[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-42984-en":3,"doc-seo-42984-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},42984,3848291630094,"Emma Wilson","https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45",8,"Research & Report","Effects of Polyvinylpyrrolidone on the Crystallization of Amorphous Griseofulvin","Study investigates how polyvinylpyrrolidone (PVP) influences fracture, molecular mobility, and crystallization of amorphous griseofulvin. With 10% (w/w) PVP K90, griseofulvin fracture resistance increases and the average fracture temperature drops by about 6.1 °C versus pure griseofulvin. The statistical linkage between fracture and nucleation weakens. PVP K90 also slows crystal growth kinetics and molecular dynamics, while needle-like crystals form with growth rates comparable to a bubble-induced process, informing mechanisms behind polymer-based amorphous solid dispersion stability.","research papers  \nISSN 1600-5767  \nReceived 27 February 2024  \nAccepted 26 April 2024  \nEdited by F. Meilleur, Oak Ridge National Laboratory, USA, and North Carolina State University, USA  \nKeywords: fracture; crystallization; molecular mobility; surfaces; griseofulvin;  \npolyvinylpyrrolidone; crystal growth.  \nEffects of polyvinylpyrrolidone on the crystallization of amorphous griseofulvin: fracture and molecular mobility  \nYanan Wang,a,b Chai-Yee Chin,b Naveen Kumar Hawala Shivashekaregowdab,c* and Qin Shia*  \naSchool of Pharmacy, Jiangsu Vocational College of Medicine, Yancheng 224005, People’s Republic of China, bSchool of Pharmacy, Faculty of Health and Medical Science, Taylor’s University, Subang Jaya 47500, Malaysia, and cDigital Health and Medical Advancement Impact Laboratory, Taylor’s University, Subang Jaya 47500, Malaysia. *Correspondence  \ne-mail: [navigcp@gmail.com](navigcp@gmail.com), [sqzyf1314@163.com](sqzyf1314@163.com)  \nThis study aims to investigate the fracture, molecular mobility and crystallization behaviors of amorphous griseofulvin (GSF) in the presence of polyvinylpyrrolidone (PVP) . In the presence of 10%(w/w) PVP K90, the fracture resistance of griseofulvin was greatly improved. Compared with the pure GSF system, the average fracture temperature of the griseofulvin–PVP K90 system was decreased to approximately 􀀀 6.1􀀎 C. More importantly, a statistical study revealed that the direct connection between fracture and nucleation of griseofulvin was weakened in the presence of PVP K90 . This study also explored the effects of PVP K90 on the molecular dynamics and crystallization behaviors of amorphous GSF. In the presence of PVP K90, the crystal growth kinetics and molecular dynamics were both slowed down. Interestingly, needle-like crystal growth was observed, exhibiting approximately the same rates as the bubbleinduced process. These findings are important for understanding the complex mechanisms of physical stability of polymer-based amorphous solid dispersions.  \n1. Introduction  \nAs drug discovery becomes more successful, an increasing number of drug candidates and new chemical entities have been found to suffer the problem of poor water solubility (Kalepu & Nekkanti, 2015) . One of the most promising approaches for enhancing the solubility of poorly watersoluble drugs is to use their amorphous form (Taylor & Zhang, 2016; Yu, 2001; Shi, Li et al., 2020; Shi, Wang, Moinuddin et al., 2022) . However, amorphous solids tend to crystallize because of their higher energy, thus losing the advantages in solubility and dissolution (Zhang, Guo et al., 2023) . More importantly, recent studies revealed that crystallization can be much faster at a free surface or interface in comparison with the rates in the interior of amorphous pharmaceutical solids (Shi, Tao et al., 2020; Yu, 2016; Zhang, Xu et al., 2023) .  \nOne of the widely used formulation strategies for maintaining the physical stability of amorphous drugs is to disperse them into a polymer matrix (Zhang, Guo et al., 2023; Shi, Chenet al., 2022; Newman & Zografi, 2021) . Polymers have been widely reported to affect the nucleation, crystal growth and phase separation of amorphous drugs (Zhang, Guo et al., 2023; Shi, Chen et al., 2022; Sun et al., 2012) . The physical stability of polymer-based amorphous pharmaceutical solids can be determined by the physical and chemical properties of the polymer. Ongoing investigations have proposed various mechanisms by which polymers affect the crystallization of amorphous drugs (Cai et al., 2011; Powell et al., 2013; Kestur &  \nresearch papers  \n\n| Taylor, 2013; Mistry & Suryanarayanan, 2016) . Molecular interactions between drug and polymer are also found to be an important factor for maintaining the physical stability of amorphous solids (Kestur & Taylor, 2010; Trasi & Taylor, 2012a) . For instance, Taylor and co-workers reported that a decrease in the crystal growth rates of amorphous drugs correlated well with the","cbCaiflIYZJ1giJ5","https://ap.wps.com/l/cbCaiflIYZJ1giJ5","pdf",1956534,2,1,11,"English","en",105,"# Introduction\n## Amorphous drugs and solubility challenges\n## Polymer matrices as a stabilization strategy\n## Polymer mechanisms: interactions and segmental mobility\n## Role of free surfaces and interfaces in faster crystallization","[{\"question\":\"What is the purpose of adding PVP to amorphous griseofulvin in this study?\",\"answer\":\"The study aims to determine how PVP affects fracture behavior, molecular mobility, and crystallization of amorphous griseofulvin.\"},{\"question\":\"How does 10%(w/w) PVP K90 change griseofulvin fracture behavior?\",\"answer\":\"Fracture resistance improves and the average fracture temperature decreases to approximately 6.1 °C lower than the pure griseofulvin system.\"},{\"question\":\"What happens to crystal growth kinetics and molecular dynamics when PVP K90 is present?\",\"answer\":\"Both crystal growth kinetics and molecular dynamics are slowed down, and needle-like crystal growth is observed with rates similar to the bubble-induced process.\"}]",1783375277,28,{"code":4,"msg":31,"data":32},"ok",{"site_id":25,"language":24,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"effects-of-polyvinylpyrrolidone-on-the-crystallization-of-amorphous-griseofulvin","",{"@graph":36,"@context":85},[37,53,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,47,50],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":20},"https://docshare.wps.com/document/","Document",{"item":48,"name":12,"@type":43,"position":49},"https://docshare.wps.com/document/research-report/",3,{"item":51,"name":13,"@type":43,"position":52},"https://docshare.wps.com/document/effects-of-polyvinylpyrrolidone-on-the-crystallization-of-amorphous-griseofulvin/42984/",4,{"url":51,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":24,"description":14,"dateModified":61,"datePublished":62,"encodingFormat":60,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":41,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-11","2026-07-06",true,{"@type":65,"interactionType":66,"userInteractionCount":20},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What is the purpose of adding PVP to amorphous griseofulvin in this study?","Question",{"text":75,"@type":76},"The study aims to determine how PVP affects fracture behavior, molecular mobility, and crystallization of amorphous griseofulvin.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"How does 10%(w/w) PVP K90 change griseofulvin fracture behavior?",{"text":80,"@type":76},"Fracture resistance improves and the average fracture temperature decreases to approximately 6.1 °C lower than the pure griseofulvin system.",{"name":82,"@type":73,"acceptedAnswer":83},"What happens to crystal growth kinetics and molecular dynamics when PVP K90 is present?",{"text":84,"@type":76},"Both crystal growth kinetics and molecular dynamics are slowed down, and needle-like crystal growth is observed with rates similar to the bubble-induced 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