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Breast cancer tissues and matched adjacent normal tissues from 113 adult patients were analyzed by immunohistochemistry for CCL20 and EMT markers (E-cadherin, vimentin, N-cadherin), with clinicopathologic associations tested using chi-squared and Spearman analyses. Survival endpoints were assessed by Kaplan-Meier, and independent effects quantified with Cox regression. Results show stronger cytoplasmic CCL20 in tumors, correlations with tumor size, ER status, Ki67, vascular invasion, stage, and significant association with EMT markers.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/elevated-ccl20-expression-was-associated-with-poor-prognosis-for-breast-cancer/433673/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/elevated-ccl20-expression-was-associated-with-poor-prognosis-for-breast-cancer/433673.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How was CCL20 expression measured in this study?","Question",{"text":113,"@type":114},"Breast cancer and matched adjacent normal tissues from 113 patients were collected and analyzed using immunohistochemical staining for CCL20 along with EMT-related markers (E-cadherin, vimentin, N-cadherin).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What did the results show about CCL20 in breast cancer vs normal tissue?",{"text":118,"@type":114},"Cytoplasmic CCL20 expression was stronger in cancer tissues than in normal tissue, and it correlated with multiple clinicopathological features including tumor size, ER status, Ki67, vascular invasion, and TNM stage.",{"name":120,"@type":111,"acceptedAnswer":121},"Is elevated CCL20 an independent predictor of survival?",{"text":122,"@type":114},"Yes. CCL20 expression was an independent prognostic predictor for overall survival in Cox proportional hazards modeling, with a reported hazard ratio and statistical significance.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},433673,1790895278,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Chin MedAssoc  \nOriginal article  \nElevated CCL20 expression was associated with poor prognosis for breast cancer  \nXia Zhaoa,*, Yanping Lia, Yu Fenga, Shuzhen Lva  \naDepartment of Medical Oncology, Department of Surgical Breast Cancer, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China  \nAbstract  \nBackground: The chemokine (C-C motif) ligand 20 (CCL20) exhibits pronounced expression within tumor cells, effectively facilitating tumor progression by modulating the immunosuppressive microenvironment and promoting tumor cell aggressiveness. Methods: Breast cancer and matched adjacent normal tissues from 113 adult breast cancer patients were collected for immunohistochemical staining of CCL20, E-cadherin, vimentin, and N-cadherin. The assessment evaluated the association between CCL20 expression and clinicopathological factors using Pearson chi-squared test, epithelial-mesenchymal transition (EMT) markers expression using Spearman’s rank correlation test, both OS and DFS using Kaplan-Meier survival analysis, and Cox proportional hazards regression modeling.  \nResults: Cytoplasmic CCL20 expression was stronger in cancer tissues, compared to normal tissue (69 .9% vs 23%) . Strong correlations were observed between CCL20 expression and many clinicopathological features, including tumor size (p = 0.000), estrogen receptor (ER) status (p = 0.003), Ki67 status (p = 0.000), vascular invasion (p = 0.001), and tumor-node-metastasis stage (p = 0.001) . Additionally, CCL20 expression was an independent prognostic predictor for overall survival (OS) (hazard ratio [HR], 3.207; 95% CI, 1.142-9.005, p = 0 .027) . Furthermore, a significant association between CCL20 expression and EMT markers was observed. CCL20 expression was linked to unfavorable outcomes in all patients (p = 0.000), ER-positive patients (p = 0.001), and node-positive/negative (p = 0.005/0 .001) subgroups.  \nConclusion: These findings highlighted that elevated CCL20 expression was linked to a more aggressive tumor phenotype and a disappointing OS in breast cancer patients, thus advocating for the consideration of CCL20 expression being a novel independent prognostic biomarker for guiding bespoke treatment strategies.  \nKeywords: Breast cancer; CCL20; EMT markers; Prognosis  \nLay Summary: The protein chemokine (C-C motif) ligand 20 (CCL20) facilitates tumor progression by directly functioning on tumor cells to promote the aggressiveness. In this study, patient tumor samples and paired normal tissues were used to investigate the relationship between the amount of CCL20 and the aggressiveness of breast cancer. The data showed that (1) CCL20 is highly produced in cancer tissues compared to normal tissues; (2) the level of CCL20 is associated with tumor size, tumor cell proliferation, vascular invasion of tumor cells, and stage of metastasis to node; (3) CCL20 expression is significantly linked to unfavorable outcomes in breast cancer patients. These findings highlighted that elevated CCL20 production was linked to a more aggressive tumor status and a disappointing survival in breast cancer patients, thus prompting the consideration of CCL20 expression guiding bespoke treatment strategies.  \n*Address correspondence. Dr. Xia Zhao, Department of Surgical Breast Cancer, Capital Medical University Cancer Center, Beijing Shijitan Hospital, 10 Tieyi Road, Beijing 100038, China. E-mail address: [136healthy@sina.com](136healthy@sina.com) (X. Zhao).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2025) 88: 469-480.  \nReceived June 19, 2024; accepted January 1, 2025. doi: 10. 1097/JCMA.0000000000001233  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/li","cbCaiqKBqluGLx2W","https://ap.wps.com/l/cbCaiqKBqluGLx2W","pdf",1408187,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"How was CCL20 expression measured in this study?\",\"answer\":\"Breast cancer and matched adjacent normal tissues from 113 patients were collected and analyzed using immunohistochemical staining for CCL20 along with EMT-related markers (E-cadherin, vimentin, N-cadherin).\"},{\"question\":\"What did the results show about CCL20 in breast cancer vs normal tissue?\",\"answer\":\"Cytoplasmic CCL20 expression was stronger in cancer tissues than in normal tissue, and it correlated with multiple clinicopathological features including tumor size, ER status, Ki67, vascular invasion, and TNM stage.\"},{\"question\":\"Is elevated CCL20 an independent predictor of survival?\",\"answer\":\"Yes. CCL20 expression was an independent prognostic predictor for overall survival in Cox proportional hazards modeling, with a reported hazard ratio and statistical significance.\"}]","Elevated CCL20 expression was associated with poor prognosis for breast cancer | PDF",1790665051]