[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-444771-105":59,"doc-detail-444771-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","elastokines-are-associated-with-a-poor-prognosis-in-idiopathic-pulmonary-fibrosis-key-findings-on-disease-severity-and-survival","Elastokines are Associated with a Poor Prognosis in Idiopathic Pulmonary Fibrosis - Key Findings on Disease Severity and Survival","","Elastokines, elastin degradation products released during idiopathic pulmonary fibrosis (IPF) remodeling, were evaluated as potential biomarkers of disease severity and clinical outcome. Elastokine concentrations were measured by ELISA in samples from an interstitial lung disease registry (n=81 IPF, n=24 healthy volunteers). Linear and logistic regression assessed associations with diagnosis-time levels, lung function, and transplant-free survival. Higher elastokines correlated with worse lung function and decreased three-year transplant-free survival, suggesting matrix turnover markers linked to clinically relevant outcomes in IPF.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/elastokines-are-associated-with-a-poor-prognosis-in-idiopathic-pulmonary-fibrosis-key-findings-on-disease-severity-and-survival/444771/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/elastokines-are-associated-with-a-poor-prognosis-in-idiopathic-pulmonary-fibrosis-key-findings-on-disease-severity-and-survival/444771.png","ImageObject",300,407,{"name":92,"@type":93},"Anna Hans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What are elastokines in the context of IPF?","Question",{"text":113,"@type":114},"Elastokines are elastin degradation products (EDPs) released when elastin is broken down during IPF extracellular matrix remodeling, detectable in body fluids such as urine, plasma, and bronchoalveolar lavage fluid.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were elastokine concentrations measured and analyzed?",{"text":118,"@type":114},"Elastokine concentrations were measured using ELISA, using samples from a single institution’s interstitial lung disease registry/biorepository. Linear and logistic regression were used to test associations with lung function and clinical outcomes.",{"name":120,"@type":111,"acceptedAnswer":121},"What clinical outcomes were associated with higher elastokine levels?",{"text":122,"@type":114},"Higher elastokine concentrations were linked to reduced forced vital capacity (FVC) and decreased three-year transplant-free survival in patients with IPF.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},444771,1791092215,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","University of Rochester Medical Center  \nUniversity of Rochester Medical Center  \nUniversity of Rochester Medical Center  \nUniversity of Rochester Medical Center  \nVirginia Commonwealth University  \nUniversity of Rochester Medical Center  \nUniversity of Rochester Medical Center  \npulmonary «brosis, elastokines, elastin degradation products, extracellular matrix remodeling, and transplant-free survival  \n December 30th, 2025  \n [https://doi.org/10.21203/rs.3.rs-7881084/v1](https://doi.org/10.21203/rs.3.rs-7881084/v1)  \n 􀁱 􀅏 This work is licensed under a Creative Commons Attribution 4.0 International License.  \nRead Full License  \n No competing interests reported.  \nDuring the development of idiopathic pulmonary «brosis (IPF), elastin is broken down and replaced with a stiffer substrate which interferes with normal breathing. This remodeling releases elastin degradation products (EDPs), or elastokines, which can then be measured. We examined the association between elastokine concentrations and disease severity to determine if EDP concentrations are associated with clinically relevant markers in IPF.  \nConcentrations of elastokines were measured via enzyme linked immunosorbent assay (ELISA) . Samples were obtained from a single institution’s Interstitial Lung Disease (ILD) registry/biorepository (n = 81 with IPF and 24 healthy volunteers) . We used linear and logistic regression modeling to assess the association between EDP concentrations at the time of diagnosis, lung function, and clinical outcomes.  \nPatients with IPF were older, more likely to be male, had ever smoked, and had worse lung function compared to healthy volunteers (p value ≤ 0.02 for all parameters) . Patients with IPF had higher concentrations of elasotkines (p \u003C 0 .001), and the highest elastokine concentrations were associated with reduced forced vital capacity (FVC, p = 0 .026), and decreased three-year transplant-free survival (p = 0.0005) . These «ndings suggest that elastokines are biomarkers of matrix turnover and are associated with relevant clinical outcomes in patients with IPF.  \nIdiopathic pulmonary «brosis (IPF) is a disease of unknown cause marked by progressive scarring of the lung occurring almost exclusively occurs in older adults. As the world’s population ages, its incidence and prevalence are on the rise(1) . The mechanisms by which IPF develops remain incompletely understood, but it is thought that an injury occurs to airway epithelial cells, leading to «broblast activation/differentiation, and lung scarring. IPF carries a prognosis only slightly better than lung cancer(2) . Currently, there are two FDA-approved medications for the treatment of IPF: nintedanib (a triple kinase receptor inhibitor)(3) and pirfenidone (a partial TGF-β antagnoist)(4) . While these medications decrease the rate of decline in FVC and reduce respiratory related hospitalizations, they do not reverse established «brosis and are often not well-tolerated. The only cure for IPF is lung transplantation( 5) . However, lung transplant survival rates are the lowest among solid organ transplants; the median survival rate after lung transplantation is 5.8 years( 6) .  \nElastin is a hydrophobic polymer that provides tissue resilience, elasticity, and stability that is essential for proper lung function. During the development of IPF, pro-«brotic cytokines, like transforming growth factor-beta (TGF-β), induce the activity of elastases and proteinases, which degrade mature elastin, and are increased in the lung tissue of patients with IPF(7) . Elastin is synthesized as tropoelastin by «broblasts, smooth muscle cells, endothelial cells, and chondrocytes(8) and is subsequently condensed to mature elastin in the extracellular space. Mature elastin is a polymer of cross-linked tropoelastin «brils made of glycoproteins such as latent transforming growth factor β-binding proteins (LTBPs), «brillin-1 and − 2, and micro«brillar-associated proteins (MFAPs)(9) . In healthy adult tissues","cbCaidac1ps4xX5i","https://ap.wps.com/l/cbCaidac1ps4xX5i","pdf",1373502,18,"English","# Background\n## IPF remodeling and elastin degradation\n## Elastokines as measurable products\n# Study Methods\n## Cohort and sample source\n## ELISA measurement and statistical modeling\n# Results\n## Patient characteristics\n## Associations with lung function and survival\n# Conclusion","[{\"question\":\"What are elastokines in the context of IPF?\",\"answer\":\"Elastokines are elastin degradation products (EDPs) released when elastin is broken down during IPF extracellular matrix remodeling, detectable in body fluids such as urine, plasma, and bronchoalveolar lavage fluid.\"},{\"question\":\"How were elastokine concentrations measured and analyzed?\",\"answer\":\"Elastokine concentrations were measured using ELISA, using samples from a single institution’s interstitial lung disease registry/biorepository. Linear and logistic regression were used to test associations with lung function and clinical outcomes.\"},{\"question\":\"What clinical outcomes were associated with higher elastokine levels?\",\"answer\":\"Higher elastokine concentrations were linked to reduced forced vital capacity (FVC) and decreased three-year transplant-free survival in patients with IPF.\"}]","Elastokines are Associated with a Poor Prognosis in Idiopathic Pulmonary Fibrosis - Key Findings on Disease Severity and Survival | PDF",1790709229,45]