[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-427585-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-427585-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","effects-of-curcumin-and-sulforaphane-on-c-elegans-healthspan-independent-and-combined-impacts-abstract","EFFECTS OF CURCUMIN AND SULFORAPHANE ON C. ELEGANS HEALTHSPAN: INDEPENDENT AND COMBINED IMPACTS - Abstract","","Aging involves a progressive decline in bodily functions, emphasizing the need for interventions that extend healthspan, the period lived in good health. This study evaluated nine natural products in Caenorhabditis elegans, focusing on curcumin and sulforaphane, using high-throughput automated phenotyping (WormGazer™) and movement-based metrics across adulthood days 2–7. Curcumin improved the fraction of moving worms but showed limited speed effects, while sulforaphane enhanced speed and distance moved in late adulthood. The combination produced similar outcomes to sulforaphane alone, with no additive mobility benefits. Transcriptomic and AI-based molecular analyses identified distinct gene expression profiles, targets, and pathways. Results suggest complementary yet non-synergistic modulation of healthspan by these compounds and support their mechanistic potential for healthy aging.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/effects-of-curcumin-and-sulforaphane-on-c-elegans-healthspan-independent-and-combined-impacts-abstract/427585/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/effects-of-curcumin-and-sulforaphane-on-c-elegans-healthspan-independent-and-combined-impacts-abstract/427585.png","ImageObject",300,407,{"name":42,"@type":43},"Margaret","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":33},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What was the main goal of the study?","Question",{"text":62,"@type":63},"To assess whether curcumin and sulforaphane individually and together enhance healthspan in Caenorhabditis elegans, and to clarify the underlying molecular mechanisms.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were healthspan effects measured in the experiments?",{"text":67,"@type":63},"Using high-throughput automated phenotyping (WormGazer™) to quantify movement-based metrics including the fraction of moving worms, mean speed, and distance moved from days 2 to 7 of adulthood.",{"name":69,"@type":60,"acceptedAnswer":70},"Did combining curcumin and sulforaphane provide additive benefits?",{"text":71,"@type":63},"No. The combination showed effects similar to sulforaphane alone, with no additive benefits across the mobility metrics.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},427585,1790718534,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":33,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30},137451207643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Innovation in Aging, 2025, Vol. 9, No. S2 747  \nAbstract citation ID: igaf122.2541  \nEFFECTS OF CURCUMIN AND SULFORAPHANE ON C. ELEGANS HEALTHSPAN: INDEPENDENT AND  \nCOMBINED IMPACTS  \nR.P. Vivek-Ananth1, Stephen Phipps2, David Weinkove3, and Nathan Price4, 1. Buck Institute for Research on Aging, Novato, California, United States, 2. Thorne HealthTech Inc., New York, New York, United States, 3. Durham University, Durham, England, United Kingdom, 4. The Buck Institute, Navato, California, United States  \nAging involves a progressive decline in bodily functions, underscoring the need for interventions that enhance healthspan—the period of life spent in good health. Natural products like curcumin and sulforaphane show promise in modulating aging-related pathways; however, their combined effects remain largely unexplored. This study evaluated the healthspan-enhancing potential of nine natural products in Caenorhabditis elegans, focusing on the individual and combined effects of curcumin and sulforaphane. Using high-throughput automated phenotyping with WormGazer™, we measured movement-based healthspan metrics—the fraction of moving worms, mean speed, and distance moved—from days 2 to 7 of adulthood. Toxicological evaluations confirmed that all compounds were non-toxic at the selected concentrations. Curcumin increased the fraction of moving worms in early and late adulthood, although its positive effect on speed was limited. In contrast, sulforaphane enhanced speed and distance moved in late adulthood but had variable effects on early mobility. Notably, the combination of curcumin and sulforaphane produced effects similar to those of sulforaphane alone, with no additive benefits observed across mobility metrics. Transcriptomic analyses revealed distinct gene expression profiles for each treatment. Further AI-based analysis identified divergent molecular targetsand pathways, explaining the differing effects of the compounds. These findings highlight the complementary roles of curcumin and sulforaphane in improving healthspan metrics in C. elegans. While both compounds independently enhance aspects of mobility, their lack of synergy underscores the complexity of multi-target interventions in aging biology. This study offers new insights into the molecular mechanisms modulated by natural products and supports their potential in promoting healthy aging.","cbCaiu1R2ucY6VKZ","https://ap.wps.com/l/cbCaiu1R2ucY6VKZ","pdf",676285,"English","# Abstract\n## Study purpose and rationale\n## Methods and measured healthspan metrics\n## Independent effects of curcumin and sulforaphane\n## Combined effects and lack of synergy\n## Transcriptomic and AI-based mechanism analysis\n## Conclusions and implications","[{\"question\":\"What was the main goal of the study?\",\"answer\":\"To assess whether curcumin and sulforaphane individually and together enhance healthspan in Caenorhabditis elegans, and to clarify the underlying molecular mechanisms.\"},{\"question\":\"How were healthspan effects measured in the experiments?\",\"answer\":\"Using high-throughput automated phenotyping (WormGazer™) to quantify movement-based metrics including the fraction of moving worms, mean speed, and distance moved from days 2 to 7 of adulthood.\"},{\"question\":\"Did combining curcumin and sulforaphane provide additive benefits?\",\"answer\":\"No. The combination showed effects similar to sulforaphane alone, with no additive benefits across the mobility metrics.\"}]","EFFECTS OF CURCUMIN AND SULFORAPHANE ON C. ELEGANS HEALTHSPAN: INDEPENDENT AND COMBINED IMPACTS - Abstract | PDF",1790644279]