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This systematic review and meta-analysis examined the association between physical therapy modalities, including therapeutic exercise, manual therapy, and physical agent modality, and HRQOL improvement in PWH. Searches in PubMed, Embase, MEDLINE, and Scopus (to April 2024) included randomized controlled trials comparing physical therapy with control groups. Eight RCTs (298 male PWH) showed HRQOL improvements favoring physical therapy (SMD=0.92; 95% CI 0.50–1.33; p\u003C.001), with therapeutic exercise producing greater benefits.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/effects-of-physical-therapy-on-health-related-quality-of-life-in-inpatients-with-haemophilia-systematic-review-and-meta-analysis/603992/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/effects-of-physical-therapy-on-health-related-quality-of-life-in-inpatients-with-haemophilia-systematic-review-and-meta-analysis/603992.png","ImageObject",300,407,{"name":92,"@type":93},"Jordan Avery","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-10-15",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of this systematic review and meta-analysis?","Question",{"text":112,"@type":113},"To determine whether physical therapy and specific physical therapy types improve HRQOL in patients with haemophilia, and to explore differences by HRQOL instrument type and joint status.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which physical therapy components were analyzed?",{"text":117,"@type":113},"Therapeutic exercise, manual therapy, and physical agent modality were included when examining their association with HRQOL improvement.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the meta-analysis find about HRQOL improvement?",{"text":121,"@type":113},"Physical therapy showed a significant HRQOL improvement compared with control groups (SMD=0.92; 95% CI 0.50–1.33; p\u003C.001), with therapeutic exercise demonstrating more benefit (SMD=1.02; 95% CI 0.49–1.55; p\u003C.001).",{"name":123,"@type":110,"acceptedAnswer":124},"Were the included studies judged to be high risk of bias?",{"text":125,"@type":113},"Yes. Of the eight RCTs, six were rated as high risk of bias, and the overall evidence certainty was moderate, so cautious interpretation was recommended.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},603992,1792713910,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148},1099523882367,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Received: 6 July 2024 Revised: 13 October 2024 Accepted: 24 October 2024  \nDOI: 10.1111/hae.15120  \nREVIEW ARTICLE  \nEffects of physical therapy on health-related quality of life inpatients with haemophilia: A systematic review and  \nmeta-analysis  \nChien-Min Chen1, 2   Shang-Lin Liu1  Mu-Ching Shie1  \n1 Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Taiwan  \n2School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan  \nCorrespondence  \nChien-Min Chen, Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, No. 8, W. Sec., Jiapu Rd., Puzih City, Chiayi County 613, Taiwan. [Email:](Email: fateman53@yahoo.com.tw)[ fateman53@yahoo.com.tw](Email: fateman53@yahoo.com.tw)  \nAbstract  \nIntroduction: Physical therapy benefits patients with haemophilia (PWH), but its impact on the health-related quality of life (HRQOL) remains unclear.  \nAim: This systematic review and meta-analysis investigated the association of physical therapy, including therapeutic exercise, manual therapy, and physical agent modality, with HRQOL improvement in PWH.  \nMethods: Databases PubMed, Embase, MEDLINE, and Scopus were searched from inception until April 2024. This review included randomised controlled trials (RCTs) that compare the HRQOL between the physical therapy and control groups. Relevant data and outcome values of included study were collected. Cochrane collaboration’stool and the grading of recommendations, assessment, development, and evaluation approach were used for risk of bias (ROB) and evidence-level assessment, individually. Results: The systematic review included eight RCTs that involved 298 male PWH. The meta-analysis for HRQOL improvement revealed a significant difference in favour of physical therapy (standardised mean difference [SMD] = . 92; 95% confidence interval [CI]:.50–1. 33; p \u003C .001). Therapeutic exercise exhibited more benefits in HRQOL improvement than the control groups (SMD = 1.02; 95% CI:.49–1. 55; p \u003C .001). Physical therapy effectively improved HRQOL in PWH with better joint status (SMD = 1. 74; 95% CI:.97–2. 51; p \u003C .001). Of the eight RCTs, six were rated as high ROB. The comparisons revealed a moderate certainty of evidence.  \nConclusions: Physical therapy, especially therapeutic exercise, effectively improved the HRQOL of PWH. Maintaining better joint status and timely physical therapy intervention is crucial for HRQOL improvements in PWH. Cautious interpretation is required due to evidence limitations.  \nKEYWORDS  \nhaemophilia, meta-analysis, physical therapy, quality of life  \n1  INTRODUCTION  \nHaemophilia is a congenital bleeding disorder characterised by the deficiency of clotting factorVIII or IX. Patients with haemophilia(PWH) tend to have recurrent haemarthrosis, resulting in iron deposition  \nin the synovial membrane, causing inflammation reaction and then cartilage damage.1 Cartilage damage may cause joint deterioration, resulting in haemophilic arthropathy.  \nQuality of life (QOL) is defined as ‘an overall general well-being that comprises objective descriptors and subjective evaluations of physical,  \n16  \n© 2024 John Wiley & Sons Ltd.  \nwi[leyonlinelibrary.com/journal/hae](leyonlinelibrary.com/journal/hae)  \nHaemophilia. 2025;31:16–25.  \nCHEN ET AL.  \nmaterial, social, and emotional well-being.’2 Health-related QOL (HRQOL) is defined as ‘those aspects of self-perceived well-being that are related to or affected by the presence of disease or treatment.’2 Various HRQOL measurements, either generic instruments, such as 36-item Short-Form Health Survey (SF-36)3 and EQ-5D,4 or disease-specific instruments, including Hemo-A-QoL5 and A-36 Hemofilia-QoL,6 have been validated3–6 and utilised for evaluating the HRQOL of PWH. A study revealed that disease severity, joint bleeding frequency, and therapy affected HRQOL in PWH.7 The physical sequelae of haemophilic arthropathy, for example, greater pain8 and more limitatio","cbCaimAjiG4BlF8K","https://ap.wps.com/l/cbCaimAjiG4BlF8K","pdf",1491837,"English","# Introduction\n## Background on haemophilia and HRQOL\n## Rationale for updating evidence\n# Methods\n## Registration and guidelines\n## Literature search strategy\n## Risk of bias and evidence-level assessment\n# Results\n## Included trials and participant profile\n## Overall HRQOL effects\n## Effects by therapy type and joint status\n# Conclusions","[{\"question\":\"What was the main objective of this systematic review and meta-analysis?\",\"answer\":\"To determine whether physical therapy and specific physical therapy types improve HRQOL in patients with haemophilia, and to explore differences by HRQOL instrument type and joint status.\"},{\"question\":\"Which physical therapy components were analyzed?\",\"answer\":\"Therapeutic exercise, manual therapy, and physical agent modality were included when examining their association with HRQOL improvement.\"},{\"question\":\"What did the meta-analysis find about HRQOL improvement?\",\"answer\":\"Physical therapy showed a significant HRQOL improvement compared with control groups (SMD=0.92; 95% CI 0.50–1.33; p\\u003c.001), with therapeutic exercise demonstrating more benefit (SMD=1.02; 95% CI 0.49–1.55; p\\u003c.001).\"},{\"question\":\"Were the included studies judged to be high risk of bias?\",\"answer\":\"Yes. Of the eight RCTs, six were rated as high risk of bias, and the overall evidence certainty was moderate, so cautious interpretation was recommended.\"}]","Effects of physical therapy on health-related quality of life in inpatients with haemophilia - Systematic review and meta-analysis | PDF",1792099859,25]