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Correlations between TUBA1C expression and patients’ clinical characteristics are tested using Wilcoxon signed-rank, Kruskal-Wallis, and logistic regression analyses. Survival impacts are assessed through Kaplan–Meier, Cox regression, and Kaplan–Meier plotter, while Gene Set Enrichment Analysis (GSEA) links high-expression phenotypes to multiple signaling pathways. High TUBA1C indicates poorer overall survival and recurrence- and metastasis-free survival.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/elevated-expression-of-tuba1c-in-breast-cancer-predicts-poor-prognosis/383113/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/elevated-expression-of-tuba1c-in-breast-cancer-predicts-poor-prognosis/383113.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What dataset and analyses are used to evaluate TUBA1C in breast cancer?","Question",{"text":113,"@type":114},"TUBA1C gene expression profiles are extracted from TCGA. Prognostic value is assessed using statistical correlation tests, survival analyses, and Gene Set Enrichment Analysis (GSEA).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does high TUBA1C expression relate to patient outcomes?",{"text":118,"@type":114},"High TUBA1C expression is associated with poorer survival time and worse outcomes, including overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS).",{"name":120,"@type":111,"acceptedAnswer":121},"Is TUBA1C an independent prognostic factor?",{"text":122,"@type":114},"Univariate and multivariate Cox regression analyses indicate that TUBA1C is an independent prognostic factor for OS in breast cancer patients.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383113,1790342538,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","PLOS ONE  \nOPEN ACCESS  \nCitation: Zhao Y, Wang W, Li J, Du J, Xie Q, Wang M, et al. (2023) Elevated expression of TUBA1C in breast cancer predicts poor prognosis. PLoS ONE 18(11): e0263710 . [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). pone.0263710  \nEditor: Suhwan Chang, University of Ulsan College  \nof Medicine, REPUBLIC OF KOREA Received: March 15, 2021  \nAccepted: May 15, 2022  \nPublished: November 30, 2023  \nPeer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:  \n[https://doi.org/10.1371/journal.pone.0263710](https://doi.org/10.1371/journal.pone.0263710)  \n[Copyright:](Copyright:) © [2023 Zhao et al](2023 Zhao et al). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: We have performed the upload of the minimum dataset according to  \nthe PLOS ONE journal’s request for our manuscript, which we uploaded at the following website address: [https://datadryad.org/stash/](https://datadryad.org/stash/)  \nRESEARCH ARTICLE  \nElevated expression of TUBA1C in breast cancer predicts poor prognosis  \nYi Zhao1☯, Wenwen Wang1,2☯, Jinming Li1,3☯, Jiarui Du1, Qiqi Xie1, Miaozhou Wang1, Zhen Liu1, Xingfa Huo1, Fuxing Zhao1, Dengfeng Ren1, Jiuda Zhao1 *, GuoShuang Shen1 *  \n1 Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, QingHai, China, 2 Department of Pharmacogenomics, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, Shaanxi, China, 3 Graduate School of Qinghai University, Xining, QingHai, China  \n☯ These authors contributed equally to this work.  \n* [jiudazhao0519@163.com](jiudazhao0519@163.com) (JZ); [guoshuangshen6688@163.com](guoshuangshen6688@163.com) (GSS)  \nAbstract  \nα1C-tubulin (TUBA1C) is a member of the α-tubulin family and has served as a potential biomarker in a variety of cancers in many studies. In this study, the gene expression profile of TUBA1Cin The Cancer Genome Atlas (TCGA) was extracted for analysis, and the prognostic value of TUBA1Cin breast cancer was comprehensively evaluated. The Wilcoxon signed-rank test, Kruskal-Wallis test, and logistic regression analysis were performed to confirm the correlations between TUBA1C expression and the clinical characteristics of breast cancer patients. The effect of TUBA1C expression on the survival of breast cancer patients was assessed by Kaplan-Meier curve, Cox regression analysis, and the KaplanMeier plotter (an online database) . The TCGA data set was used for the Gene Set Enrichment Analysis (GSEA) . The results confirmed that high TUBA1C expression in breast cancer was closely correlated with survival time, survival status, and tumor size. In addition, elevated TUBA1C expression can predict poor overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS) . Univariate and multivariate analyses (Cox regression analyses) confirmed that TUBA1Cwas an independent prognostic factor for the OS of breast cancer patients. The GSEA identified that the high TUBA1C expression phenotype was differentially enriched in cell cycle, basal transcription factor, P53 signaling pathway, pathways in cancer, TOLL-like receptor signaling pathway, and NOD-like receptor signaling pathway. In summary, high messenger RNA (mRNA) expression of TUBA1C is an independent risk factor for poor prognosis of breast cancer.  \nBackground  \nBreast cancer is a common malignancy in women worldwide, as new breast cancer cases account for 11 .67% of all new cancer cases each year, an","cbCaivBB4w6BFldt","https://ap.wps.com/l/cbCaivBB4w6BFldt","pdf",2308004,13,"English","# Abstract\n# Background\n## Clinical burden of breast cancer\n## Need for improved prognostic indicators\n## Role of microtubules and tubulin subtypes","[{\"question\":\"What dataset and analyses are used to evaluate TUBA1C in breast cancer?\",\"answer\":\"TUBA1C gene expression profiles are extracted from TCGA. Prognostic value is assessed using statistical correlation tests, survival analyses, and Gene Set Enrichment Analysis (GSEA).\"},{\"question\":\"How does high TUBA1C expression relate to patient outcomes?\",\"answer\":\"High TUBA1C expression is associated with poorer survival time and worse outcomes, including overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS).\"},{\"question\":\"Is TUBA1C an independent prognostic factor?\",\"answer\":\"Univariate and multivariate Cox regression analyses indicate that TUBA1C is an independent prognostic factor for OS in breast cancer patients.\"}]","Elevated expression of TUBA1C in breast cancer predicts poor prognosis | PDF",1790254286,33]