[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372218-105":59,"doc-detail-372218-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","emerging-frontiers-in-colorectal-cancer-therapy-from-targeted-molecules-to-immunomodulatory-breakthroughs","Emerging Frontiers in Colorectal Cancer Therapy - From Targeted Molecules to Immunomodulatory Breakthroughs","","Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths globally, driving an urgent need for improved therapeutic strategies. Breakthrough modalities such as CAR-T cell therapies, oncolytic viruses, and immune checkpoint inhibitors are reshaping oncology through highly tailored approaches based on individual genetic and molecular profiles. This comprehensive review surveys recent clinical trials and advances across targeted molecular, immunomodulatory, and cell-based therapies. By weighing strengths, limitations, and potential synergies, it aims to advance personalized, effective CRC treatment and improve clinical outcomes for patients who have exhausted conventional options.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/emerging-frontiers-in-colorectal-cancer-therapy-from-targeted-molecules-to-immunomodulatory-breakthroughs/372218/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/emerging-frontiers-in-colorectal-cancer-therapy-from-targeted-molecules-to-immunomodulatory-breakthroughs/372218.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is colorectal cancer therapy an urgent research priority?","Question",{"text":112,"@type":113},"Colorectal cancer is the second leading cause of cancer-related deaths globally, creating a pressing need for therapeutic advancements.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which emerging therapies are highlighted for colorectal cancer treatment?",{"text":117,"@type":113},"The review emphasizes CAR-T cell therapies, oncolytic viruses, and immune checkpoint inhibitors as major transformative approaches.",{"name":119,"@type":110,"acceptedAnswer":120},"How does personalized treatment relate to these emerging CRC therapies?",{"text":121,"@type":113},"Therapies are tailored to individual genetic and molecular profiles, supporting a move toward precision medicine and potentially better patient outcomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372218,1790241415,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Digestive Diseases and Sciences (2025) 70:919–942 [https://doi.org/10.1007/s10620-024-08774-2](https://doi.org/10.1007/s10620-024-08774-2)  \nEmerging Frontiers in Colorectal Cancer Therapy: From Targeted Molecules to Immunomodulatory Breakthroughs and Cell‑Based Approaches  \nNayeralsadat Fatemi1 · Seyedeh Nasim Mirbahari1,2,3 · Sascha Tierling4 · Fatemeh Sanjabi5 · Shabnam Shahrivari5 · Mandana AmeliMojarad6 · Melika Amelimojarad6 · Meygol Mirzaei Rezaei7 · Parsa Nobaveh7 · Mehdi Totonchi1,3 · Ehsan Nazemalhosseini Mojarad8,9  \nReceived: 26 May 2024 / Accepted: 20 November 2024 / Published online: 27 January 2025 © The Author(s) 2025  \nAbstract  \nColorectal cancer (CRC) is ranked as the second leading cause of cancer-related deaths globally, necessitating urgent advancements in therapeutic approaches. The emergence of groundbreaking therapies, including chimeric antigen receptor-T (CAR-T) cell therapies, oncolytic viruses, and immune checkpoint inhibitors, marks a transformative era in oncology. These innovative modalities, tailored to individual genetic and molecular profiles, hold the promise of significantly enhancing patient outcomes. This comprehensive review explores the latest clinical trials and advancements, encompassing targeted molecular therapies, immunomodulatory agents, and cell-based therapies. By evaluating the strengths, limitations, and potential synergies of these approaches, this research aims to reshape the treatment landscape and improve clinical outcomes for CRC patients, offering new found hope for those who have exhausted conventional options. The culmination of this work is anticipated to pave the way for transformative clinical trials, ushering in a new era of personalized and effective CRC therapy.  \nKeywords Colorectal cancer · Targeted molecular therapies · CAR-T-cell therapies · Oncolytic viruses · Immune checkpoint inhibitors  \nIntroduction  \nColorectal cancer (CRC) is the second most common cause of cancer-related deaths globally [1] . The incidence is slightly higher in men and it peaks around the age of 50. Genetics, environmental, and lifestyle risk factors, all have  \na role in the development and progression of CRC [2] . The progression of tumors from benign early adenomas and polyps to malignant late-stage tumors is a complex and multifaceted process governed by intricate molecular signaling pathways. Two critical factors influencing this progression are microsatellite instability and chromosomal instability  \n*  \n1  \n2  \n3  \n4  \nEhsan Nazemalhosseini Mojarad  \n[Nazemalhosseini@sbmu.ac.ir](Nazemalhosseini@sbmu.ac.ir); [Ehsanmojarad@gmail.com](Ehsanmojarad@gmail.com)  \nBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \nDepartment of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran  \nDepartment of Genetics, Reproductive Biomedicine Research Center, ACECR, Royan Institute for Reproductive Biomedicine, Tehran, Iran  \nDepartment of Genetics/Epigenetics, Faculty NT, Life Sciences, Saarland University, Saarbrücken, Germany  \n5 Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical, Tehran, Iran  \n6 Department of Biology, Faculty of Basic Science, Kharrazi University, Tehran, Iran  \n7 School of Advanced Sciences and Technology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran  \n8 Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Yeman St, Chamran Expressway, P.O. Box 19857-17413, Tehran, Iran  \n9 Department of Surgery, Leiden University Medical Center, Leiden, Netherlands  \n(CIN) . Each of these factors plays a distinct role in tumor development [3]. Additionally, various gene mutations contribute to the tra","cbCaiaRVk8pSyVJf","https://ap.wps.com/l/cbCaiaRVk8pSyVJf","pdf",1982601,24,"English","# Abstract\n# Introduction","[{\"question\":\"Why is colorectal cancer therapy an urgent research priority?\",\"answer\":\"Colorectal cancer is the second leading cause of cancer-related deaths globally, creating a pressing need for therapeutic advancements.\"},{\"question\":\"Which emerging therapies are highlighted for colorectal cancer treatment?\",\"answer\":\"The review emphasizes CAR-T cell therapies, oncolytic viruses, and immune checkpoint inhibitors as major transformative approaches.\"},{\"question\":\"How does personalized treatment relate to these emerging CRC therapies?\",\"answer\":\"Therapies are tailored to individual genetic and molecular profiles, supporting a move toward precision medicine and potentially better patient outcomes.\"}]","Emerging Frontiers in Colorectal Cancer Therapy - From Targeted Molecules to Immunomodulatory Breakthroughs | PDF",1790194006]