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This systematic review consolidates evidence on how nutritional interventions affect nutritional status in patients with digestive cancers at risk of malnutrition. Searches in PubMed, MDPI, Web of Science, and ScienceDirect (2009–2025) identified 14,503 records, with 80 studies meeting inclusion criteria. Findings indicate individualized and early interventions support weight and protein preservation, improve treatment tolerance, and may benefit survival, with nutritional therapy reducing complications and improving quality of life.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/effects-of-dietary-interventions-on-nutritional-status-in-patients-with-gastrointestinal-cancers-a-systematic-review/344660/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/effects-of-dietary-interventions-on-nutritional-status-in-patients-with-gastrointestinal-cancers-a-systematic-review/344660.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the review address in patients with gastrointestinal cancers?","Question",{"text":112,"@type":113},"The review focuses on malnutrition risk in digestive cancer patients and its negative effects on body performance, treatment tolerance, and prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the evidence gathered for this systematic review?",{"text":117,"@type":113},"The review used a systematic search in PubMed, MDPI, Web of Science, and ScienceDirect for studies published between 2009 and 2025.",{"name":119,"@type":110,"acceptedAnswer":120},"What overall effects do the nutritional interventions show?",{"text":121,"@type":113},"Evidence suggests individualized and early nutritional interventions help maintain weight and protein status, improve tolerance to oncological treatments, and may positively influence survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},344660,1790180354,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Systematic Review  \nEffects of Dietary Interventions on Nutritional Status in Patients with Gastrointestinal Cancers: A Systematic Review  \nCamelia Maria Caragescu (Lup) 1, Laura Graiela Vicas, 2, *, Angela Mirela Antonescu 3, Nicole Alina Marian 1, Octavia Gligor 3, Mariana Eugenia Mures, an 1,3, Patricia-Andrada Grigore 4 and Eleonora Marian 1,2  \nAcademic Editor: John  \nK. Triantafillidis  \nReceived: 14 December 2025  \nRevised: 15 January 2026  \nAccepted: 19 January 2026  \nPublished: 21 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Doctoral School of Biomedical Sciences, University of Oradea, No. 1 University Street,  \n410087 Oradea, Romania; [caragescucamelia@ymail.com](caragescucamelia@ymail.com) (C.M.C.); [mariannicole@ymail.com](mariannicole@ymail.com) (N.A.M.); [mmuresan@uoradea.ro](mmuresan@uoradea.ro) (M.E.M.); [emarian@uoradea.ro](emarian@uoradea.ro) (E.M.)  \n2 Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, No. 29 Nicolae Jiga Street, 410028 Oradea, Romania  \n3 Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piata 1 Decembrie Street, 410073 Oradea, Romania; [aantonescu@uoradea.ro](aantonescu@uoradea.ro) (A.M.A.);  \n[octavia.gligor@uoradea.ro](octavia.gligor@uoradea.ro) (O.G.)  \n4 “Saint John” Emergency Clinical Hospital, Vitan-Bârzes, ti Street 13, 042122 Bucharest, Romania; [resteapatri@yahoo.com](resteapatri@yahoo.com)  \n* Correspondence: [lvicas@uoradea.ro](lvicas@uoradea.ro)  \nAbstract  \nIntroduction/Object: Gastrointestinal cancers are among the most common types of neoplasms and are often associated with malnutrition, which affects physical performance, treatment tolerance and prognosis. This paper aims to synthesize, through a systematic search, the evidence on the impact of nutritional interventions on nutritional status inpatients with digestive cancers prone to malnutrition. Methods: A systematic search was performed in PubMed, MDPI, Web of Science and ScienceDirect, for articles published between 2009 and 2025 . Overall, 14,503 records were identified, and after screening of titles, abstracts and full-text evaluation, 80 studies (cross-sectional and cohort) were included. Data extraction was performed by a single researcher, using pre-established criteria and a standardized table, and the assessment of study quality was performed qualitatively, taking into account study design, sample size, nutritional assessment methods and clarity of reporting of results. Results: Evidence suggests that individualized and early applied nutritional interventions contribute to maintaining weight and protein status, improve tolerance to oncological treatments and may positively influence patient survival. Conclusions: Nutritional therapy plays a crucial role in preventing complications and supporting the body during oncological treatment, optimizing patients’ quality of life. This review provides a clear synthesis of the current evidence and recognizes methodological limitations related to the qualitative assessment of the included studies.  \nKeywords: malnutrition; digestive cancers; gastric cancer; colorectal cancer; clinical nutrition; nutritional support; oral supplements; enteral nutrition  \n1. Introduction  \nDigestive tract cancers are the most common types of cancer, and their incidence is constantly increasing [1] . Patients diagnosed with cancer are at increased risk of malnutrition, firstly due to the location of the tumor and secondly due to the complexity of oncological treatment that includes chemotherapy, radiotherapy and extensive  \nsurgery [2] . Once malnutrition is established, the negative consequences on the entire body are quite serious, negatively influencing the treatment. The result is loss of muscle mass, decreased physical performance, and dim","cbCaijaEBbAYcWRy","https://ap.wps.com/l/cbCaijaEBbAYcWRy","pdf",856818,28,"English","# Abstract\n## Introduction/Object\n## Methods\n## Results\n## Conclusions\n# Keywords\n# 1. Introduction","[{\"question\":\"What problem does the review address in patients with gastrointestinal cancers?\",\"answer\":\"The review focuses on malnutrition risk in digestive cancer patients and its negative effects on body performance, treatment tolerance, and prognosis.\"},{\"question\":\"How was the evidence gathered for this systematic review?\",\"answer\":\"The review used a systematic search in PubMed, MDPI, Web of Science, and ScienceDirect for studies published between 2009 and 2025.\"},{\"question\":\"What overall effects do the nutritional interventions show?\",\"answer\":\"Evidence suggests individualized and early nutritional interventions help maintain weight and protein status, improve tolerance to oncological treatments, and may positively influence survival.\"}]","Effects of Dietary Interventions on Nutritional Status in Patients with Gastrointestinal Cancers - A Systematic Review | PDF",1790054783,71]