[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-444065-en":59,"doc-seo-444065-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":72,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80},444065,962085570644,"Melati","https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Effect on Bone Mineralization of Continued Growth Hormone Therapy at the Transition Between Childhood and Adulthood - Research Article","Childhood-onset growth-hormone deficiency (GHD) requires growth-hormone therapy (GHT) to optimize final height, but potential benefits may persist after attainment, particularly for bone. This retrospective single-center observational cohort assessed bone parameters in patients with persistent GHD during transition to adult care and again over 6 months later (~6.08 years). Lumbar spine and hip bone mineral density and Z-scores were compared between those receiving GHT longer than 6 months and those without or with shorter treatment. Results indicated higher lumbar-spine BMD in the GHT group and improved Z-score changes; other sites were not significantly different.","RESEARCH  \nEndocrine Connections (2026) 15 e250346  \n[https://doi.org/10.1530/EC-25-0346](https://doi.org/10.1530/EC-25-0346)  \nReceived 18 June 2025  \nAccepted 10 December 2025 Available online 11 December 2025  \nVersion of Record published 5 January 2026  \n\n| Effect on bone mineralization of continued growth hormone therapy at the transition between childhood and adulthood\u003Cbr>C Bailly􀀁1,2, E Le Roux3, M Polak2,4,5 and P Touraine􀀁1,2,6,*\u003Cbr>1Endocrinology and Reproductive Medicine Department, Piti-Salptrière University Hospital, AP-HP, Paris, France\u003Cbr>2Center for Rare Disorders CRESCENDO, Paris, France\u003Cbr>3Unit of Clinical Epidemiology, Hpital Universitaire Robert-Debr, Assistance Publique des Hpitaux de Paris (AP-HP), Paris, France\u003Cbr>4Pediatric Endocrinology, Diabetology, and Gynecology Department, Necker-Enfants Malades University Hospital, AP-HP, Paris, France\u003Cbr>5Universit Paris Cit, Paris, France\u003Cbr>6Sorbonne University, Paris, France\u003Cbr>Correspondence should be addressed to C Bailly: [clement.bailly@aphp.fr](clement.bailly@aphp.fr)\u003Cbr>*P Touraine is a Senior Editor of Endocrine Connections, and was not involved in the review or editorial process for this paper |\n| --- |\n| Abstract\u003Cbr>Childhood-onset growth-hormone deficiency (GHD) requires growth-hormone therapy (GHT) to optimize final height. GHT may also have benefits after final height is achieved, notably on bone. The objective of this retrospective singlecenter observational cohort study of patients who had persistent GHD after achieving their final height was to assess bone parameters at the transition to adult care and then more than 6 months later (6.08 (3.33–10.25) years) . Bone mineral density (BMD) and Z-score at the lumbar spine and hip were determined. Of 162 patients transitioned to adult care in 1994–2021, 105 received GHT for longer than 6 months (GHT group) and 57 received either no GHT or GHT for less than 6 months (no-GHT group); however, BMD and Z-score data from both evaluations were available for only a minority of patients. Lumbar-spine BMD was significantly higher at the second evaluation in the GHT group than in the no-GHT group (P = 0.034). The lumbar-spine Z-scores at the first and second evaluations were 􀀁1.61 and 􀀁1.32 in the noGHT group vs 􀀁1.09 and 􀀁0.61 in the GHT group (P = 0.047 for the difference in median change over time between groups) . Changes in BMD at the lumbar spine and in BMD and Z-score atthe femoral neck were not significantly different between the two groups. These results suggest beneficial effects of continued GHT in patients with persistent GHD after final height attainment, adding evidence to continue GH therapy during and after the transition period.\u003Cbr>Plain language summary\u003Cbr>Children with insufficient growth-hormone levels are given growth-hormone injections to allow them to gain height. Once the final height is achieved, the treatment is often stopped. However, further treatment during the transition to adulthood may have benefits, notably on bone.\u003Cbr>Keywords: growth hormone deficiency; growth hormone therapy; bone density; transition between childhood and adulthood |\n\nPublished by Bioscientifica Ltd.  \n[https://ec.bioscienti](https://ec.bioscienti)fi[ca.com](ca.com)  \n© 2026 the author(s)  \nThis work is licensed under a Creative Commons Attribution 4 .0 International License.  \nC Bailly et al. Endocrine Connections (2026) 15 e250346  \n[https://doi.org/10.1530/EC-25-0346](https://doi.org/10.1530/EC-25-0346)  \nIntroduction  \nGrowth hormone deficiency (GHD) is a rare disease with a prevalence of 1/1,107 to 1/8,646 (1) . Onset may occur during childhood or adulthood. The diagnosis is challenging for clinicians and for patients and their families. In childhood-onset GHD (CoGHD), replacement growth hormone therapy (GHT) is essential to achieve the optimal final height. CoGHD may persist into adulthood.  \nGHT is a costly intervention whose continuation into adulthood remains controversial due to a scarcity of long-term data (2) . Unt","cbCait8ujikirlBp","https://ap.wps.com/l/cbCait8ujikirlBp","pdf",555031,3,"English","en",105,"# Abstract\n## Plain language summary\n# Introduction\n## Background on GHD and treatment goals\n## Controversy and need for long-term data","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To assess bone parameters in patients who had persistent childhood-onset GHD at the transition to adult care and again more than 6 months later.\"},{\"question\":\"How were patients grouped for comparison?\",\"answer\":\"Among patients transitioned to adult care (1994–2021), 105 received GHT for longer than 6 months, while 57 received no GHT or received it for less than 6 months.\"},{\"question\":\"What bone outcomes differed significantly between groups?\",\"answer\":\"Lumbar-spine bone mineral density was significantly higher at the second evaluation in the GHT group versus the no-GHT group, and lumbar-spine Z-score changes also differed significantly between groups.\"}]","Effect on Bone Mineralization of Continued Growth Hormone Therapy at the Transition Between Childhood and Adulthood - Research Article | PDF",1790706746,18,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":144},"effect-on-bone-mineralization-of-continued-growth-hormone-therapy-at-the-transition-between-childhood-and-adulthood-research-article","",{"@graph":87,"@context":138},[88,101,121],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,99],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":40,"@type":94,"position":72},"https://docshare.wps.com/document/research-report/",{"item":100,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/effect-on-bone-mineralization-of-continued-growth-hormone-therapy-at-the-transition-between-childhood-and-adulthood-research-article/444065/",{"url":100,"name":65,"@type":102,"image":103,"author":108,"headline":65,"publisher":110,"fileFormat":113,"inLanguage":74,"description":66,"dateModified":114,"datePublished":115,"encodingFormat":113,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":104,"@type":105,"width":106,"height":107},"https://docshare.wps.com/thumbnails/effect-on-bone-mineralization-of-continued-growth-hormone-therapy-at-the-transition-between-childhood-and-adulthood-research-article/444065.png","ImageObject",300,407,{"name":63,"@type":109},"Person",{"url":92,"name":111,"@type":112},"DocShare","Organization","application/pdf","2026-10-04","2026-09-29",true,{"@type":118,"interactionType":119,"userInteractionCount":72},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"What was the study’s main objective?","Question",{"text":128,"@type":129},"To assess bone parameters in patients who had persistent childhood-onset GHD at the transition to adult care and again more than 6 months later.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"How were patients grouped for comparison?",{"text":133,"@type":129},"Among patients transitioned to adult care (1994–2021), 105 received GHT for longer than 6 months, while 57 received no GHT or received it for less than 6 months.",{"name":135,"@type":126,"acceptedAnswer":136},"What bone outcomes differed significantly between groups?",{"text":137,"@type":129},"Lumbar-spine bone mineral density was significantly higher at the second evaluation in the GHT group versus the no-GHT group, and lumbar-spine Z-score changes also differed significantly between groups.","https://schema.org",{"og:url":100,"og:type":140,"og:title":65,"og:site_name":111,"og:description":66},"article",{"robots":142,"canonical":100},"index,follow",{"doc_id":61,"site_id":75},1791081623]