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Certain Se (+4) compounds such as Selol show anticancer activity via pro-oxidative effects that can damage cells and promote cell death, making them candidates for therapy. This study evaluated Selol’s impact on tumor morphology and the oxidative–antioxidative balance in blood and tumors in healthy and tumor-bearing mice. Antioxidant enzymes (Se-GPx, GPx, GST, TrxR) were measured spectrophotometrically, along with plasma PSA, plasma/tumor MDA, selenium levels, tumor ORAC, and tumor p53, BCL2, and Ki-67 expression. Results suggest Selol alters tumor cell morphology and may induce necrotic cell death; long-term supplementation increases antioxidant defenses in healthy animals and triggers oxidative stress in cancer cells. 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It is proposed to exert pro-oxidative effects that can lead to cellular damage and cell death, potentially targeting cancer biology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study assess oxidative stress and antioxidant status?",{"text":117,"@type":113},"The research measured antioxidant enzyme activities (Se-GPx, GPx, GST, TrxR) in blood and tumor tissue. It also quantified biomarkers such as MDA, selenium concentrations, and tumor ORAC value to characterize oxidative–antioxidative balance.",{"name":119,"@type":110,"acceptedAnswer":120},"What biological effects of Selol were observed in tumor-bearing mice?",{"text":121,"@type":113},"Selol treatment influenced tumor cell morphology, with results indicating a potential role in inducing cell death through necrosis. It also affected antioxidant defenses in cancer cells and was associated with changes in tumor biomarker expression including p53, BCL2, and Ki-67.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331294,1790122200,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","nutrients   \nArticle  \nEffect of Selol on Tumor Morphology and Biochemical Parameters Associated with Oxidative Stress in a Prostate Tumor-Bearing Mice Model  \nMałgorzata Sochacka 1, *, Grayna Hoser 2, Małgorzata Remiszewska 3, Piotr Suchocki 1, Krzysztof Sikora 4 and Joanna Giebułtowicz 1  \nCitation: Sochacka, M.; Hoser, G.; Remiszewska, M.; Suchocki, P.; Sikora, K.; Giebułtowicz, J. Effect of Selol on Tumor Morphology and Biochemical Parameters Associated with Oxidative Stress in a Prostate Tumor-Bearing Mice Model. Nutrients 2024, 16, 2860 . [https://doi.org/10.3390/nu16172860](https://doi.org/10.3390/nu16172860)  \nAcademic Editor: Giorgio Ivan Russo  \nReceived: 5 July 2024  \nRevised: 17 August 2024  \nAccepted: 19 August 2024  \nPublished: 27 August 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, PL-02097 Warsaw, Poland; [piotr.suchocki@wum.edu.pl](piotr.suchocki@wum.edu.pl) (P.S.); [joanna.giebultowicz@wum.edu.pl](joanna.giebultowicz@wum.edu.pl) (J.G.)  \n2 Department of Translational Immunology and Experimental Intensive Care, Centre of Postgraduate Medical Education, Ceglowska 80, PL-01809 Warsaw, Poland  \n3 Department of Pharmacology, National Medicines Institute, 30/34 Chełmska Street, PL-00725 Warsaw, Poland; [malgorzata.remiszewska@nil.gov.pl](malgorzata.remiszewska@nil.gov.pl)  \n4 Pathomorphology Centre, National Medical Institute of the Ministry of the Interior and Administration, 137 Wołoska Street, PL-02507 Warsaw, Poland  \n* [Correspondence: malgorzata.bogucka@wum.edu.pl](Correspondence: malgorzata.bogucka@wum.edu.pl); Tel.: +48-22-5720630  \nAbstract: Prostate cancer is the leading cause of cancer death in men. Some studies suggest that selenium Se (+4) may help prevent prostate cancer. Certain forms of Se (+4), such as Selol, have shown anticancer activity with demonstrated pro-oxidative effects, which can lead to cellular damage and cell death, making them potential candidates for cancer therapy. Our recent study in healthy mice found that Selol changes the oxidative–antioxidative status in blood and tissue. However, there are no data on the effect of Selol in mice with tumors, considering that the tumor itself influences this balance. This research investigated the impact of Selol on tumor morphology and oxidative–antioxidative status in blood and tumors, which may be crucial for the formulation’s effectiveness. Our study was conducted on healthy and tumor-bearing animal models, which were either administered Selol or not. We determined antioxidant enzyme activities (Se-GPx, GPx, GST, and TrxR) spectrophotometrically in blood and the tumor. Furthermore, we measured plasma prostate-specific antigen (PSA) levels, plasma and tumor malondialdehyde (MDA) concentration as a biomarker of oxidative stress, selenium (Se) concentrations and the tumor ORAC value. Additionally, we assessed the impact of Selol on tumor morphology and the expression of p53, BCL2, and Ki-67 . The results indicate that treatment with Selol influences the morphology of tumor cells, indicating a potential role in inducing cell death through necrosis. Long-term supplementation with Selol increased antioxidant enzyme activity in healthy animals and triggered oxidative stress in cancer cells, activating their antioxidant defense mechanisms. This research pathway shows promise in understanding the anticancer effects of Selol. Selol appears to increase the breakdown of cancer cells more effectively in small tumors than in larger ones. In advanced tumors, it may accelerate tumor growth if used as mon","cbCaintwq6udK0b3","https://ap.wps.com/l/cbCaintwq6udK0b3","pdf",1031288,15,"English","# Introduction\n## Oxidative stress as a therapeutic target in prostate cancer\n## Selenium and mechanistic rationale for Selol","[{\"question\":\"What is Selol, and why is it relevant to prostate cancer treatment?\",\"answer\":\"Selol is a selenium (+4) compound studied for anticancer activity. It is proposed to exert pro-oxidative effects that can lead to cellular damage and cell death, potentially targeting cancer biology.\"},{\"question\":\"How did the study assess oxidative stress and antioxidant status?\",\"answer\":\"The research measured antioxidant enzyme activities (Se-GPx, GPx, GST, TrxR) in blood and tumor tissue. It also quantified biomarkers such as MDA, selenium concentrations, and tumor ORAC value to characterize oxidative–antioxidative balance.\"},{\"question\":\"What biological effects of Selol were observed in tumor-bearing mice?\",\"answer\":\"Selol treatment influenced tumor cell morphology, with results indicating a potential role in inducing cell death through necrosis. It also affected antioxidant defenses in cancer cells and was associated with changes in tumor biomarker expression including p53, BCL2, and Ki-67.\"}]","Effect of Selol on Tumor Morphology and Biochemical Parameters Associated with Oxidative Stress in a Prostate Tumor-Bearing Mice Model | PDF",1789992561,38]