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Thirty-five participants were randomly assigned to exercise or control. Treadmill training occurred at 55% of maximal oxygen consumption with workload progression, while dual-energy x-ray absorptiometry and repeated blood sampling measured TNF-α, C-reactive protein, adiponectin, TAS, and 8-OHdG. After 8 weeks, the exercise group showed reduced body fat percentage, TNF-α, and 8-OHdG with increased TAS, and at week 4 TNF-α fell while TAS rose even without measurable weight or fat-mass changes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/eight-weeks-of-moderate-aerobic-exercise-on-body-composition-and-markers-of-inflammation-and-oxidative-stress-in-middle-aged-obese-females/434005/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/eight-weeks-of-moderate-aerobic-exercise-on-body-composition-and-markers-of-inflammation-and-oxidative-stress-in-middle-aged-obese-females/434005.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was the exercise intervention delivered in the study?","Question",{"text":112,"@type":113},"Participants in the exercise group performed treadmill-based aerobic training at 55% of maximal oxygen consumption, with a fixed workload adjusted for body mass and progression from three to four weekly sessions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which biomarkers were measured to evaluate inflammation and oxidative stress?",{"text":117,"@type":113},"Blood samples were collected at baseline, 4 weeks, and 8 weeks to analyze TNF-α, C-reactive protein, adiponectin, total antioxidant status (TAS), and 8-hydroxydeoxyguanosine (8-OHdG).",{"name":119,"@type":110,"acceptedAnswer":120},"What changes occurred by week 4 and what does that imply?",{"text":121,"@type":113},"By week 4, TNF-α decreased and TAS increased without measurable changes in body weight or fat mass, indicating an early anti-inflammatory and antioxidative response independent of adiposity reduction.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},434005,1790729986,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Original Article  \n[https://doi.org/10.12965/jer.2550690.345](https://doi.org/10.12965/jer.2550690.345) Journal of Exercise Rehabilitation 2025;21(6):284-291  \nEight weeks of moderate aerobic exercise on body composition and markers of inflammation and oxidative stress in middle-aged obese females  \nKyung-Shin Park1,*, Paola Canales Gonzalez1, Miguel Nieto1, Brett S. Nickerson2  \n1Department of Health Sciences, College of Nursing and Health Sciences, Texas A&M International University, Laredo, TX, USA 2School of Health and Rehabilitation Sciences, Ohio State University, Columbus, OH, USA  \nThis study investigated the effects of 4-week and 8-week moderate-intensity aerobic exercise on body composition and markers of inflammation and oxidative stress in middle-aged obese Hispanic females, with a particular focus on assessing these changes independently of fat mass reduction. A total of 35 participants were randomly assigned to either an exercise group or a control group for an eight-week intervention. The exercise group performed treadmill-based aerobic training at 55% of maximal oxygen consumption, with a fixed workload adjusted for body mass and a progression from three to four weekly sessions. Body composition was assessed using dual-energy x-ray absorptiometry, and blood samples were collected at baseline, 4 weeks, and 8 weeks to analyze tumor necrosis factor-alpha (TNF-α), C-reactive protein, adiponectin, total antioxidant status (TAS), and 8-hydroxydeoxyguanosine (8-OHdG). After 8 weeks, the exercise group showed significant reduc-  \ntions in body fat percentage, TNF-α, and 8-OHdG, alongside an increase inTAS. Notably, by week 4, significant decreases inTNF-α and increases in TAS were observed despite no measurable changes in body weight or fat mass, indicating an early anti-inflammatory and antioxidative response to exercise independent of adiposity reduction. The findings at 4 weeks suggest that moderate aerobic exercise can independently reduce inflammation and oxidative stress, even before measurable fat loss occurs. These improvements were further enhanced by fat loss after 8 weeks, indicating that moderate aerobic exercise may reduce the risk of obesity-related disorders in middle-aged obese females, both through direct anti-inflammatory effects and by promoting fat loss.  \nKeywords: Inflammation, Oxidative stress, Obesity, Aerobic exercise, Middle-aged women  \nINTRODUCTION  \nObesity has emerged as a major global public health concern, reaching pandemic levels over the past two decades (Abd El-Kader et al., 2013; Khanna et al., 2022) . In the United States, the Hispanic population bears a disproportionately higher prevalence of obesity compared to White Caucasians (Howell et al., 2022), placing this group at increased risk for obesity-related metabolic complications. Beyond its impact on body weight, obesity contributes to broader health disparities due to its strong association with cardiometabolic disorders and reduced quality of life (Ellulu et al., 2017; Khanna et al., 2022).  \nExcess body fat plays an active role in disease progression by  \nfunctioning as an endocrine organ that elevates circulating proinflammatory cytokines and oxidative stress (Beavers et al., 2015; Khanna et al., 2022). These biological disturbances are implicated in the pathogenesis of insulin resistance, cardiovascular disease, and other obesity-related conditions (Ellulu et al., 2017). As a result, inflammation and oxidative stress are recognized as key therapeutic targets in lifestyle interventions aimed at mitigating disease risk in obese individuals (Krause et al., 2014; Papagianni et al., 2023; You et al., 2004).  \nAerobic exercise is a widely recognized strategy for preventing and managing chronic diseases. Numerous studies have shown that regular aerobic training can reduce cardiovascular risk factors and improve insulin sensitivity (Balducci et al., 2010; Beavers et  \n*Corresponding author: Kyung-Shin Park  [https://orcid.org/0000-0","cbCaitDPnNlAIZ06","https://ap.wps.com/l/cbCaitDPnNlAIZ06","pdf",329648,"English","# Introduction\n## Obesity as a public health concern\n## Inflammation and oxidative stress in obesity\n## Aerobic exercise and metabolic benefits\n## Exercise effects independent of fat loss","[{\"question\":\"How was the exercise intervention delivered in the study?\",\"answer\":\"Participants in the exercise group performed treadmill-based aerobic training at 55% of maximal oxygen consumption, with a fixed workload adjusted for body mass and progression from three to four weekly sessions.\"},{\"question\":\"Which biomarkers were measured to evaluate inflammation and oxidative stress?\",\"answer\":\"Blood samples were collected at baseline, 4 weeks, and 8 weeks to analyze TNF-α, C-reactive protein, adiponectin, total antioxidant status (TAS), and 8-hydroxydeoxyguanosine (8-OHdG).\"},{\"question\":\"What changes occurred by week 4 and what does that imply?\",\"answer\":\"By week 4, TNF-α decreased and TAS increased without measurable changes in body weight or fat mass, indicating an early anti-inflammatory and antioxidative response independent of adiposity reduction.\"}]","Eight weeks of moderate aerobic exercise on body composition and markers of inflammation and oxidative stress in middle-aged obese females | PDF",1790666535]