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Consecutive participants with climacteric symptoms were allocated to tibolone (2.5 mg) or HRT using estradiol valerate (1 mg) plus medroxyprogesterone acetate (2.5 mg). Tibolone showed greater improvement in dizziness/faintness, while anxiety, depression, somatic and vasomotor symptoms, and sexual function improved similarly in both groups. Psychological distress improved after both treatments, with neuroticism improving with tibolone.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/effect-of-tibolone-vs-hormone-replacement-therapy-on-climacteric-symptoms-and-psychological-distress/436102/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/effect-of-tibolone-vs-hormone-replacement-therapy-on-climacteric-symptoms-and-psychological-distress/436102.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the primary objective of the study?","Question",{"text":112,"@type":113},"To compare the effect of tibolone versus HRT on climacteric symptoms and psychological distress.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants assigned to treatment groups?",{"text":117,"@type":113},"Women with climacteric symptoms were allocated to receive tibolone (2.5 mg) or estradiol valerate (1 mg) plus medroxyprogesterone acetate (2.5 mg) based on allocation criteria described in the study.",{"name":119,"@type":110,"acceptedAnswer":120},"Which symptom showed a more prominent improvement with tibolone?",{"text":121,"@type":113},"The improvement in “feeling dizzy or faint” was more prominent after tibolone than after HRT.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436102,1790847564,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","J Chin MedAssoc  \nOriginal article  \nEffect of tibolone vs hormone replacement therapy on climacteric symptoms and psychological distress  \nSheng-Mou Hsiaoa,b,c,* , Shih-Cheng Liaod  \naDepartment of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC; bGraduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan, ROC; cDepartment of Obstetrics and Gynecology, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC; dDepartment of Psychiatry, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC  \nAbstract  \nBackground: The objective was to elucidate the effect of tibolone vs hormone replacement therapy (HRT) on climacteric symptoms and psychological distress.  \nMethods: All consecutive women with climacteric symptoms were allocated to receive tibolone (2 .5 mg) or estradiol valerate (1 mg) plus medroxyprogesterone acetate (2 .5 mg) .  \nResults: The improvement in “feeling dizzy or faint” after tibolone treatment was more prominent than that after HRT (−0 .7 ± 0.8 vs −0.0 ± 0.9, p = 0 .004) . In addition, other climacteric symptoms, including anxiety, depression, somatic symptoms, and vasomotor symptoms, and sexual function improved after tibolone and HRT, but there were no between-group differences. Psychological distress assessment demonstrated that somatic complaints, obsessive-compulsive symptoms, depressive symptoms, hostility, additional symptoms, and the General Symptom Index improved after tibolone treatment and HRT, but there were no betweengroup differences. Personality traits assessment revealed that neuroticism improved after tibolone treatment.  \nConclusion: Tibolone seems more beneficial than HRT in treating symptoms of dizziness and faintness. Both tibolone and HRT could improve psychological distress.  \nKeywords: Menopause; Personality; Psychological distress  \n1. INTRODUCTION  \nPsychological distress, such as anxiety and depression, is common in women with climacteric symptoms.1–3 Hormone replacement therapy (HRT) or tibolone is frequently prescribed for women with climacteric symptoms.4–6 HRT was reported to have a beneficial effect on psychological distress in addition toclimacteric symptoms.7–9 In addition, HRT could facilitate the efficacy of antidepressants.10 Nonetheless, Stephens and Ross11 reported that there was no relationship between HRT use and psychological symptoms.  \nTibolone is converted to three active metabolites after oral ingestion, and two metabolites have estrogenic effects on the bones, vagina, and climacteric symptoms.12 Thus, tibolone has a therapeutic effect on climacteric symptoms. In addition, tibolone seems to have a beneficial effect on mood due to an increased plasma beta-endorphin levels.13,14 Egarter et al9 found  \n* Address correspondence. Dr. Sheng-Mou Hsiao, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, 21, Section 2, Nanya South Road, Banqiao District, New Taipei City, Taiwan, ROC. E-mail address: smhsiao2@gmail. com (S.-M. Hsiao).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2024) 87: 189-195.  \nReceived April 30, 2023; accepted August 26, 2023. doi: 10. 1097/JCMA.0000000000001012  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nthat tibolone had a greater effect on depression and mood disorders than HRT.  \nUnderstanding the between-group differences in the effects onclimacteric symptoms and psychological distress should be helpful in choosing a suitable medication for climacteric symptoms. Thus, the primary objective of this","cbCaicTG9Eqflm99","https://ap.wps.com/l/cbCaicTG9Eqflm99","pdf",613678,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods","[{\"question\":\"What is the primary objective of the study?\",\"answer\":\"To compare the effect of tibolone versus HRT on climacteric symptoms and psychological distress.\"},{\"question\":\"How were participants assigned to treatment groups?\",\"answer\":\"Women with climacteric symptoms were allocated to receive tibolone (2.5 mg) or estradiol valerate (1 mg) plus medroxyprogesterone acetate (2.5 mg) based on allocation criteria described in the study.\"},{\"question\":\"Which symptom showed a more prominent improvement with tibolone?\",\"answer\":\"The improvement in “feeling dizzy or faint” was more prominent after tibolone than after HRT.\"}]","Effect of tibolone vs hormone replacement therapy on climacteric symptoms and psychological distress | PDF",1790676788,18]