[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-445772-105":59,"doc-detail-445772-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","efficacy-and-safety-of-therapeutic-strategies-for-human-brucellosis-a-systematic-review-and-network-metaanalysis","Efficacy And Safety Of Therapeutic Strategies For Human Brucellosis: A Systematic Review And Network MetaAnalysis","","Poster abstracts present evidence-focused research on two major healthcare topics: ovarian cancer’s potential life lost and indirect costs in Brazil, and the effectiveness and safety of comprehensive gender reassignment surgery approaches. The ovarian cancer study uses SUS data (2014–2023) to estimate years of potential life lost and productivity costs from national life expectancy and GDP inputs. The systematic review evaluates integrated and equitable models for access to gender reassignment surgery using a rapid umbrella review method. Collectively, results address clinical outcomes, burdens, and equity considerations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/efficacy-and-safety-of-therapeutic-strategies-for-human-brucellosis-a-systematic-review-and-network-metaanalysis/445772/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/efficacy-and-safety-of-therapeutic-strategies-for-human-brucellosis-a-systematic-review-and-network-metaanalysis/445772.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the objective of the ovarian cancer study in Brazil?","Question",{"text":112,"@type":113},"To describe the patient profile with ovarian cancer and estimate the indirect costs within the Brazilian Unified Health System (SUS).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was indirect cost estimated for ovarian cancer patients?",{"text":117,"@type":113},"Years of potential life lost (YPLL) were calculated using a Brazilian life expectancy of 79 years, with a productivity threshold of 62 years, and productivity loss costs were converted using GDP per capita values.",{"name":119,"@type":110,"acceptedAnswer":120},"What approach was used to evaluate evidence for gender reassignment surgery?",{"text":121,"@type":113},"A rapid umbrella review methodology using Web of Science and MEDLINE, prioritizing clinical trials and systematic reviews, to assess outcomes within integrated care models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},445772,1790797182,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","S56 Poster Presentations (online)  \nPD41 Potential Life Lost And Indirect Costs Of Ovarian Cancer For Patients In Brazil: A RealWorld Study  \nPamela Santana ([pamela.santana@astrazeneca.com](pamela.santana@astrazeneca.com)), Eduardo Paulino and Flávia Lopes  \nIntroduction: Ovarian cancer (OC) is the most lethal gynecological tumor worldwide. This study aimed to describe the profile of patients with OC and estimate the indirect costs of OC within the Brazilian Unified Health System (SUS) .  \nMethods: This retrospective observational study used data from the Department of Informatics of the SUS and included patients aged 18 years or older with at least one record of International Classification of Diseases, 10th Revision code C56 from 2014 to 2023 . Indirect costs were estimated by calculating years of potential life lost (YPLL) based on a 2022 life expectancy of 79 years for Brazilian women. The age threshold of years of potential productivity lost (YPPLL) was set at 62 years. The cost of productivity loss (CPL) was calculated using the gross domestic product (GDP) per capita in USD from the World Bank, converted to BRL (USD1=BRL5 .66) .  \nResults: The study included a total of 36,141 patients with OC, with an average age of 56.1 years (standard deviation 13.4) at the time of their first claim. Most of the patients (51.2%) were white, lived in the southeast region of Brazil (44.6%), and had their first claim at advanced cancer stages (78.1%) . The estimated indirect costs for OC were 22.1 YPLL per patient. The estimated YPPLL was 7.3 years, and the CPL was USD65,705.30 (BRL374,040.56) per patient. Conclusions: This study provided valuable insights into the profile and indirect costs of OC. By analyzing real-world data, we highlighted the burden of OC, which impacts not only the health and longevity of patients but also places a significant financial burden on society due to productivity losses.  \nPD42 Systematic Review Of The Comprehensive Approach To Gender Reassignment Surgery  \nSantiago Torales ([santiago.torales@gmail.com](santiago.torales@gmail.com)), Darío García and Emanuel Medina  \nIntroduction: Access to gender reassignment surgery (GRS) as an isolated process would not imply achieving clinical and satisfaction results in transgender people. Public subsystems face a shortage of trained professionals, a lack of protocols, fragmented care, and economic and geographic barriers. This review sought evidence on integrated and equitable care models for access to GRS.  \nMethods: A systematic review(SR)was conducted on the effectiveness and safety of GRS prevalent in Argentina (vulvovaginoplasty [VVP] and mastectomy [MRP]) in transgender people older than 16 years. The SR also considered final perceptions from an integrated and comprehensive management approach. The Web of Science and MEDLINE databases were consulted, prioritizing clinical trials, SRs, health technology assessments, and relevant individual studies from 1988 to 2024, using a rapid umbrella review methodology. The results of the evidence were ordered by relevant outcomes (aesthetic, satisfaction, complications, mental health)within the framework ofintegrated models applicable to inclusive and equitable health policies.  \nResults: For MRP, six SRs (two specific, four general) and six cohort studies (three specific, three general) were included. For VVP, 16 SRs (nine specific, seven general) and 38 cohort studies (35 specific, three general) were included. Techniques for each surgery were described, citing results about complications (71%), quality of life (48%), mental health (16%), aesthetic aspects (58%), and satisfaction (73%), but only 0.2 percent considered them within frameworks of integrated models. With a lack of quality evidence, challenges persist in unifying classifications of outcomes over time and generalizing findings to different health systems.  \nConclusions: The recommendations of scientific societies and current legal frameworks suggest access to","cbCaicK1ZJo42TGC","https://ap.wps.com/l/cbCaicK1ZJo42TGC","pdf",41082,"English","# Poster Presentations (online)\n## PD41 Potential Life Lost And Indirect Costs Of Ovarian Cancer For Patients In Brazil: A RealWorld Study\n## PD42 Systematic Review Of The Comprehensive Approach To Gender Reassignment Surgery\n## PD43 Efficacy And Safety Of Therapeutic Strategies For Human Brucellosis: A Systematic Review And Network MetaAnalysis","[{\"question\":\"What is the objective of the ovarian cancer study in Brazil?\",\"answer\":\"To describe the patient profile with ovarian cancer and estimate the indirect costs within the Brazilian Unified Health System (SUS).\"},{\"question\":\"How was indirect cost estimated for ovarian cancer patients?\",\"answer\":\"Years of potential life lost (YPLL) were calculated using a Brazilian life expectancy of 79 years, with a productivity threshold of 62 years, and productivity loss costs were converted using GDP per capita values.\"},{\"question\":\"What approach was used to evaluate evidence for gender reassignment surgery?\",\"answer\":\"A rapid umbrella review methodology using Web of Science and MEDLINE, prioritizing clinical trials and systematic reviews, to assess outcomes within integrated care models.\"}]","Efficacy And Safety Of Therapeutic Strategies For Human Brucellosis: A Systematic Review And Network MetaAnalysis | PDF",1790712672]