2, Mozhgan Mondeali2, Amir Aboofazeli2, Silvia Chichiarelli3, Luciano Saso4* and Seyed Mohammad Jazayeri1,2*  \nAbstract  \nThe contribution of the human papillomavirus (HPV) to cancer is significant but not exclusive, as carcinogenesis involves complex mechanisms, notably oxidative stress. Oxidative stress and HPV can independently cause genome instability and DNA damage, contributing to tumorigenesis. Oxidative stress-induced DNA damage, especially double-strand breaks, aids in the integration of HPV into the host genome and promotes the overexpression of two viral proteins, E6 and E7 . Lifestyle factors, including diet, smoking, alcohol, and psychological stress, along with genetic and epigenetic modifications, and viral oncoproteins may influence oxidative stress, impacting the progression of HPV-related cancers. This review highlights various mechanisms in oxidative-induced HPV-mediated carcinogenesis, including altered mitochondrial morphology and function leading to elevated ROS levels, modulation of antioxidant enzymes like Superoxide Dismutase (SOD), Glutathione (GSH), and Glutathione Peroxidase (GPx), induction of chronic inflammatory environments, and activation of specific cell signaling pathways like the Phosphoinositide 3-kinase, Protein kinase B, Mammalian target of rapamycin (PI3K/AKT/mTOR) and the Extracellular signal-regulated kinase (ERK) signaling pathway. The study highlights the significance of comprehending and controlling oxidative stress in preventing and treating cancer. We suggested that incorporating dietary antioxidants and targeting cancer cells through mechanisms involving ROS could be potential interventions to mitigate the impact of oxidative stress on HPV-related malignancies.  \nKeywords Oxidative stress, HPV-mediated carcinogenesis, Smoking, Alcohol, Psychological stress  \n†Arash Letafati and Zahra Taghiabadi have contributed equally.  \n*Correspondence:  \nLuciano Saso [luciano.saso@uniroma1.it](luciano.saso@uniroma1.it)[ ](luciano.saso@uniroma1.it)Seyed Mohammad Jazayeri [Jazayeri42@gmail.com](Jazayeri42@gmail.com)  \n1 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran  \n2 Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran  \n3 Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome, 00185 Rome, Italy  \n4 Department of Physiology and Pharmacology, Vittorio Erspamer”, Sapienza University, Rome, Italy  \nIntroduction  \nThe human papillomavirus (HPV), a virus with doublestranded DNA, has a high tendency to infect humans. HPV infections are common and typically clear up within 12–24 months [1] . Nevertheless, a minority of infected individuals may lead to cancer, accounting for nearly 4.5% of global cancer instances [2] . HPV has a particular tropism towards squamous epithelium cells [3] . Chronic infections with high-risk HPV strains, such as HPV-16, HPV-18, HPV-31, and HPV-33, could contribute to the malignancies [4] . HPV plays a major role in cervical, vaginal, vulvar, anal, and penile cancers. Furthermore, HPV is also linked to head and neck  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons ","cbCaif0EVr6Tmzth","https://ap.wps.com/l/cbCaif0EVr6Tmzth","pdf",2900619,21,"English","# Introduction\n## HPV and cancer risk\n## Reactive oxygen species and oxidative stress","[{\"question\":\"How do oxidative stress and HPV contribute to genome instability and DNA damage?\",\"answer\":\"Oxidative stress and HPV can independently drive genome instability and DNA damage, promoting tumorigenesis. Oxidative stress-induced DNA damage, especially double-strand breaks, supports HPV integration into the host genome.\"},{\"question\":\"Which HPV-related viral proteins are linked to oxidative stress-driven carcinogenesis?\",\"answer\":\"Oxidative stress facilitates HPV integration, which promotes the overexpression of the viral proteins E6 and E7. These proteins contribute to HPV oncogenic effects in carcinogenesis.\"},{\"question\":\"What cellular pathways and processes are highlighted as mechanisms connecting oxidative stress to HPV-induced cancers?\",\"answer\":\"The review highlights increased ROS via altered mitochondrial morphology and function, changes in antioxidant enzymes such as SOD, GSH, and GPx, chronic inflammatory environments, and activation of signaling pathways including PI3K/AKT/mTOR and ERK.\"}]","Emerging paradigms - unmasking the role of oxidative stress in HPV-induced carcinogenesis | PDF",1789997235,53]