[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-437540-en":59,"doc-seo-437540-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":72,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80,"preview_page_count":4},437540,137455077381,"Elsa","https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Efficacy and safety of a modified sound therapy for patients with subjective tinnitus (MOST) - a multicentre, double-blind, randomised controlled trial","Tinnitus is a common, often debilitating auditory condition with limited effective treatments. Sound therapy is widely used, yet strong evidence from long-term randomised trials is limited. This multicentre, double-blind, randomised controlled trial evaluated 9-month efficacy and 3-month durability of four daily sound therapies for adults with chronic subjective tinnitus, using Tinnitus Handicap Inventory (THI) outcomes and predefined endpoints to assess complete remission or THI change.","Articles  \nEfficacy and safety of a modified sound therapy for patients with subjective tinnitus (MOST): a multicentre, double-blind, randomised controlled trial  \nDongmei Tang,a,f Dantong Gu,a,f Jiamin Gong,a,f Guangyu Liu,b Lei Zhou,c Aqiang Dai,a Yan Huo,b Pengfei Guan,a Jianning Zhang,b,∗∗∗∗ Xinsheng Huang,c,∗∗∗∗∗ Yunfeng Wang,a,∗∗∗ Shan Sun,a,∗∗ and Huawei Lia,d,e,∗  \naENT Institute and Department of ENT Institute and Otorhinolaryngology, Tinnitus Hyperacusis Center, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai, 200032, China bDepartment of Otolaryngology, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, 110 Ganhe Rd, Shanghai, China  \ncDepartment of Otorhinolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200031, China  \ndInstitutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China  \neThe Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China  \nSummary  \nBackground Tinnitus is a common and often debilitating auditory condition with limited treatment options. While sound therapy is widely used, robust evidence from long-term randomised trials is scarce. We aimed to evaluate the 9-month efficacy and 3-month posttreatment durability of four sound therapies for adults with chronic subjective tinnitus and identify predictors of response.  \nMethods In this multicentre, double-blind, randomised controlled clinical trial, participants (aged 18–80 years) with chronic subjective tinnitus from three academic hospitals in China were included. Participants were randomly 1:1:1:1 assigned to receive one of four daily 2-h interventions: unmodified music (UM), UM plus pitch-centered narrowband noise (UM + NBN), high-frequency–enhanced music (HFEM), or digital frequency-customised relieving sound (DFCRS) . Primary outcome was tinnitus severity assessed by Tinnitus Handicap Inventory (THI) . Assessments occurred at baseline, 1, 2, 3, 6, and 9 months, with a 3-month posttreatment follow-up. Two prespecified primary endpoints were defined: (a) complete remission, operationalised as a THI score of 0 at any follow-up visit within the 9-month period. Participants achieving this endpoint were considered clinically cured, and sound therapy was discontinued; or (b) if complete remission was not achieved by the end of 9 months, the magnitude of improvement was defined as the change in THI score from baseline to the 9-month endpoint. The primary analysis followed the intention-to-treat (ITT) principle, This trial is registered with the Chinese Clinical Trial Registry, ChiCTR2000039007 .  \nFindings Between May 14, 2021, and November 30, 2022, 440 participants (median age 45 years [IQR, 35–56]; 222/ 440 [50⋅5%] male; median tinnitus duration 13 months [IQR, 7–36]) were enrolled and randomly assigned (UM, n = 111; UM + NBN, n = 110; HFEM, n = 108; DFCRS, n = 111) . Baseline characteristics were balanced between the groups. Only one participant in the HFEM group achieved complete remission, with a THI score of 0 at the 6-month follow-up. THI scores significantly decreased over time in all groups (median 50⋅00 [IQR 36⋅00–62⋅00]) at baseline to 9-month follow-up (35⋅00 [24⋅00–48⋅00]; p \u003C 0⋅0001), with effects sustained posttreatment. Significant group × time interactions occurred (UM: F(5, 618) = 11⋅45; UM + NBN: F(5, 605) = 7⋅17; HFEM: F(5, 599) = 8⋅3; DFCRS: F(5, 619) = 12⋅65;  \n*Corresponding author. ENT Institute and Department of ENT Institute and Otorhinolaryngology, Tinnitus Hyperacusis Center, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai, 200032, China.  \n**Corresponding author.  \n***Corresponding author. ENT institute and Otorhinolaryngology","cbCaidnEQ3g0Ute2","https://ap.wps.com/l/cbCaidnEQ3g0Ute2","pdf",1106101,14,"English","en",105,"# Summary\n## Background\n## Methods\n## Findings\n## Interpretation\n## Funding","[{\"question\":\"What was the main goal of the MOST trial?\",\"answer\":\"To evaluate the 9-month efficacy and 3-month posttreatment durability of four sound therapies for adults with chronic subjective tinnitus and to identify predictors of response.\"},{\"question\":\"How were participants assigned to the interventions?\",\"answer\":\"Participants were randomly 1:1:1:1 assigned to one of four 2-hour daily interventions: unmodified music (UM), UM plus pitch-centered narrowband noise (UM + NBN), high-frequency–enhanced music (HFEM), or digital frequency-customised relieving sound (DFCRS).\"},{\"question\":\"What were the primary outcomes and endpoints?\",\"answer\":\"Primary outcome was tinnitus severity measured by the Tinnitus Handicap Inventory (THI). Primary endpoints were complete remission (THI=0 at any follow-up within 9 months) or, if not achieved, the change in THI from baseline to the 9-month endpoint.\"}]","Efficacy and safety of a modified sound therapy for patients with subjective tinnitus (MOST) - a multicentre, double-blind, randomised controlled trial | PDF",1790682289,35,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":140,"head_meta":142,"extra_data":144,"updated_unix":145},"efficacy-and-safety-of-a-modified-sound-therapy-for-patients-with-subjective-tinnitus-most-a-multicentre-double-blind-randomised-controlled-trial","",{"@graph":87,"@context":139},[88,102,122],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,100],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":35,"@type":94,"position":99},"https://docshare.wps.com/document/healthcare/",3,{"item":101,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/efficacy-and-safety-of-a-modified-sound-therapy-for-patients-with-subjective-tinnitus-most-a-multicentre-double-blind-randomised-controlled-trial/437540/",{"url":101,"name":65,"@type":103,"image":104,"author":109,"headline":65,"publisher":111,"fileFormat":114,"inLanguage":74,"description":66,"dateModified":115,"datePublished":116,"encodingFormat":114,"isAccessibleForFree":117,"interactionStatistic":118},"DigitalDocument",{"url":105,"@type":106,"width":107,"height":108},"https://docshare.wps.com/thumbnails/efficacy-and-safety-of-a-modified-sound-therapy-for-patients-with-subjective-tinnitus-most-a-multicentre-double-blind-randomised-controlled-trial/437540.png","ImageObject",300,407,{"name":63,"@type":110},"Person",{"url":92,"name":112,"@type":113},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":119,"interactionType":120,"userInteractionCount":39},"InteractionCounter",{"@type":121},"ViewAction",{"@type":123,"mainEntity":124},"FAQPage",[125,131,135],{"name":126,"@type":127,"acceptedAnswer":128},"What was the main goal of the MOST trial?","Question",{"text":129,"@type":130},"To evaluate the 9-month efficacy and 3-month posttreatment durability of four sound therapies for adults with chronic subjective tinnitus and to identify predictors of response.","Answer",{"name":132,"@type":127,"acceptedAnswer":133},"How were participants assigned to the interventions?",{"text":134,"@type":130},"Participants were randomly 1:1:1:1 assigned to one of four 2-hour daily interventions: unmodified music (UM), UM plus pitch-centered narrowband noise (UM + NBN), high-frequency–enhanced music (HFEM), or digital frequency-customised relieving sound (DFCRS).",{"name":136,"@type":127,"acceptedAnswer":137},"What were the primary outcomes and endpoints?",{"text":138,"@type":130},"Primary outcome was tinnitus severity measured by the Tinnitus Handicap Inventory (THI). Primary endpoints were complete remission (THI=0 at any follow-up within 9 months) or, if not achieved, the change in THI from baseline to the 9-month endpoint.","https://schema.org",{"og:url":101,"og:type":141,"og:title":65,"og:site_name":112,"og:description":66},"article",{"robots":143,"canonical":101},"index,follow",{"doc_id":61,"site_id":75},1791467816]