[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31379":3,"doc-seo-31379":26},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":11,"language":20,"language_code":21,"table_of_contents":22,"faqs":23,"seo_title":13,"seo_description":14,"update_tm":24,"read_time":25},31379,8796095462418,"Noah","https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780",8,"Research & Report","Effect of Photobiomodulation Therapy on TGF β Release from Dentin","Dental pulp vitality is essential for long-term tooth function, yet irreversible inflammation or necrosis from infection or trauma often makes root canal treatment necessary, despite limitations such as brittleness, fracture risk, and impaired dentin formation in young teeth. Regenerative endodontics seeks to replace diseased pulp with regenerated tissue using disinfection, revascularization, stem cells, and ECM cues. Photobiomodulation (PBM) is evaluated as an adjunct to support pulp regeneration by influencing cell proliferation, differentiation, and TGF-β release from dentin, while addressing DPSC migration and viability.","cbCaipAUn9RyjAWK","https://ap.wps.com/l/cbCaipAUn9RyjAWK","pdf",3117772,1,"English","en","# Introduction\n## Regenerative endodontics and PBM therapy\n## Role of TGF-β signaling and DPSC behavior\n## Dentin matrix growth factors and EDTA considerations\n# Methods and Materials\n## Experimental design and ethics approval\n## Preparation of dentin discs","[{\"question\":\"Why is maintaining dental pulp vitality important?\",\"answer\":\"Dental pulp nourishes the tooth and provides defense against pathogens. When it becomes irreversibly inflamed or necrotic, root canal treatment is required, which can still lead to complications and reduced regenerative capacity.\"},{\"question\":\"What role does PBM therapy play in regenerative endodontics?\",\"answer\":\"PBM therapy can stimulate cellular processes involved in tissue repair, including proliferation, differentiation, ATP production, mitochondrial respiration, and bone formation. It is considered a potential adjunct that may enhance dental pulp regeneration.\"},{\"question\":\"How is TGF-β linked to stem cell differentiation in this context?\",\"answer\":\"The TGF-β signaling pathway is described as crucial for regulating dental pulp stem cell differentiation. TGF-β1 influences Oct4 and Nanog pathways, which help maintain an undifferentiated state; modulating TGF-β signaling can guide differentiation toward odontogenic lineages.\"}]",1779397298,20,{"code":4,"msg":27,"data":28},"ok",{"site_id":29,"language":21,"slug":30,"title":13,"keywords":31,"description":14,"schema_data":32,"social_meta":83,"head_meta":85,"extra_data":87,"updated_unix":24},105,"effect-of-photobiomodulation-therapy-on-tgf-release-from-dentin","",{"@graph":33,"@context":82},[34,51,65],{"@type":35,"itemListElement":36},"BreadcrumbList",[37,41,45,48],{"item":38,"name":39,"@type":40,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":42,"name":43,"@type":40,"position":44},"https://docshare.wps.com/document/","Document",2,{"item":46,"name":12,"@type":40,"position":47},"https://docshare.wps.com/document/research-report/",3,{"item":49,"name":13,"@type":40,"position":50},"https://docshare.wps.com/document/effect-of-photobiomodulation-therapy-on-tgf-release-from-dentin/31379/",4,{"url":49,"name":13,"@type":52,"author":53,"headline":13,"publisher":55,"fileFormat":58,"description":14,"dateModified":59,"datePublished":59,"encodingFormat":58,"isAccessibleForFree":60,"interactionStatistic":61},"DigitalDocument",{"name":9,"@type":54},"Person",{"url":38,"name":56,"@type":57},"DocShare","Organization","application/pdf","2026-05-21",true,{"@type":62,"interactionType":63,"userInteractionCount":4},"InteractionCounter",{"@type":64},"ViewAction",{"@type":66,"mainEntity":67},"FAQPage",[68,74,78],{"name":69,"@type":70,"acceptedAnswer":71},"Why is maintaining dental pulp vitality important?","Question",{"text":72,"@type":73},"Dental pulp nourishes the tooth and provides defense against pathogens. When it becomes irreversibly inflamed or necrotic, root canal treatment is required, which can still lead to complications and reduced regenerative capacity.","Answer",{"name":75,"@type":70,"acceptedAnswer":76},"What role does PBM therapy play in regenerative endodontics?",{"text":77,"@type":73},"PBM therapy can stimulate cellular processes involved in tissue repair, including proliferation, differentiation, ATP production, mitochondrial respiration, and bone formation. It is considered a potential adjunct that may enhance dental pulp regeneration.",{"name":79,"@type":70,"acceptedAnswer":80},"How is TGF-β linked to stem cell differentiation in this context?",{"text":81,"@type":73},"The TGF-β signaling pathway is described as crucial for regulating dental pulp stem cell differentiation. TGF-β1 influences Oct4 and Nanog pathways, which help maintain an undifferentiated state; modulating TGF-β signaling can guide differentiation toward odontogenic lineages.","https://schema.org",{"og:url":49,"og:type":84,"og:title":13,"og:site_name":56,"og:description":14},"article",{"robots":86,"canonical":49},"index,follow",{"doc_id":7,"site_id":29}]