[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384720-105":59,"doc-detail-384720-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","elimination-of-reserve-cells-for-prevention-of-hpv-associated-cervical-cancer","Elimination of reserve cells for prevention of HPV-associated cervical cancer","","Human papilloma viruses (HPV) drive most squamous cell cervical cancers (SCC) through early genes E6 and E7, which can transform normal squamous epithelium into malignancy. A controversy has persisted over which cells are central to cervical carcinogenesis. This review explains that SCC commonly arise after HPV infection of immature squamous metaplasia, followed by reserve cell hyperplasia, and discusses intervention strategies aligned with the WHO goal to eliminate HPV-associated cervical cancer.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/elimination-of-reserve-cells-for-prevention-of-hpv-associated-cervical-cancer/384720/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/elimination-of-reserve-cells-for-prevention-of-hpv-associated-cervical-cancer/384720.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role do HPV early genes E6 and E7 play in cervical cancer development?","Question",{"text":113,"@type":114},"E6 and E7 can transform normal squamous epithelium into cancer by immortalizing cells, supporting the malignant progression described in the review.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why does the stratified squamous epithelium model fall short for cervical carcinogenesis?",{"text":118,"@type":114},"The review notes that most cervical SCC originate in endocervical columnar epithelium undergoing squamous metaplasia, whereas the stratified squamous model does not reflect this origin context.",{"name":120,"@type":111,"acceptedAnswer":121},"How are reserve cells implicated in the pathway leading to SCC?",{"text":122,"@type":114},"The text explains that SCC develop after HPV infection of immature squamous metaplasia, with proliferating reserve cells/reserve cell hyperplasia contributing to the carcinogenic process.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},384720,1790457879,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Virus Research 329 (2023) 199068  \nContents lists available at ScienceDirect  \nVirus Research  \njournal [homepage:](homepage: www.elsevier.com/locate/virusres)[ www.elsevier.com/locate/virusres](homepage: www.elsevier.com/locate/virusres)  \n| Elimination of reserve cells for prevention of HPV-associated cervical cancer |  |  | |\n| --- | --- | --- | --- |\n| Olaf Reich a, *, Sigrid Regauerb\u003Cbr>a Department of Obstetrics & Gynecology , Medical University of Graz, Graz, Austria b Diagnostic & Research Institute of Pathology, Medical University of Graz, Graz, Austria |  |  |  |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords: HPV\u003Cbr>HPV research model Reserve cells Cervical carcinogenesis Treatment\u003Cbr>Recurrent disease Prevention |  | Human papilloma viruses (HPV), that are causative for most squamous cell cervical cancers (SCC), have a simple structure with only a few genes (six early and two late genes). Two of the early HPV genes (E6 and E7) are capable of transforming normal squamous epithelium into cancer. In the last 10 years, a controversial discussion arose as to which cells are primarily involved in cervical carcinogenesis. Virologists traditionally use a research model of stratified squamous epithelium, a permissive environment for completion of a full HPV-life cycle. Basic insights on HPV tropism, HPV life cycle, HPV-uptake, HPV-replication, HPV-gene expression were gained from this model. Stratified squamous epithelium, however, is a low-risk area for SCC. Most SCC develop in an area of endocervical columnar epithelium that undergoes squamous metaplasia. SCC arise after infection of immature squamous metaplasia, proliferating reserve cells/reserve cell hyperplasia and reserve cells of the endocervical columnar epithelium. Study models investigating this pathway of carcinogenesis do not exist and therapeutic consequences deduced from this knowledge are lacking. This review describes in detail cervical carcinogenesis after HPV infection of subcolumnar reserve cells and discusses new intervention strategies for patients. The WHO-launched global strategy to eliminate HPV-associated cervical cancer builds primarily on prophylactic vaccination, screening and treatment. New insights in cervical pathogenesis, may assist in reaching this ambitious WHO goal. |  |\n\n1. Introduction  \nHuman papilloma viruses (HPV) are small DNA viruses that replicate in specific anatomical sites. They have a simple structure and are built of only a few genes (six early and two late genes). The late genes (L1 and L2) encode the major capsid proteins. The early genes (E6, E7, E1, E2, E4, E5) are involved in replication control. Two of the early HPV genes (E6 and E7) are able to transform normal squamous epithelium into cancer due to their ability to immortalize cells. Virologists traditionally use a research model of stratified squamous epithelium, a permissive environment for completion of the HPV-life cycle. Basic insights on HPV associated disease including viral tropism, viral life cycle, HPV-uptake, HPV-replication, HPV-gene expression, the concept of transforming HPV infection in the development of HPV-associated squamous cell cancers (SCC) and immune control of HPV-infection are based on a study model consisting of this stratified squamous epithelium.  \nIn fact, this “stratified squamous epithelium model” is suitable for  \nresearch on HPV-associated carcinogenesis in stratrified squamousepithelium of the skin, penis, vulva, vagina, and oral cavity. By contrast, this model has short comings when explaining cervical carcinogenesis, because most cervical SCC originate in an area initially covered by nonsquamous endocervical epithelium consisting of tall columnar epithelium with subcolumnar reserve cells capable of squamous metaplasia. The area in which most cervical SCC develop is called transformation zone, and features several maturation levels of metaplastic squamousepithelium bordering tall columnar epithelium with subcolumnar epi","cbCaiglft8PZ7a3z","https://ap.wps.com/l/cbCaiglft8PZ7a3z","pdf",1162709,"English","# Introduction\n## HPV biology and traditional stratified squamous epithelium model\n## Transformation zone and reserve-cell pathway in cervical carcinogenesis","[{\"question\":\"What role do HPV early genes E6 and E7 play in cervical cancer development?\",\"answer\":\"E6 and E7 can transform normal squamous epithelium into cancer by immortalizing cells, supporting the malignant progression described in the review.\"},{\"question\":\"Why does the stratified squamous epithelium model fall short for cervical carcinogenesis?\",\"answer\":\"The review notes that most cervical SCC originate in endocervical columnar epithelium undergoing squamous metaplasia, whereas the stratified squamous model does not reflect this origin context.\"},{\"question\":\"How are reserve cells implicated in the pathway leading to SCC?\",\"answer\":\"The text explains that SCC develop after HPV infection of immature squamous metaplasia, with proliferating reserve cells/reserve cell hyperplasia contributing to the carcinogenic process.\"}]","Elimination of reserve cells for prevention of HPV-associated cervical cancer | PDF",1790264684,15]