[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-433408-105":59,"doc-detail-433408-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","effect-of-dietary-sodium-nitrite-supplementation-on-spontaneous-intracerebral-hemorrhage-in-stroke-prone-spontaneously-hypertensive-rats","Effect of Dietary Sodium Nitrite Supplementation on Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats","","Diet-derived nitrite may improve cardiovascular function, yet its influence on spontaneous intracerebral hemorrhage (ICH) remains unclear. This research examined chronic nitrite supplementation in stroke-prone spontaneously hypertensive/Izumo strain (SHRSP/Izm) rats fed a high-salt diet, evaluating survival and spontaneous ICH outcomes. Across 14 weeks, survival curves were comparable, while nitrite notably lowered ICH incidence and reduced cerebral hemorrhage severity. Blood pressure, cardiac mass, and brain mass were also assessed.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/effect-of-dietary-sodium-nitrite-supplementation-on-spontaneous-intracerebral-hemorrhage-in-stroke-prone-spontaneously-hypertensive-rats/433408/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/effect-of-dietary-sodium-nitrite-supplementation-on-spontaneous-intracerebral-hemorrhage-in-stroke-prone-spontaneously-hypertensive-rats/433408.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-29",true,{"@type":101,"interactionType":102,"userInteractionCount":14},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What was the main purpose of the study on sodium nitrite supplementation?","Question",{"text":111,"@type":112},"To determine how chronic dietary nitrite supplementation affects survival and the risk and severity of spontaneous intracerebral hemorrhage in SHRSP/Izm rats given a high-salt diet.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How were the rats treated in the two experimental groups?",{"text":116,"@type":112},"One group received saline drinking water, while the other received nitrite-added saline drinking water for 14 weeks.",{"name":118,"@type":109,"acceptedAnswer":119},"Did nitrite supplementation change survival rates?",{"text":120,"@type":112},"No. Survival curves during the study period did not differ significantly between the control and nitrite groups.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},433408,1790718552,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":142,"read_time":143},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Prev. Nutr. Food Sci. 2025;30(6):539-548 [https://doi.org/10.3746/pnf.2025.30.6.539](https://doi.org/10.3746/pnf.2025.30.6.539)[ ](https://doi.org/10.3746/pnf.2025.30.6.539)[ISSN 2287-8602](ISSN 2287-8602)  \nEffect of Dietary Sodium Nitrite Supplementation on Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats  \nShang Ran 1,2, Yuka Kono 1,3, Kunihiro Sonoda3, Kazuya Kitamori3, Kazuo Ohtake4, Mari Mori5, Theodore W. Kurtz6, Yukio Yamori7, Jun Kobayashi8, Hinako Nakayama 1, Taketo Fukuoka 1, Yuki Kawai 1, Haruka Tago 1, Nobuhisa Watanabe1, Ikumi Sato9, Shusei Yamamoto9, Satoshi Hirohata9, and  \nShogo Watanabe9  \n1 Department of Medical Laboratory Science, Graduate School of Health Sciences and 9 Department of Medical Laboratory Science, Faculty of Health Sciences, Okayama University, Okayama 700-8558, Japan  \n2 Department of Pathology, Beichen Traditional Chinese Medical Hospital, Tianjin 300400, China  \n3 Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Aichi 463-8521, Japan  \n4 Division of Physiology, School of Pharmaceutical Sciences, Faculty of Pharmaceutical Science and 8 Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Josai University, Saitama 350-0295, Japan  \n5 Department of Health Management, School of Health Studies, Tokai University, Kanagawa 259-1292, Japan  \n6 Department of Laboratory Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA 7Research Institute for Health Science, Mukogawa Women’s University, Hyogo 662-0833, Japan  \nABSTRACT: Diet-derived nitrite can benefit cardiovascular function. However, the effects of nitrite supplementation onidiopathic intracerebral hemorrhage (spontaneous ICH) are unclear. This study, therefore, investigated the impacts of chronic nitrite supplementation on the survival rate and risk for spontaneous ICH in stroke-prone spontaneously hypertensive/Izumo strain (SHRSP/Izm) rats fed with a high-salt diet. Experimental study I-six-week-old male rats were categorized into two groups: (1) SHRSP+salt, in which rats were administered saline drinking water, and (2) SHRSP+salt+ nitrite, in which rats were administered nitrite-added saline drinking water for 14 weeks each. The survival curves during this period did not vary significantly between the groups. However, nitrite administration markedly reduced the incidence ofICH and the extent of cerebral hemorrhage. Experimental study II-the impacts of nitrite supplementation on blood pressure in salt-loaded 8-week-old male SHRSP/Izm rats were evaluated for >4 weeks. During the first week, systolic blood pressure was remarkably lower in the nitrite group than in the control (without nitrite feeding). Similarly, at week 4, cardiac mass and brain mass were significantly lower. In conclusion, nitrite treatment reduced the extent of cerebral hemorrhage caused by hypertension and administration of a high-salt diet.  \nKeywords: cerebral hemorrhage, hypertension, nitric oxide, nitrites  \nINTRODUCTION  \nStroke is classified as ischemic or hemorrhagic. The incidence rate of ischemic stroke has decreased in recent decades, unlike that of hemorrhagic strokes, such as subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), as well as the number of severe hospitalizations among the elderly (Rothwell et al., 2004; Islam et al., 2008; An et al., 2017). Hemorrhagic stroke accounts for 18%－24% of all cases and is more common  \nin men; its risk enhances with age (Ojaghihaghighi et al., 2017). Hemorrhagic strokes, including ICH and SAH, are associated with high mortality rates (Qureshi et al., 2009; Keep et al., 2012) and have a much worse prognosis compared to ischemic stroke, with a 30-day mortality rate of ≤50%(Broderick et al., 1992; Castello et al., 2022). Controlling the growth of a hematoma caused by vascular rupture is an important therapeutic strategy for hemorrhagic st","cbCaibY9feif4dHc","https://ap.wps.com/l/cbCaibY9feif4dHc","pdf",2866200,"English","# Abstract\n# Introduction","[{\"question\":\"What was the main purpose of the study on sodium nitrite supplementation?\",\"answer\":\"To determine how chronic dietary nitrite supplementation affects survival and the risk and severity of spontaneous intracerebral hemorrhage in SHRSP/Izm rats given a high-salt diet.\"},{\"question\":\"How were the rats treated in the two experimental groups?\",\"answer\":\"One group received saline drinking water, while the other received nitrite-added saline drinking water for 14 weeks.\"},{\"question\":\"Did nitrite supplementation change survival rates?\",\"answer\":\"No. Survival curves during the study period did not differ significantly between the control and nitrite groups.\"}]","Effect of Dietary Sodium Nitrite Supplementation on Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats | PDF",1790664010,25]