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Mediterranean diet adherence was inversely associated with DAPSA, HAQ, and ESR, while higher cholesterol, sodium, and BMI related to greater 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10.5152/ArchRheumatol.2025.25030  \nEffect of Nutritional Ingredients on Disease Activation in Psoriatic Arthritis  \nABSTRACT  \nBackground/Aims: To investigate the relationship between food composition and patterns and disease activity in psoriatic arthritis (PsA) patients.  \nMaterials and Methods: This cross-sectional study evaluated patients with PsA (n = 73) . Sociodemographic and disease-related parameters, includingthe duration of illness, Disease Activity Index for PsA (DAPSA), C-reactive protein, erythrocyte sedimentation rate (ESR), the Health Assessment Questionnaire (HAQ), and Mediterranean Diet Compatibility Scale were assessed. Nutrient intake was recorded over 3 days and analyzed using a standard nutritional analysis program. Processed food consumption was classified according to the NOVA system.  \nResults: Among the patients with PsA, 71.2% of patients were female, 42.5% were obese, and 72.6% had low adherence to the Mediterranean diet (MD) . The body mass index (BMI) and HAQ scores were higher in those with moderate-severe disease (DAPSA ≥ 15) than in those in remission or with mild disease (DAPSA ≤ 14) (P = 0.006 and P = 0.008, respectively) . The MD adherence score was negatively correlated with the DAPSA, HAQ, and ESR (P = .025, P = .015, and P = .006, respectively) . Higher adherence to the MD was associated with a lower risk of moderate-to-severe disease, while increases in cholesterol intake, sodium intake, and BMI were associated with a higher risk of disease severity.  \nConclusion: Obesity negatively affects disease progression in PsA. A protein-rich and a low-sodium diet appear to support remission, while poor adherence to the MD and high cholesterol intake may contribute to increased disease activity. These findings emphasize the importance of nutrition in the clinical course of PsA.  \nKeywords: Mediterranean diet, obesity, processed foods, psoriatic arthritis  \nIntroduction  \nPsoriatic arthritis (PsA) is a complex disease characterized by various clinical symptoms affecting both the musculoskeletal system and the skin. Numerous indices have been introduced to evaluate disease activity in recent years, each considering diverse combinations of illness features.1 The Disease Activity Index for PsA (DAPSA) has proven efficacy and reliability for assessing PsA patients’ activity and response to treatment.2  \nObesity contributes to the pathophysiology of rheumatic disorders, including PsA. Studies have shown that obesity negatively affects the course of these diseases.3 Patients with PsA who are obese have lower anti-tumor necrosis factor medication effectiveness.4 ,5 Elevated body mass index (BMI) has a significant impact on both the pathogenesis and prognosis of PsA.3  \nCopyright@Author(s) -[Available online at archivesof rheumatology.com](Available online at archivesof rheumatology.com). Content of this journal is licensed under a Creative Commons Attribution (CC BY) 4.0 International License.  \nGizem Varkal1 Neşeriz Nihal Akarca2 İpek Türk1  \nAyşegül Yetişir3 Burak Mete4  \n1Division of Rheumatology, Department of Internal Medicine,Çukurova University Faculty of Medicine, Adana, Türkiye 2Department of Nutrition and Dietetics, Çukurova University, Adana, Türkiye  \n3Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Çukurova University Faculty of Medicine, Adana, Türkiye  \n4Division of Public Health, Department of Internal Medicine,Çukurova University Faculty of Medicine, Adana, Türkiye  \nCorresponding author: Gizem Varkal  \n􀀍 [dr.gizem.varkal@gmail.com](dr.gizem.varkal@gmail.com)  \nReceived: May 15, 2025  \nRevision Requested: July 07, 2025 Last Revision Received: August 04, 2025  \nAccepted: September 21, 2025  \nPublication Date: December 1, 2025  \nCite this article as: Varkal G, Akarca NN, Türk İ, Yetişir A, Mete B. Effect of nutritional ingredients on disease activation in psoriatic arthritis. Arch Rheumatol. 20","cbCaihTpJGg0a9U8","https://ap.wps.com/l/cbCaihTpJGg0a9U8","pdf",307945,"English","# Abstract\n# Introduction\n# Methods\n## Nutritional assessment and processed food classification\n# Results\n# Conclusion","[{\"question\":\"What was the study’s main objective in PsA patients?\",\"answer\":\"To determine the relationship between food composition and patterns of disease activity in psoriatic arthritis patients.\"},{\"question\":\"How were diet and processed foods measured in the study?\",\"answer\":\"Nutrient intake was recorded over 3 days using a standard nutritional analysis program, and processed food consumption was classified using the NOVA system.\"},{\"question\":\"What dietary factors were linked to higher or lower disease severity?\",\"answer\":\"Higher adherence to the Mediterranean diet was associated with lower risk of moderate-to-severe disease, whereas higher cholesterol intake, sodium intake, and BMI were associated with increased disease severity.\"}]","Effect of Nutritional Ingredients on Disease Activation in Psoriatic Arthritis | PDF",1790576856,15]